Mechanisms involved in the anti-tumor effect of introduction of a mutant from of I_KBα gene into human oral cancer cells
| Project/Area Number |
13672102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AZUMA Masayuki Tokushima University School of Dentistry, Assistant Prof, 歯学部附属病院, 講師 (20144983)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | NF-_KB / I_KBα / Head and neck cancers / Apoptosis / Anti-cancer agents / NFкB / lкBα / 血管新生因子 |
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| Research Abstract |
We have demonstrated in this research project as follows:
1. Human head and neck cancer cells express an augmented NF-_KB activity as compared to normal cells.
2. Inhibition of NF-_KB activity by introduction of a mutant form of I_KBα cDNA results in the suppression of tumor growth of head and neck cancer cells via the inhibition of angiogenesis.
3. 5-Fluorouracil induces apoptosis in human salivary gland cancer cells by suppression of NF-_KB via inhibition of I_KB kinase activity.
4. Suppression of TNF-α-induced MMP-9 production in human salivary gland acinar cells by Cepharanthine occurs via down-regulation of NF-_KB.
5. Cisplatin induces apoptosis in oral squamous carcinoma cells by the mitochondria-mediated but not the NF-_KB-suppressed pathway.
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Report
(3 results)
Research Products
(24 results)
