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CHANGES OF HEMODYNAMICS AND CATECHOLAMINE CONCENTRATIONS AFTER THE ADMINISTRATION OF 1/200,000 EPINEPHRINE IN ELDERLY PATIENTS

Research Project

Project/Area Number 13672107
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKagoshima University

Principal Investigator

SUGIYAMA Kazuna  Kagoshima University, Dental Hospital, Professor, 歯学部附属病院, 教授 (50124772)

Co-Investigator(Kenkyū-buntansha) WAKAMATSU Aiko  Kagoshima University, Dental Hospital, Research Associate, 歯学部附属病院, 助手 (50343372)
YOKOYAMA Kozo  Kagoshima University, Dental Hospital, Associate Professor, 歯学部附属病院, 助教授 (80191518)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsElderly patients / Vasoconstrictor / Epinephrine / Norepinephrine / Dopamine / Hemodynamics / Local anesthesia / 血中濃度
Research Abstract

The purpose of the present study was to investigate the changes of hemodynamics and catecholamine concentrations after the administration of 1/200,000 epinephrine contained in local anesthetic solution in elderly patients. Eleven patients scheduled for oral and maxillofacial surgery were divided into two groups; the patients under 64 years old (group 1, N=7) and over 65 years old (group 2, n=4). Anesthesia was induced with the intravenous administration of thiopental or midazolam, and tracheal intubation was facilitated with the administration of vecuronium. After cardiovascular and respiratory conditions were stabilized, 1/200,000 epinephrine contained in 0.5% lidocaine was infiltrated, then the hemodynamic parameters and the serum concentrations of epinephrine, norepinephrine, and dopamine were measured.
In the group 1, systolic, diastolic and mean blood pressure were reduced by 8.1〜10.1%, heart rate increased by 9.0%, cardiac output increased by 16.5%, total peripheral resistance was lowered by 9.1% 80〜90 seconds after the administration of epinephrine contained in lidocaine. The control value of epinephrine concentration in blood was 0.051±0.094 ng/ml, but increased 0.647±0.492 and 0.640±0.213 ng/ml after 120 and 300 seconds, respectively. Norepinephrine and dopamine concentrations did not change significantly.
In the group 2, systolic, diastolic and mean blood pressure were reduced by 7.6〜8.6%, heart rate increased by 6.0%, cardiac output increased by 14.9%, total peripheral resistance was lowered by 17.9% 110〜140 seconds after the administration of epinephrine contained in lidocaine. The control value of epinephrine concentration in blood was 0.018±0.012 ng/ml, but increased 0.094±0.035 and 0.173±0.079 ng/ml after 120 and 300 seconds, respectively. No significant changes in norepinephrine and dopamine concentrations were observed.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

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