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A study on the role of neurotrophines in trigeminal neuropathy and sensory abnormality

Research Project

Project/Area Number 13672113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

IMAMURA Yoshiki  Kyushu Dental College, Dentistry, Associate Professor, 歯学部, 助教授 (90176503)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Eiji  Kyushu Dental College, Dentistry, Instructor, 歯学部, 助手 (00295859)
SHIIBA Shunji  Kyushu Dental College, Dentistry, Instructor, 歯学部, 助手 (20285472)
NAKANISHI Osamu  Kyushu Dental College, Dentistry, Professor, 歯学部, 教授 (50137345)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsNerve injury / Trigeminal Nerve / Neuropathy / NGF / BDNF
Research Abstract

A chronic compression injury to the trigeminal ganglion by an injection of medical silicone via the foramen ovale was induced on seven anesthetized rats (TNP group). The same dissection to the TNP group without injecting silicone was performed on another seven rats (SHM group). Seven rats received cysternal injection of NGF (NGF group) and another seven rats received BDNF (BDNF group). The TNP group and the NGF group showed heat hyperalgesia from fourth post-operative day and mechanical allodynia from seventh post-operative day. However, the SHM and the BDNF groups did not show any significant decrease of thresholds during the time course. These results showed that NGF induces central sensitization by itself and BDNF doesn't have such an effect. In the next study, rats received 200 mg/kg/day or 2000 mg/kg/day of i.p. GSH (NGF-200 group : n-7 and NGF-2000 group : n=7) and 4 mg/kg/day of DEM instead of GSH (NGF-DEM group : n=7) from three days before the NGF injection. Control groups to these groups were prepared by performing sham treatment instead of the NGF injection (SHM-2000 and SHM-DEM groups). NGF-200 and NGF-DEM groups showed decrease of head withdrawal latency from radiant heat stimulation from fourth and seventh post-operative days, respectively. In contrast, NGF-2000, SHM-2000 and SHM-DEM groups did not show any significant behaviors suggesting heat- and mechano-hyperalgesia or allodynia. These results revealed that GSH prevented hyperalgesia by suppressing hypersensitization of the trigeminal nucleus cells that is induced by NGF.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 坂本英治, 椎葉俊司, 今村佳樹, 石川敏三, 鱒見進一, 岩本将嗣, 河原 博, 仲西 修: "ニューロメーターを用いた外傷性三叉神経ニューロパシーの病態評価について"Pain Research. 16(2). 57-62 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 今村佳樹, 坂本英治, 椎葉俊司, 岩本将嗣, 河原 博, 鱒見進一, 仲西 修: "歯科治療後に見られる知覚異常の予後診断に関する研究"Pain Research. 16(2). 83-89 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 椎葉俊司, 坂本英治, 今村佳樹, 岩本将嗣, 河原 博, 仲西 修: "三叉神経領域におけるCurrent Perception Thresholdの臨床に使用に関する研究"慢性疼痛. 20(1). 126-132 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Imamura Y, Shiba S, Sakamoto E, Masumi S, Nakanishi O: "Predicting prognosis of abnormal sensation after trigeminal nerve injury"American Pain Society Bulletin. 12(3). 3-10 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 坂本英治, 椎葉俊司, 今村佳樹, 石川敏三, 鱒見進一, 岩本将嗣, 河原 博, 仲西 修: "外傷性三叉神経ニューロパシーに対する星状神経節ブロックの効果"Pain Research. (印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Imamura, Jeffery P.Okeson: "Chapter 22, Diagnosis of Chronic Orofacial Pain, Management of Pain and Anxiety in the Dental Office, Raymond A. Dionne, James C. Phero and Daniel Becker eds."W. B. Saunders. 418 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Eiji Sakamoto, Shunji Shiiba, Yoshiki Imamura, Toshizo Isshikawa, Shin-ichi Masumi, Masatsugu Iwamoto, Hiroshi Kawahara and Osamu Nakanishi: "Evaluation of nerve damage in traumatic trigeminal neuropathy with Neurometer"Pain Research. 16(2). 57-62 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Imamura, Eiji Sakamoto, Shunji Shiiba, Masatsugu Iwamoto, Hiroshi Kawahara, Shin-ichi Masumi and Osamu Nakanishi: "Prognosis of prolonged abnormal sensation after dental treatment with quantitative sensory testings"Pain Research. 16(2). 83-89 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shunji Shiiba, Eiji Sakamoto, Yoshiki Imamura, Masatsugu Iwamoto, Hiroshi Kawahara and Osamu Nakanishi: "A study of clinical application of Current Perception Threshold in the Traigeminal territory"Chronic Pain. 20(1). 126-132 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Imamura, Shunji Shiiba, Eiji Sakamoto, Shin-ichi Masumi and Osamu Nakanishi: "Predicting prognosis of abnormal sensation after trigeminal nerve injury"American Pain Society Bulletin. 12(3). 3-10 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Eiji Sakamoto, Shunji Shiiba, Yoshiki Imamura, Toshizo Ishikawa, Masagu, Hiroshi Kawahara and Osamu Nakanishi: "Effect of stellate Ganglion Block on Traumatic Trigeminal Neuropathy"Pain Research. 18 : in print.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Imamura and Jeffery P.Okeson, Raymond A.Dionne, James C.Phero and Daniel Becker eds.: "Chapter 22, Diagnosis of Chronic Orofacial Pain, Management of Pain and Anxiety in the Dental Office"W.B.Saunders. 337-353 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y Imamura, S Shiiba, E Sakamoto, S Masaumi, O Nakanishi, GJ Bennett: "Predicting Prognosis of Abnormal SensationsAfter Trigeminal Nerve Injury"Am Pain Soc Bulletin. 13・2. 3-10 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 坂本英治, 椎葉俊司, 今村佳樹, 岩本将嗣, 河原 博, 仲西 修: "痛みに対する不安の影響"総合臨床. 52・9. 2703-2706 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 今村佳樹, 仲西 修: "イラストレイテッド・クリニカルデンティストリー"医歯薬出版. 418 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Y Imamura, S Shiiba, E Sakamoto, S Masumi, O Nakanishi, GJ Bennett: "Predicting Prognosis of Abnormal SensationsAfter Trigeminal Nerve Injury"Am Pain Soc Bulletin. (accepted).

    • Related Report
      2001 Annual Research Report
  • [Publications] Y Imamura, E Sakamoto, S Shiiba, S Masumi, O Nakanishi: "Prognosis of Prolonged Abnormal SensationsAfter Dental Treatment with quantitative sensory testing"Pain Research. 16. 83-89 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] E Sakamoto, S Shiiba, Y Imamura, S Masumi, O Nakanishi: "Evaluation ofnerve damage in traumatic trigeminal neuropathy with Neurometer"Pain Research. 16. 57-62 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y Imamura, JP Okeson: "Diagnosis of Chronic Orofacial Pain, in Management of Pain and Anxiety in Dental Office (eds. Dionne, Phero and Becker)"W.B.Saunders, Elsevier Science, Philadelphia. 418 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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