Grant-in-Aid for Scientific Research (C)
|Allocation Type||Single-year Grants |
|Research Institution||Kanazawa Medical University |
KANEYAMA K. Kanazawa Medical University, assistant professor, 医学部, 助手 (50329380)
SATO J Kanazawa Medical University, lecturer, 医学部, 講師 (60319069)
YOSHIMURA H Kanazawa Medical University, lecturer, 医学部, 講師 (90288845)
SEGAMI N Kanazawa Medical University, professor and chairman, 医学部, 教授 (40148721)
|Project Period (FY)
2001 – 2003
Completed (Fiscal Year 2003)
|Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
|Keywords||Temporomandibular joint disorder / synovial fluid / synovial tissue / pain related mediator / cytokine / neuro-mediated mechanism / osteoprotegerin / 関節液 / 関節組織 / 滑膜組織(関節組織) / 滑液(関節液) / 活性酸素 / 脳脊髄液 / 脳脊髄組織 / 顎関節|
1.Interleukin(IL)-6 may be associated with the development of osteoarthritis of the temporomandibular joint (TMJ). The detection of IL-8 correlated with the concentrations of IL-6 and tumor necrosis factor-α.
2.There was a correlation of concentrations between IL-6 and IL-11 in the condyle with osseous changes.
3.Synovial fluid in temporomandibular joint disorders(TMDs) with joint effusion contains higher concentrations of the protein and the IL-6 and -8, than without joint effusion.
4.Osteoprotegerin is associated with the development of degenerative changes of articular cartilage and may induce osteoarthritis of the TMJ.
5.Fibroblast growth factor 2 levels are elevated in the synovial fluid of the TMDs
6.Bradykinin in synovial fluid of the TMDs might be useful as an index of the degree of synovitis.
7.The expression of vascular endothelial growth factor in synovial tissues in TMDs.
8.The presence of IL-1 β and IL-6 in synovial fluid may be indicators of possible unsuccessful treatment following arthrocentesis for TMDs.
9.Arthrocentesis is good for washing out bradykinin, IL-6 and protein from the TMJ and the ideal lavage volume of perfusate for arthrocentesis is between 300 and 400 mL.
10.Arthroscopic antero-lateral capsular release using Ho-YAG laser is a effective surgical method for the treatment of arthralgia of TMJ.
11.The efficacy of carbamazepine is an auxiliary indicator of trigeminal neuralgia and the presence of a distinct trigger zone is a strong indicator of trigeminal neuralgia.
Our study shows that various mediators are involved in the pathogenesis in joints with TMD. The measurement of those activities in synovial fluid and tissues may provide some insight into their possible roles in joints with TMD. Further studies are underway to evaluate the pathology of TMD.