Experimental study of chemical transmitter of the swallowing center in the patients with dysphasia
| Project/Area Number |
13672140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Tohoku University |
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Principal Investigator |
SAITO Takashi Dental Hospital, Associate Professor, 歯学部附属病院, 助教授 (90005108)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Hiroshi Graduate School of Dentistry, Lecturer, 大学院・歯学研究科, 講師 (20108541)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | swallowing reflex / parasympathetic reflex / trigemonal spinal nucleus / vasodilation / lingual nerve / salivatory nucleus / 副交感神経 / 体性-副交感神経反射 / 孤束核 |
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| Research Abstract |
We examined whether the trigerainal spinal nucleus (Vsp) forms part of the central mechanism by which electrical stimulation of the central cut end of the lingual nerve (LN) evokes parasympathetic reflex vasodilatation in the lower lip in artificially ventilated, cervically vagosympathectomized cats deeply anesthetized with α-chloralose and urethane. For this purpose, we made microinjections within the brain stem to produce nonselective, reversible local anesthesia (lidocaine) or soma-selective, irreversible neurotoxic damage (kainic acid). Local anesthesia of Vsp by microinjection of lidocaine (2%; 1μl/site) reversibly and significantly reduced the ipsilateral-LN-evoked parasympathetic reflex vasodilatation. Unilateral microinjection of kainic acid(10mM/site; 1μl) into Vsp ipsilateral to the stimulated LN led to an irreversible reduction in the reflex vasodilatation but had no effect on the vasodilatation elicited by stimulation of the contralateral LN. Such microinjection of kainic acid into Vsp had no effect on the vasodilatation evoked by electrical stimulation of the ipsilateral inferior salivatory nucleus. Electrical stimulation of Vsp elicited a blood flow increase in the lower lip in an intensity- and frequency-dependent manner, regardless of whether systemic arterial blood pressure rose
Or fell. Hexamethonium (1.0mg/kg, I. v.) significantly reduced the vasodilator responses elicited by electrical stimulation of the central cut end of LN or Vsp, each to a similar degree. After hexamethonium, both vasodilator responses showed time-dependent recovery. These results strongly suggest that Vsp is an important bulbar relay for LN-evoked parasympathetic reflex vasodilatation in the cat lower lip.
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Report
(3 results)
Research Products
(3 results)
