Study for oral infectious control during peripheral blood stem cell transplantation
| Project/Area Number |
13672186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
TANIMOTO Ichiro Okayama University, Graduate School of Medicine and Dentistry, Research Associate, 大学院・医歯学総合研究科, 助手 (00280686)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Hideo Okayama University, University Hospital of Dentistry, Lecturer, 歯学部附属病院, 講師 (70222718)
MYOKAI Fumio Okayama University, Graduate School of Medicine and Dentistry, Research Associate, 大学院・医歯学総合研究科, 助手 (50263588)
MAEDA Hiroshi Okayama University, Graduate School of Medicine and Dentistry, Research Associate, 大学院・医歯学総合研究科, 助手 (00274001)
MINESHIBA Fumi Okayama University, Graduate School of Medicine and Dentistry, Research Associate, 大学院・医歯学総合研究科, 助手 (90346461)
NARUISHI Koji Okayama University, University Hospital of Dentistry, Research Associate, 歯学部附属病院, 助手 (00346446)
大山 秀樹 岡山大学, 大学院・医歯学総合研究科, 助手 (90280685)
村山 洋二 岡山大学, 大学院・医歯学総合研究科, 教授 (50029972)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2002: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2001: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | PBSCT / compromised host / oral infection control / periodontal desease / bacterial detection / leukocyte |
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| Research Abstract |
The oral infection control of the compromised patients during peripheral blood stem cell transport (PBSCT) is very important to prevent spreading the infection to other region. We should remove periodontopathic bacteria, but there is the possibility that the treatment without the consideration causes the exposure the blood vessel system to oral bacteria. The purpose of this research is the following 3 points. 1, Setting screening parameter item to quantify the oral infection. 2. Evaluate the progress during PBSCT. 3. Establish the oral bacteria detecting system from peripheral blood.
1. There 3 items were necessary to plan dentistry treatment of the PBSCT patients. Measurement of periodontal pocket depth, detection and quantification of periodontal pocket bacterial, and leukocyte quantification and qualification were important. 2. We had survey periodontal conditions and immune responses of 12 patients before/during/after PBSCT. Although there were differences in periodontal condition, or immune system responses, we succeed the control of periodontal infection with all the patients. 3. We established the oral bacterial detecting system. Using this system, we became possible to detect and quantify oral bacterial without time-consuming cultivation.
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Report
(3 results)
Research Products
(5 results)
