| Project/Area Number |
13672223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
IKEDA Kiyoshi University of Shizuoka, School of Pharmaceutical Sciences Associate Professor, 薬学部, 助教授 (40168125)
|
|---|
| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
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| Keywords | sialic acid / parainfluenza sialidase / sialidase inhibitor / hybrid-process / 2-deoxy-2, 3-dehydro-sialic acid / 2, 2-difluorosialic acid derivatives / シアリダーゼ阻害活性 / アドラーゼ / 2-デオキシ-2,3-デヒドロシアル酸 |
|---|
| Research Abstract |
Human parainfluenza virus is an important human pathogen causing upper and lower respiratory disease. To explore the influence on binding to sialidase from hPIV-1, modification of the hydroxyl group at the C-4 in 2β, 3β-difluorosialic acid derivatives and Neu5Ac2en derivatives was carried out. Synthesized compounds showed inhibitory activities against hPIV-1.
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