| Project/Area Number |
13672330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
医薬分子機能学
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| Research Institution | Department of Pharmacokinetics, Kyoto Pharmaceutical University |
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Principal Investigator |
HAKADA Kanji Kyoto Pharmaceutical University Department of Pharmacokinetics Professor, 薬物動態, 教授 (30102106)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Yukako Kyoto Pharmaceutical University Department of Pharmacokinetics Associate Professor, 薬物動態, 助手 (30278444)
SHIBATA Nobuhito Kyoto Pharmaceutical University Department of Pharmacokinetics Associate Professor, 薬物動態, 助教授 (60319449)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Glycopeptides / Labrasol / Vitamine E TPGS / Vancomycin / Gentamicin / Bioavailability / LC-MS-MS / Pharmacokinetics / ゲンタマイシン / 自己乳化型製剤 / 低バイオアベイラビリティ / 腸管排泄機構 |
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| Research Abstract |
We evaluated the mechanisms for poor permeability of aminoglycosides, vancomycin (VCM) and gentamicin (GM) in rats, and developed pharmaceutics of VCM and GM using an active surfactant, Labrasol. In addition, we developed a high sensitive LC/MS/MS method to determine VCM in plasma. The bioavailability of GM in self-micro-emulsifying drug delivery system (SMEDDS) using Labrasol increased by 50-100 folds as compared with a standard solution without Labrasol. The SMEDDS for VCM prepared by Labrasol and vitamin E TPGS at a weight ratio of 4:1 or addition of Eudragit also provided marked improvement in the VCM bioavailability after oral administration.
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