| Project/Area Number |
13672338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
医薬分子機能学
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| Research Institution | NATIONAL INSTITUTE OF HEALTH SCIENCES |
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Principal Investigator |
KURIHARA Masaaki NATIONAL INSTITUTE OF HEALTH SCIENCES, 有機化学部, 室長 (20205206)
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| Co-Investigator(Kenkyū-buntansha) |
宮田 直樹 国立医薬品食品衛生研究所, 有機化学部, 部長 (50114674)
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| Project Period (FY) |
2001 – 2002
|
| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | enediyne / Bergman reaction / trigger / DNA cleavage / 光照射 |
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| Research Abstract |
It is an interesting challenge to design alternate frameworks and triggering mechanisms, with the goal of producing a stable enediyne which can be activated under controlled conditions, especially in away which directs the cytotoxicity toward a specific pathogen or tissue.
I found simple trigger of cycloaromatization in enediyne system. This enediyne compound were activated by deprotection to cleave DNA.
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