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Effects of intake of K-containing food among passive-smoking pregnant women on prevention of neonatal bleeding

Research Project

Project/Area Number 13672525
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical nursing
Research InstitutionMie Prefectural College of Nursing

Principal Investigator

NAGAMI Keiko  Mie Prefectural College of Nursing, Nursing Science Department, Assistant Professor, 看護学部, 講師 (10218026)

Co-Investigator(Kenkyū-buntansha) MURASHIMA Seikou  Mie Prefectural College of Nursing, 看護学部, 教授 (20166276)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Keywordsvitamin K / cord blood / vitamin K-dependent clotting factor / passive smoking / neonate
Research Abstract

Study objective : The objectives of the present study were to elucidate the effects of passive smoking during pregnancy on changes in vitamin K-dependent clotting factor activity in cord blood, and to determine the effects of the intake of vitamin K-containing food among passive smoking pregnant women on prevention of neonatal bleeding, from the perspective of the transplacental supply of vitamin K.
Study methods : Subjects were 148 non-smoking women who underwent vaginal delivery (passive smoking group, n=53; non-passive smoking group, n=95). Consent was obtained following written and oral explanations. Following delivery, citric acid-added plasma obtained from collection of umbilical venous blood was used to investigate the following : prothrombin time, activated partial thromboplastin time, hepaplastin test, thrombotest, vitamin K-dependent clotting factor activity (FII, FVII, FIX, FX) and non-vitamin K-dependent clotting factor activity. In addition, a method for measuring vitamin K … More in cord blood was investigated based on Wakabayashi et al.(Folia Pharmacol.Jpn.116)'s HPLC using platinum catalyst reduction and electrochemical detection.
Results and discussion : The passive smoking group had significantly lower FVII and FIX than the non-passive smoking group. Comparison of the two groups with regard to the intake of fermented soybeans revealed a significantly higher FVII in the non-passive smoking group relative to the passive smoking group in the non-intake group, with no significant intergroup differences in the intake group. Comparison of the two groups with regard to the intake of broccoli revealed a significantly higher thrombotest value in the non-passive smoking group relative to the passive smoking group in the non-intake group, with no significant intergroup differences in the intake group. For pregnant women who may have difficulty avoiding passive smoking, regular intake of vitamin K-containing food may improve the activity of vitamin K-dependent clotting factors in fetal blood and thus provide a means of preventing early neonatal bleeding. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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