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Myocardial injury suffered by strenuous sports

Research Project

Project/Area Number 13680060
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionSt.Marianna University School of Medicine

Principal Investigator

MUSHA Haruki  St.Marianna University School of Medicine, Department of Internal Medicine, Professor, 医学部, 教授 (10182073)

Co-Investigator(Kenkyū-buntansha) NAGASHIMA Junzo  Yokohama Sports Medical Center, Internal Medicine, MD, 内科診療部, 医師 (60247351)
OHBA Haruo  Japan Institute of Sports Sciences, Department of Sports Medicine, MD, スポーツ医学研究部, 研究員 (40308416)
Project Period (FY) 2001 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordssudden cardiac death / exercise stress / myocardial injury / lons distance run / Sudden Cardiac Death / Exercise Stress / Myocardial injury / Long Distance Run / magnesium / atrial natriuretic peptide / brain natriuretic peptide / cardiac troponin T
Research Abstract

Cardiac sudden death during sports activity was the most important subject in sports medicine. Impaired cardiac function after strenuous exercise, such as an ultramarathon or triathlon, was so called ‘cardiac fatigue'. But, our past study showed impaired cardiac function was occurred by myocardial injury in an ultramarathon. In one of our results, the decrease of left ventricular contractility function was correlated.
In this study, levels of plasma atrial natriuretic peptide, brain natriuretic peptide, catecholamines, and cardiac troponin T were determined before and after a 100-km ultramarathon in 10 health men to examine the effects of the strenuous exercise on levels of atrial natriuretic peptide and brain natriuretic peptide and correlations between the natriuretic peptide and cardiac troponin T as a maker for myocardial injury. The levels of natriuretic peptide were strongly correlated with increased in cardiac trponin T level after the ultramarathon race.
Myocardial injury could d … More eveloped in some endurance athletes despite the absence of coronary arterial disease and idiopathic myocardial hypertrophy. The two mechanisms were thought as high catecholamines directly suffered cardiac muscle and coronary vasospasm with magnesium deficiency. The cardiac muscle was suffered from high concentration of free fatty acid produced by catecholamine-induced lypolysis. Intra-cellular magnesium ion deficiency and high catecholamine levels may be correlated with vasospastic angina, and the strenuous exercise induced hypomagnecemia and high catecholamine levels. The levels of serum magnesium ion levels and intra-cellular magnesium levels were not decreased before and after a 100km ultramarathon. In healthy runners, serum magnesium and intra-cellular magnesium did not decreased in strenuous exercise. The correlation between serum catecholamin levels and cardiac trponin T level were not significant. The direct catecholamin induced myocardial injury could not be proved in this study.
In conclusion, we thought that cardiac sudden death in sports activities was occurred by not only high catecholamin levels but also exercise induced vasospams with magnesium ion insufficiency, multiple factors might be effected on myocardial injury in a strenuous exercise. Less

Report

(5 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (2 results)

All 2001

All Journal Article (2 results)

  • [Journal Article] Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men.2001

    • Author(s)
      Haruo Ohba, et al.
    • Journal Title

      Am Heart J 141

      Pages: 751-758

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effects of prolonged strenuous exercise on plasma levels of atrial atrial natriuretic peptide and brain natriuretic peptide in healthy men.2001

    • Author(s)
      Haruo Ohba, Hideomi Takada, Haruki Musha, et al.
    • Journal Title

      Am Heart J 141

      Pages: 751-758

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary

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Published: 2001-04-01   Modified: 2016-04-21  

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