| Project/Area Number |
13680630
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
環境影響評価(含放射線生物学)
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| Research Institution | Nagasaki University |
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Principal Investigator |
OHWATARI Nobu Nagasaki Univ, Inst. Of Tropical Medicine, Associate Prof., 熱帯医学研究所, 助教授 (80128165)
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| Co-Investigator(Kenkyū-buntansha) |
TORIYAMA Kan Inst. Of Tropical Medicine, Assistant Prof., 熱帯医学研究所, 助教授 (00108359)
KUMATORI Atsushi Inst. Of Tropical Medicine, Assistant Prof., 熱帯医学研究所, 講師 (60244092)
FUJIMAKI Yasunori Inst. Of Tropical Medicine, Assistant Prof., 熱帯医学研究所, 講師 (10209083)
KANEDA Eiko Inst. Of Tropical Medicine, Research Associate, 熱帯医学研究所, 助手 (10253626)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Solar ultraviolet rays / Depression of immunity / Sick infection / Schistosomiasis mansoni / DDY mouse / Evaluation of UV influence / 紫外線 / マンソン住血吸虫 |
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| Research Abstract |
On this study, we experimented about a change of immunological ability induced by exposure of solar ultraviolet rays and an influence of the change on a sick infection, and examine whether ultraviolet rays participates in sick infection, or not. We used cercariae of Schistosoma mansoni for infectious experiments.
In results of artificial ultraviolet rays (UV-B) irradiation with 400 J/m^2 of UV-B, Schistosomiasis became worsen by UV-B irradiation, because both cercariae invaded into skin tissue and adult warm recovered increased significantly as comparison with non-irradiation group (p<0.01).
In solar light exposure contained with 400 J/m^2 of UV-B, there was not significant difference in numbers of each cercariae invaded into skin tissue and adult warm recovered as comparison with non-exposure group (control group).
In solar light irradiation contained with 800 J/m^2 of UV-B, the body temperature of mice increased by infrared rays, so we used with ice pack for restrain it by behavior ther
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mo-regulation. On immunity, CD4/CD8 in mice decreased to the significant minimum value in 7 days after solar light exposure, but it recovered in after 2 weeks. The cercariae invaded increased significantly compared with control group (p<0.05). However, it was not significant difference in adult warm recovered.
Further more in solar light exposure with 1600 J/m^2, we stopped infection experiments because damages induced by sunstroke in mice.
As considerations, the effective radiation dose of UV-B in solar light was high compared with artificial UV-B. It is guessed that continuous spectrum of solar light need much dose to get equal effects compared with discontinuity spectra of artificial UV-B.
Exposure to solar light at 800 J/m^2 of UV-B caused depression of immunity, and it enhanced cercariae to invade into skin tissue. These suggest that UV-B in solar light becomes worsen in infection of Schistosomiasis. Furthermore, wemust investigate for human health about growing up of cercariae in the body with solar light exposure through experiments over 800 J/m^2 with temperature control equipment. Less
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