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Role of the neuronal glutamate transporter in neurological disorders

Research Project

Project/Area Number 13680824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyushu University

Principal Investigator

FURUTA Akiko  Kyushu University, Graduate School of Medical Sciences, Neuropathology, Instructor, 大学院・医学研究院, 助手 (50229118)

Co-Investigator(Kenkyū-buntansha) IWAKI Toru  Kyushu University, Graduate School of Medical Sciences, Neuropathology, Professor, 大学院・医学研究院, 教授 (40221098)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsglutamate transporter / epilepsy / brain ischemia / EAAC1 / EAAT3 / Golgi complex / neuronal cell death
Research Abstract

Glutamate transporters are thought to have a role for preventing the excitotoxicity in the various neurological disorders including epilepsy, hypoxia-ischemia and neurodegenerative diseases. We have demonstrated that neuronal glutamate transporter subtype EAAC1 (EAAT3) exhibited dynamic changes in the hypoxia-ischemia and epilepsy. In the rat neonatal hypoxia-ischemia, expression of EAAC1 increased in the border area (penumbra). Therefore, EAAC1 in neurons may be induced by hypoxic-ischemic insult. In the kainate-induced rat epilepsy, we found that EAAC1 was transiently translocated from the plasma membrane to the Golgi complex in the large pyramidal neurons during the post-ictal state. This phenomenon was also observed dysplastic neurons in focal cortical dysplasia, which is often epileptogenic. The changes of subcellular localization of EAAC1 may be important for neuronal protection because it could prevent excessive uptake of glutamate. Further studies for EAAC1 function are conducted in vitro with GFP-tagged EAAC1 to elucidate the mechanism of internalization.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Fukamachi, S.et al.: "Altered expression of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia"Dev.Brain Res.. 132. 131-139 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nabekura, J.et al.: "Reduced NR2A expression and prolonged decay of NMDA receptor-mediated synaptic current in rat vagal motoneurons following axotomy"J.Physiol.. 539. 735-741 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nabekura, J.et al.: "Reduction of KCC2 expression and GABAA receptor-mediated excitation following in vivo axonal injury"J Neurocsi.. 22. 4412-4417 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fukamachi S., Furuta A., Ikeda T., Ikenoue T., Rothstein JD., Iwaki T.: "Altered expression of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia"Dev Brain Res. 132. 131-139 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nabekura J., Ueno T., Katsurabayashi S., Furuta A., Akaike N., Okabe M.: "Reduced NR2A expression and prolonged decay of NMDA receptor-mediated synaptic current in rat vagal motoneurons following axotomy"J Physiol. 539. 735-741 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Namekura J., Ueno T., Okabe A., Furuta A., Iwaki T., Shimizu-Okabe C., Fukuda A., Akaike N.: "Reduction of KCC2 expression and GABAA receptor-mediated excitation following in vivo axonal injury"J Neurosci. 22. 4412-4417 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fukamachi, S, Furutq, A. et al.: "Altered expression of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia"Developmental Brain Research. 132. 131-139 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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