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Neurotrophic effects of Radicicol on Sensory Neurons

Research Project

Project/Area Number 13680848
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

SANO Mamoru  Kyoto Prefectural University of Medicine, Professor, 医学研究科, 教授 (60090429)

Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsradicicol / geldanamycin / Hsp90 / NF108-15 / N2a / DRG / ラディシコール / ゲルダナマイシン / ニューロトロフィン / 知覚神経節
Research Abstract

Radicicol and geldanamycin, Hsp9O-binding antibiotics, potentiate neurite growth and survival of cultured sensory neurons from chick embryo. They did not exhibit trophic effects on the sensory neurons from embryonic and adult rats and mice. We show that the antibiotics induced the outgrowth of neurites in NG108-15 cells and N2A cells. Treatment of cells with these drugs decreased levels of Raf1,ERK1/2 and phosphorylated ERK1/2 time-dependently. Levels of Akt1 and CDK4 were slightly decreased. The neurite growth by the drugs was blocked by actynomycin D. The neurite growth of NG108-15 cells Geld might be due to a change in the synthesis of some specific protein(s).

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Sakuma K.: "A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of ratsubjected to mechanical overload, bupivacaine injection and axotomy."Brain Res. 907. 1-19 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kotani T.: "Circular nuclear alignment in multinucleats PL12D cells produced by cell fusion with polyethylene glycol"Acta Hisochem.Cytochem.. 35. 185-191 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma K.: "The reciprocal change of neurotrophin-4 and glial cell line-derived neurotrophic factor protein in the muscles, spinal cord and cerebellum of the dy mouse"Acta Neurophathologica. 104. 482-492 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma K.: "Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2"Acta Neurophathologica. 105. 271-280 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma K.: "Serum response factor plays an important role in the mechanically overloaded plantaris muscle of rats"Histochem.Cell Biol.. 119. 149-160 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonezawa S.: "Possible involvement of myosin-X in intercellular adhesion: importance of serial pleckstrin homology regions for intracellular localization."Develop. Growth Differ.. 45. 175-185 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sano, M.: "Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons."Neuropharmacology. 40. 947-953 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fukuzumi, M.: "Comparison of expression of cell surface poly-N-acetyl lactosamin type oligosaccarides in PC12 cells with these in its variant PC12D."Glicobiology. 11. 481-494 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishikawa, T.: "Peroxisomes exist in growth cones and move anterogradely and retrogradely in neurites of PC12D cells."Exp. Cell Res.. 266. 260-269 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma, K.: "A possible role for BDNF, NT-4 and Trk B in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomy."Brain Res.. 907. 1-19 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kotani, T.: "Circular nuclear alignment in multinuleate PC12D cells produced by cell fusion with polyethylene glycol."Acta Histochemica et Cytochemica. 35. 185-191 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma, K.: "The reciprocal change of neurotrophin-4 and glial cell line-derived neurotrophic factor protein in the muscles, spinal cord and cerebellum of the dy mouse."Acta Neuropathologica. 104. 482-492 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma, K.: "Calcinurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2."Acta Neuropathologica. 105. 271-280 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma, K.: "Serum response factor plays an important role in the mechanically overloaded plantaris muscle of rats."Histochem. Cell Biol.. 119. 149-160 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yonezawa, S.: "Possible involvement of myosin-X in intercellular adhesion : Importance of serial pleckstrin homology regions for intracellular locarization."A.Develop. Growth Differ.. 45. 175-185 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sakuma K.: "Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2"Acta Neurophathologica. 105. 271-280 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakuma K.: "Serum response factor plays an important role in the mechanically overloaded plantaris muscle of rats"Histochem.Cell Biol.. 119. 149-160 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yonezawa S.: "Possible involvement of myosin-X in intercellular adhesion : Importance of serial pleckstrin homology"Develop.Growth Differ.. 45. 125-185 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sakuma K.: "The reciprocal change of neurotrophin-4 and glial cell line-derived neurotrophic factor protein in the muscles, spinal cord and cerebellum ・・・"Acta Neuropathologica. 104. 482-492 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kotani T.: "Circular nuclear alignment in multinucleate PC12D cells produced by cell fusion with polyethylene glycol"Acta Histochemica Cytochemica. 35. 185-191 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sakuma K.: "Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2"Acta Neuropathologica. 105. 271-280 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] SANO, M.: "Radicicol and geldana mycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons"Nourophar macology. 40. 947-953 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] FUKUZUMI, M.: "Comparison of expression of cell surface poly-N-acetyl lactosamine type oligosaccarides in PC12 cells with these in ・・・"Glico biology. 11. 481-494 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] ISHIKAWA, T.: "Peroxisomls exist in growth cones and move antro gradely and retro gaudery in neurios of PC12D cells"Experimental Cell Research. 266. 260-269 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] SAKUMA, K.: "A possible role for BDNF, NT-4 and TrkB in the spinal coed and muscle of rat subjected to meohevical overdood"Brain Research. 907. 1-19 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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