| Project/Area Number |
13680890
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Okazaki National Research Institutes (2002-2003)
Tokyo Metropolitan Organization for Medical Research (2001) |
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Principal Investigator |
NAMBU Atsushi Okazaki National Research Institutes, National Institute for Physiological Sciences, Professor, 生理学研究所, 教授 (80180553)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | Basal ganglia / Subthalamic nucleus / Globus pallidus / Hyperdirect pathway / Direct pathway / Indirect pathway / Motor control / Parkinson's disease / 関節路 / GABA / グルタミン酸 |
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| Research Abstract |
The functional significance of the cortico-subthalamo-pallidal "hyperdirect" pathway has been investigated, and a dynamic "center-surround model" of basal ganglia function in the control of voluntary limb movements has been suggested. When a voluntary movement is about to be initiated by cortical mechanisms, a corollary signal conveyed through the "hyperdirect" pathway first inhibits large areas of the thalamus and cerebral cortex that are related to both the selected motor program and other competing programs. Then, another corollary signal through the cortico-striato-pallidal "direct" pathway disinhibits their targets and releases only the selected motor program. Based on this model, akinesia observed in Parkinson disease could better be explained by reduced disinhibition in the thalamus and cortex through the "direct" pathway in the spatial and temporal domains. Amelioration of akinesia after subthalamic lesion could also be understood by restored disinhibition in the thalamus and cortex.
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