ステロイド合成細胞のクロノメタボリズム：細胞代謝と生理の概日時計による制御機構
| Project/Area Number |
13F03402
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
岡村 均 京都大学, 薬学研究科(研究院), 教授 (60158813)
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| Co-Investigator(Kenkyū-buntansha) |
CHEN HUATAO 京都大学, 薬学研究科(研究院), 外国人特別研究員
CHEN Huatao 京都大学, 薬学研究科(研究院), 外国人特別研究員
CHEN Huatao 京都大学, 薬学研究科, 外国人特別研究員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2015: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2014: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2013: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | circadian / ステロイド / アルドステロン / 脂肪 / 生体リズム / 転写制御 / 時計遺伝子 |
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| Outline of Annual Research Achievements |
On our planet, the earth’s rotation around the sun brings about a 24-h light-dark cycle that shapes the lifestyle of all living organisms. In anticipation of and adaption to those predictable cyclic light signals, most organisms have evolved to exhibit diurnal dynamic behavioral and physiological rhythms, known simply as circadian rhythms. In mammals with an intact body system, circadian rhythms are ubiquitous, residing not only in the suprachiasmatic nucleus (SCN; also known as the central pacemaker of the circadian clock) but also in various peripheral tissues (regarded as peripheral circadian oscillator). The molecular machinery underlying circadian clocks in the SCN and peripheral tissues is composed of a conservative interlocked transcriptional-translational feed-back loop involving multiple clock genes and their protein products that are required for generating endogenous circadian oscillations. We examined chronometaolism in steroid synthetic organs such as ovary and adrenal glands. During the course of study, we noticed that steroid metabolism interlocks with many other metabolisms, and liver is a key organ of most metabolisms. To understand the whole context of chronometabolism, we choosed liver, and we began a study of fundamental energy source, glycogen. We investigated the effect of hepatic clock and food on hepatic glycogen storage using Period genes deficient mice and wild type mice, and found that glycogen storage was strongly regulated by the circadian clock. We are now investigating the interlocks of glucose and steroid metabolisms.
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| Research Progress Status |
27年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
27年度が最終年度であるため、記入しない。
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Isoform-specific monoclonal antibodies against 3beta-hydroxysteroid dehy drogenase/isomerase family provide markers for subclassification of hum an primary aldosteronism. .2014
Author(s)
Doi M, Satoh F, Maekawa T, N akamura Y, Fustin JM, Tainaka M, Hotta Y, Takahashi Y, Morimoto R, Takase K, Ito S, Sasano H, and Okamura H
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Journal Title
J Clin Endocrinol Metab
Volume: 99
Issue: 2
Pages: 257-62
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunolocalization of murine type VI 3β-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta2014
Author(s)
Koki Yamamura, Magao Doi, Hida Hayashi, Takumi Ota, Iori Murai, Yunhong Hotta, Rie Komatsu, Hitoshi Okamura
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Journal Title
Molecular and Cellular Endocrinology
Volume: 382
Issue: 1
Pages: 131-138
DOI
Related Report
Peer Reviewed
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