哺乳類卵胞の選択的死滅制御機構とその人為支配による潜在的卵巣卵の利用

• Project/Area Number: 13GS0008
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo (2004-2005); Kyoto University (2001-2003)
• Principal Investigator: 眞鍋 昇 東京大学, 大学院農学生命科学研究科, 教授 (80243070)
• Co-Investigator(Kenkyū-buntansha): 宮野 隆 神戸大学, 農学部, 教授 (80200195) ; 酒巻 和弘 京都大学, 生命科学研究科, 助教授 (20271017) ; 若山 照彦 理化学研究所, 神戸研究所・発生再生科学総合研究センター, チームリーダー(研究職) (40360672) ; 杉本 実紀 京都大学, 農学研究科, 助手 (20243074) ; 中山 瑞穂 京都大学, 農学研究科・日本学術振興会, 特別研究員(PD)
• Project Period (FY): 2001 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥347,750,000 (Direct Cost: ¥288,200,000、Indirect Cost: ¥59,550,000); Fiscal Year 2005: ¥83,850,000 (Direct Cost: ¥64,500,000、Indirect Cost: ¥19,350,000); Fiscal Year 2004: ¥84,500,000 (Direct Cost: ¥65,000,000、Indirect Cost: ¥19,500,000); Fiscal Year 2003: ¥89,700,000 (Direct Cost: ¥69,000,000、Indirect Cost: ¥20,700,000); Fiscal Year 2002: ¥89,700,000 (Direct Cost: ¥89,700,000)
• Keywords: 哺乳類 / 卵巣 / 卵胞 / 選択的死滅 / アポトーシス / 細胞死受容体 / 細胞内シグナル伝達阻害因子 / 異種移植 / カスパーゼ

Research Abstract

脊椎動物は多様な生殖戦略をもつ。魚類の多くは数万〜数億のなかで幸運で優れた仔だけが生き残る。逆に、哺乳類は性周期毎に1〜10個の卵母細胞を排卵し、極わずかの仔を産み、それを大切に育てる。成熟した哺乳類卵巣には、胎児期に減数分裂の途中・ディプロテン期で休止した5〜100万個の卵母細胞が含まれ、これが性周期毎に発育・成熟して排卵に至る。この過程で、最終的に排卵にいたるものの100倍以上の卵胞が発達を開始し、99%以上が選択的に死滅する。この卵胞の選択的死滅は優秀で強靭な子孫を残す戦略として重要であるが、これを調節している分子制御機構は未解明である。本研究は、哺乳類卵巣において繰返される卵胞の選択的死滅を支配している分子機構を解明し、これをもとに細胞死を制御している遺伝子の発現をin vivo制御することで卵胞発育を人為的に支配しようとするものである。この新技術で、食肉処理場で捨てられる卵巣内の卵母細胞の有効利用を実現しようとしている。今年度は実証的研究に注力した。卵胞顆粒層細胞に特異的に発現している新規細胞死受容体を認識するユニークなモノクロナル抗体を用いてデコイ受容体を同定し、その発現動態を明らかとした。さらに細胞死受容体を介する細胞内アポトーシスシグナル伝達系を担うカスパーゼ系を阻害するcFLIPを見いだして遺伝子とアミノ酸配列を決定した。これの発現を腫瘍壊死因子α調節し、その制御に多面的機能をもつinterleukin-6が重要に関わっていることを示唆した。併行して、大型家畜の未成熟な卵胞を含む卵巣片を免疫不全マウス腎漿膜嚢に異種移植し、in vivo遺伝子導入とRNA発現阻止(iRNA)にて人為的に制御できるシステムを開発した。

Research Products

• [Journal Article] Erythropoietion-producing cells in the liver of ICR-derived glomerulonephritis (ICGN)mice. (2006)
  • Author(s): Misuzu Yamaguchi-Yamada, Naotsugu Akashi, Yasufumi Goto, Sayuri Anan, Yoshie Yamamoto, Atsuo Ogura, Noboro Manabe
  • Journal Title: The Journal of Veterinary Medical Science 68 Pages: 65-68
• [Journal Article] Propagation of an infertile hermaphrodite mouse lacking germ cells, using nuclear transfer and embryonic stem cell technology. (2005)
  • Author(s): Wakayama S, Kishigami S, Van Thuan N, Ohta H, Hikishi T, Mizutani E, Yanagimashi R, Wakayama T.
  • Journal Title: Proceeding of National Academic Sciences in USA 102 Pages: 29-33
• [Journal Article] Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia. (2005)
  • Author(s): Fujita, K., Ohta, H., Thujimura, A., Takao, T., Miyagawa, Y., Takada, S., Matsumiya, K., Wakayama, T., Okuyama,A.
  • Journal Title: Journal of Clinical Invesigation 115 Pages: 1855-1861
• [Journal Article] Generation of progeny from embryonic stem cells by microinsemination of male germ cells from chimeric mice. (2005)
  • Author(s): Mizutani E, Ohta H, Kishigami S, Van Thuan N, Hikichi T, Wakayama S, Sato E, Wakayama T.
  • Journal Title: Genesis 43 Pages: 34-42
• [Journal Article] Changes in expression of anti-apoptotic protein, cFLIP,in granulosa cells during follicular atresia in porcine ovaries. (2005)
  • Author(s): Fukuo Matsuda-Minehata, Yasufumi Goto, Naoko Inoue, Noboru Manabe
  • Journal Title: Molecular Reproduction and development 72 Pages: 145-151
• [Journal Article] Birth of Offispring after Transfer of Mongolian Gerbil(Meriones unguiculatus)Embryos Cryopreserved by Vitrification. (2005)
  • Author(s): Mochida K, Wakayama T, Takano K, Noguchi Y, Yamamoto Y, Suzuki O, Matsuda J, Ogura A
  • Journal Title: Molecular Reproduction and Development 70 Pages: 464-470
• [Journal Article] Effects of long-term grafting on follicular growth in porcine ovarian cortical grafts xenoplanted to severe combined immunodeficient(SCID)mice. (2005)
  • Author(s): Noriko Kagawa, Yohichiro Sakurai, Takashi Miyano, Noboru Manabe
  • Journal Title: Journal of Reproduction and Devevelopment 51 Pages: 77-85
  • NAID: 10020372550
• [Journal Article] Ovarian activity and oocyte development during follicular development in pigs at different reproductive phases estimated by the repeated endoscopic method. (2005)
  • Author(s): Jozsef Ratky, Helmut Torner, Istvan Egerszegi, Falk Schneider, Peter SarlOs, Noboru Manabe, Klaus-Peter Brussow
  • Journal Title: Journal of Reproduction and Devevelopment 51 Pages: 253-263
  • NAID: 110004704726
• [Journal Article] Conflict of estrogenic activity by various phthalates between in vitro and in vivo models related to the expression of Calbindin-D_<9K+> (2005)
  • Author(s): Eui-Ju Hong, Youn-Kyu Ji, Kyung-Chul Choi, Noboro Manabe, Eui-Bae Jeung
  • Journal Title: Journal of Reproduction and Devevelopment 51 Pages: 253-263
  • NAID: 10027324521
• [Journal Article] Effects of in utero exposure to bisphenol A on mRNA expression of arylhydrocarbon and retinoid receptors in murine embryos. (2005)
  • Author(s): Hanako Nishizawa, Maki Morita, Miki Sugimoto, Stoshi Imanishi, Noboru Manabe
  • Journal Title: Journal of Reproduction and devevelopement 51 Pages: 315-324
  • NAID: 10027324772
• [Journal Article] Comparison of follicular and oocyte development and reproductive hormone secretion during the ovulatory period in hungarian native breed,Mangalica,and Landrace gilts. (2005)
  • Author(s): Jozsef Ratky, Klaus-Peter Brussow, Istvan Egerszegi, Hwlmut Torner, Falk Schneider, Laszlo Solti, Noboru Manabe
  • Journal Title: Journal of Reproduction and devevelopement 51 Pages: 427-432
  • NAID: 10027325210
• [Journal Article] Effects of exposure in utero to bisphenol A on the expression of arylhydrocarbon receptor,related factors and xenobiotic metabolizing enzymes in murine embryos. (2005)
  • Author(s): Hanako Nishizawa, Satoshi Imanishi, Noboru Manabe
  • Journal Title: Journal of Reproduction and devevelopement 51 Pages: 593-605
  • NAID: 10027325900
• [Journal Article] Chenges in expression and localization of connexin 43 mRNA and protein in porcine ovary granulosa cells during follicular atresia. (2005)
  • Author(s): Yuan Cheng, Naoko Inoue, Fuko Matsuda-Minehata, Yasufumi Goto, Akihisa Maeda, Noboru Manabe
  • Journal Title: Journal of Reproduction and devevelopement 51 Pages: 627-637
• [Journal Article] Growth and maturation of porcine follicles and oocytes following xenotransplantation of ovarian tissues and in vitro maturation culture. (2005)
  • Author(s): Noriko Kagawa, Takashi Miyano, Noboru Manabe
  • Journal Title: Journal of Reproduction and devevelopement 51 Pages: 741-748
• [Journal Article] In vitro growth of mammalian oocytes. (2005)
  • Author(s): Miyano T.
  • Journal Title: Journal of Reproduction and devevelopement 51 Pages: 169-176
• [Journal Article] Transfroming growth factor-β1 mediated up-regulation of lysyl oxidase in the kidneys of hereditary nephrotic mouse with chronic renal fibrosis. (2005)
  • Author(s): Yasufumi Goto, kozue Uchio-Yamada, Anan Sayuri, Yoshie Yamamoto, Atsuo Ogura, Noboru Manabe
  • Journal Title: Virchowx Archiv 447 Pages: 859-868
• [Journal Article] Decreased expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in the kidneys of hereditary nephrotic(ICGN)mice. (2005)
  • Author(s): Kozue Uchio-Yamada, Noboru Manabe, Yasufumi Goto, Sayuri Anann, Yoshie Yamamoto, Kaoru Takano, Atsuo Ogura, Junichiro Matsuda
  • Journal Title: The Journal of Veterinary Medical Science 67 Pages: 35-41
  • NAID: 130000448457
• [Journal Article] Dysfunction of erythropoietin-producing interstitial cells in the kidneys of ICR-derived glomerulonephritis (ICGN)mice. (2005)
  • Author(s): Misuzu Yamaguchi-Yamada, Noboru Manabe, Minako Kiso, Yasufumi Goto, Toshiharu Mori, Chinatsu Sakata, Sayuri Anan, Masaya Nagao, Yoshie Yamamoto, Atsuo Ogura
  • Journal Title: The Journal of Veterinary Medical Science 67 Pages: 891-899
  • NAID: 110003983159
• [Journal Article] Effect of human erythropoietin (hEPO)treatment on anemia in ICR-derived glomerulaonephrosis(ICGN)mice. (2005)
  • Author(s): Yohei Miyamoto, Keiko Kuramitsu-Miyamoto, Ema Iwanaga, Kozue Uchio-Yamada, Misuzu Yamaguchi-Yamada, Atsuo Ogura, Noboru Manabe
  • Journal Title: Experimental Animal 54 Pages: 181-184
• [Journal Article] Disposition of disphenol A in pregnant mice and fetuses after a single and repeated oral administration. (2005)
  • Author(s): Yuko Kawamoto, Wakoto Matsuyama, Masahiro Morikawa, Maki Morita, Miki Sugimoto, Moboru Manabe, Shinsuke Morisawa
  • Journal Title: Toxicological and Environmental Chemistry 87 Pages: 199-213
• [Journal Article] Effects of dietary supplementation with branched-chain amino acids(BCAAs)during nursing on plasma BCAA levels and subsequent growth in cattle. (2005)
  • Author(s): Jun-You Li, Kazumi Suzuki, Yukihiro Koike, DS Chen, Tomohiro Yonezawa, Masugi Nishihara, Noboru Manabe
  • Journal Title: Asian Australian Journal of Animal Science 18 Pages: 1440-1444
• [Journal Article] New preservation method for mouse spermatozoa without freezing. (2005)
  • Author(s): Van Thuan N, Wakayama S, Kishigami S, Wakayama T
  • Journal Title: Biology of Reproduction 72 Pages: 444-450
• [Journal Article] Establishment of male and female nuclear transfer embryonic stem cell lines from different mouse strains and tissues. (2005)
  • Author(s): Wakayama S, Ohta H, Kishigami S, Van Thuan N, Hikichi T, Mizutani E, Miyake M, Wakayama T
  • Journal Title: Biology of Reprodution 72 Pages: 932-936
• [Journal Article] Changes in expression of anti-apoptotic protein, cFLIP, in granulose cells during follicular atresia in porcine ovaries.(review) (2005)
  • Author(s): Noboru Manabe, Fuko Matsuda-Minehata, Yasufumi Goto, Akihisa Maeda, Yuan Cheng, Takafumi Sai, Miyuki Kohori, Maiko Endo, Junyou Li
  • Journal Title: European Journal of Cellular and Molecular Physiopathology 44 Pages: 120-124
• [Journal Article] Anti-apoptotic activity of porcine cFLIP in ovarian grabulosa cell lines.(review) (2005)
  • Author(s): Noboru Manabe, Fuko Matsuda-Minehata, Yasufumi Goto, Akihisa Maeda, Yuan Cheng, Takafumi Sai, Miyuki Kohori, Maiko Endo, Junyou Li
  • Journal Title: European Journal of Cellular and Molecular Physiopathology 44 Pages: 125-129
• [Journal Article] Molecular cloning of porcine; cellular flice-like inhibitory protein.(review) (2005)
  • Author(s): Noboru Manabe, Fuko Matsuda-Minehata, Yasufumi Goto, Akihisa Maeda, Yuan Cheng, Takafumi Sai, Miyuki Kohori, Maiko Endo, Junyou Li
  • Journal Title: European Journal of Biology and Chemistry of Proteins 18 Pages: 201-204
• [Journal Article] Changes in the expression of bid in granulosa cells during follicular atresia in pig ovaries.(review) (2005)
  • Author(s): Noboru Manabe, Fuko Matsuda-Minehata, Yasufumi Goto, Akihisa Maeda, Yuan Cheng, Takafumi sai, Miyuki Kohori, Maiko Endo, Junyou Li
  • Journal Title: European Journal of Biology and Chemistry of Proteins 18 Pages: 205-208
• [Journal Article] Characteristics of initiation and early events for muscle development in the Xenopus limb bud. (2005)
  • Author(s): Satoh A., Sakamaki K., Ide H., Tamura K.
  • Journal Title: Developmenta Dynamics 234 Pages: 846-857
• [Journal Article] Expression and functional analysis of genes deregulated in mouse placental over growth models : Car2 and Ncaml. (2005)
  • Author(s): Singh U, Sun T, Shi W, Schulz R, Nuber UA, Varanou A, Hemberger MC, Elliott RW, Ohta H, Wakayama T, Fundele R
  • Journal Title: Developmenta Dynamics 234 Pages: 1034-1045
• [Journal Article] Germinal vesicle materials are requisite for male pronucleus formation but not for change in the activities of CDKI and MAP kinase during maturation and fertilization of pig oocytes (2005)
  • Author(s): Ogushi S, Fulka J Jr, Miyano T
  • Journal Title: Developmental Biology 286 Pages: 287-298
• [Journal Article] Generation of normal progeny by intracytoplasmic sperm injection following grafting of testicular tissue from cloned mice that died postnatally. (2005)
  • Author(s): Ohta H, Wakayama T
  • Journal Title: Biology of Reproduction 73 Pages: 390-395
• [Journal Article] Interleukin-6 regulates the expression of cellular FLICE-like inhibitory protein in granulose cells of ovaries.(abstrqact) (2005)
  • Author(s): Akihisa Maeda, Yasufumi goto, Fuko Matsuda-Minehata, Yuan Cheng, Takafumi Sai, Noboru Manabe
  • Journal Title: Biology of Reproduction 70 Pages: 115-116
• [Journal Article] Granulosa cell is a typr II apoptotic cell that regulates follicular atresia in pig ovaries.(abstrqact) (2005)
  • Author(s): Takafumi Sai, Toshikatsu Matsui, Yasufumi Goto, Fuko Matsuda-Minehata, Naoko Inoue, Akihisa Maeda, Yuan Cheng, Noboru Manabe
  • Journal Title: Biology of Reproduction 70 Pages: 116-117
• [Journal Article] CFLIP regulates granulose cell apoptosis during follicular atresia in porcine ovaries.(abstrqact) (2005)
  • Author(s): Fuko Matsuda-Minehata, Yasufumi Goto, Naoko Inoue, Noboru Manabe
  • Journal Title: Biology of Reproduction 70 Pages: 118-119
• [Journal Article] Apoptosis is regulated by soluble Fas during luteolysis in Iuteal cells of mouse ovaries.(abstrqact) (2005)
  • Author(s): Noboru Manabe, Kohji Komatsu, Minako Kiso, Yasufumi Goto, Sayuri Anan, Junyou Li
  • Journal Title: Biology of Reproduction 70 Pages: 122-123
• [Journal Article] Connexin-43 has relation to regulation of granulosa cell apoptosis during atresia in pig ovarian follicules. (abstrqact) (2005)
  • Author(s): Yuan Cheng, Naoko Inoue, Fuko Matsuda-Minegishi, Yasufumi Goto, Akihisa Maeda, Junyou Li, Noboru Manabe
  • Journal Title: Biology of Reproduction 70 Pages: 124-125
• [Journal Article] Changes in the expression of Bid in granulosa cells during follicular atresia in pig ovaries.(abstrqact) (2005)
  • Author(s): Naoko Inoue, Ryosuke Yoshioka Yasufumi Goto, Fuko Matsuda-Minehata, Akihisa Maeda, Yuan Cheng, Noboru Manabe
  • Journal Title: Biology of Reproduction 70 Pages: 223-224
• [Journal Article] Round spermatids stained with mitotracker can be used to produce offspring more simply (2005)
  • Author(s): Hikichi T, Kishigami S, Thuan NV, Ohta H, Mizutani E, Wakayama S, Wakayama T.
  • Journal Title: Zygote 13 Pages: 55-61
• [Journal Article] Propagation of an infertile hermaphrodite mouse lacking germ cells by using nuclear transfer and embryonic stem cell technology. (2005)
  • Author(s): Wakayama, S., Kishigami, S., Van Thuan, N., Ohta, H., Hikichi, T., Mizutani, E., Yanagimachi, R., Wakayama, T.
  • Journal Title: Proceedings of National Academy of Science USA 102・1 Pages: 29-33
• [Journal Article] A caspase-8-independent signalling pathway activated by Fas ligation leads to exposure of Bax N-terminus. (2005)
  • Author(s): Lilin Zhang, Shigeomi Shimizu, Kazuhiro, Sakamaki, Shin Yonehara, Yoshihide Tsujimoto
  • Journal Title: Journal of Biological Chemistry 279・10 Pages: 33865-33874
• [Journal Article] The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity. (2005)
  • Author(s): Kazuhiro Sakamaki, Chiyo Takagi, Katsuya Kominami, Shin-ichi Sakata, Yoshio Yaoita, Hiroshi Y. Kubota, Masami Nozaki, Shin Yonehara, Naoto Ueno
  • Journal Title: Genes to Cells 9・5 Pages: 1249-1264
• [Journal Article] Birth of offspring after transfer of mongolian gerbil (Meriones unguiculatus) embryos dryopreserved by vitrification. (2005)
  • Author(s): Mochida K, Wakayama T, Takano K, Noguchi Y, Yamamoto Y, Suzuki O, Matsuda J, Ogura A.
  • Journal Title: Molecular Reproduction and Development 70・1 Pages: 464-470
• [Journal Article] Decreased expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in the kidneys of hereditary nephrotic (ICGN) mice. (2005)
  • Author(s): Kozue Uchio-Yamada, Noboru Manabe, Yasufumi Goto, Sayuri Anann, Yoshie Yamamoto, Kaoru Takano, Atsuo Ogura, Junichiro Matsuda
  • Journal Title: The Journal of Veterinary Medical Science 67・1 Pages: 35-41
  • NAID: 130000448457
• [Journal Article] On the road to therapeutic cloning. (2004)
  • Author(s): Wakayama, T.
  • Journal Title: Nature Biotechnology 22・1 Pages: 399-400
• [Journal Article] Production of fertile offspring from genetically infertile male mice. (2004)
  • Author(s): Yanagimachi, R., Wakayama, T., Kishikawa, H., Fimia, G.M., Monaco, L., Sassone-Corsi, P.
  • Journal Title: Proceedings of National Academy of Science USA 101・3 Pages: 1691-1695
• [Journal Article] Involvement of histone H3 (Ser10) phosphorylation in chromosome condensation without Cdc2 kinase and mitogen-activated protein kinase activation in pig oocytes. (2004)
  • Author(s): Hong-Thug Bui, Emi Yamaoka, Takashi Miyano
  • Journal Title: Biology of Reproduction 70・6 Pages: 1843-1851
• [Journal Article] Activation of p38 MAPK during porcine oocyte maturation. (2004)
  • Author(s): Luis G.Villa-Diaz, Takashi Miyano
  • Journal Title: Biology of Reproduction 71・2 Pages: 691-696
• [Journal Article] Simila time restriction for intracytoplasmic sperm injection and round spermatid injection into activated oocytes for efficient offspring production. (2004)
  • Author(s): Kishigami, S., Wakayama, S., Nguyen, V.T., Wakayama, T.
  • Journal Title: Biology of Reproduction 70・6 Pages: 1863-1869
• [Journal Article] Commitment of fetal male germ cells to spermatogonial stem cells during mouse embryonic development. (2004)
  • Author(s): Ohta, H., Wakayama, T., Nishimune, Y.
  • Journal Title: Biology of Reproduction 70・5 Pages: 1286-1291
• [Journal Article] New preservation method for mouse spermatozoa without freezing. (2004)
  • Author(s): Van Thuan, N., Wakayama, S., Kishigami, S., Wakayama, T.
  • Journal Title: Biology of Reproduction 72・1 Pages: 444-450
• [Journal Article] Effect of caffeine on meiotic maturation of porcine oocytes. (2004)
  • Author(s): Radomir Kren, Sugako Ogushi, Takashi Miyano
  • Journal Title: Zygote 12・1 Pages: 31-38
  • NAID: 120001460015
• [Journal Article] Xenografting of bovine secondary follicles into ovariectomized female severe combined immunodeficient mice. (2004)
  • Author(s): Shoichiro Senbon, Atsushi Ota, Masao Tachibana, Takashi Miyano
  • Journal Title: Journal of Reproduction and Development 50・4 Pages: 134-140
  • NAID: 10027322921
• [Journal Article] Cellular functions of mitogen-activated protein kinases and protein tyrosine phosphatases in ovarian granulosa cells. (2004)
  • Author(s): Mariko Tamura, Yoshimi Nakagawa, Hidehisa Shimizu, Noriaki Yamada, Takashi Miyano Hitoshi Miyazaki
  • Journal Title: Journal of Reproduction and Development 50・1 Pages: 47-55
  • NAID: 10026620927
• [Journal Article] Xenografting of bovine secondary follicles into ovariectomized Regulation mechanism of selective atresia in porcine follicles : regulation of granulosa cell apoptosis during atresia. (2004)
  • Author(s): Noboru Manabe, Yasufumi Goto, Fuko Matsuda-Minehata, Naoko Inoue, Akihisa Maeda, Miki Sugimoto, Kazuhiro Sakamaki, Takashi Miyano
  • Journal Title: Journal of Reproduction and Development 50・5 Pages: 493-514
• [Journal Article] Production of offspring from one-day-old oocytes stored at room temperature. (2004)
  • Author(s): Wakayama, S., Thuan, N.V., Kishigami, S., Ohta, H., Mizutani, E., Hikichi, T., Miyake, M., Wakayama, T.
  • Journal Title: Journal of Reproduction and Development 50・6 Pages: 627-637
  • NAID: 10027323645
• [Journal Article] The porcine (Sus scrofa) cellular Flice-like inhibitory protein (cFLIP) : molecular cloning and comparison with the human and murine cFLIP. (2004)
  • Author(s): Yasufumi Goto, Fuko Matsuda, Toshikatsu Matsui, Akihisa Maeda, Naoko Inoue, Noboru Manabe
  • Journal Title: Journal of Reproduction and Development 50・6 Pages: 549-555
  • NAID: 10027323381
• [Journal Article] Expression of epidermal growth factor receptor (EGF-R)-, vascular endothelial growth factor receptor (VEGF-R) and fibroblast growth factor receptor (FGF-R) systems in porcine oviduct and endometrium during the time of implantation. (2004)
  • Author(s): Karin Wollenhaupt, Harald Welter, Ralf Einspanier, Noboru Manabe, Klaus-Peter Brussow
  • Journal Title: Journal of Reproduction and Development 50・2 Pages: 269-278
  • NAID: 10027322327
• [Journal Article] differential transcriptional and translational regulations of calbindin-D9k by steroid hormones and their receptors in the uterus of immature mice. (2004)
  • Author(s): Beum-Soo An, Kyung-Chul Choi, Eui-Ju Hong, Yong-Woo Jung, Noboru Manabe, Eui-Bae Jeung
  • Journal Title: Journal of Reproduction and Development 50・4 Pages: 445-453
• [Journal Article] Full-term development of offspring using round spermatids produced ectopically from fetal male germ cells. (2004)
  • Author(s): Ohta, H., Wakayama, T.
  • Journal Title: Journal of Reproduction and Development 50・5 Pages: 429-437
  • NAID: 10027322895
• [Journal Article] Changes in the localization of type I, III and IV collagen mRNAs in the kidneys of hereditary nephritic (ICGN) mice with renal fibrosis. (2004)
  • Author(s): Kozue Uchio-Yamada, Noboru Manabe, Misuzu Yamaguchi-Yamada, Yasufumi Goto, Yoshie Yamamoto, Atsuo Ogura, Hajime Miyamoto
  • Journal Title: The Journal of Veterinary Medical Science 66・1 Pages: 123-128
  • NAID: 110003886367
• [Journal Article] Anemia with chromic renal disorder and disrupted metabolism of erythropoietin in ICR-derived glomerulonephritis (ICGN) mice. (2004)
  • Author(s): Misuzu Yamaguchi-Yamada, Noboru Manabe, Kozue Uchio-Yamada, Naotsugu Akashi, Yasufumi Gotoh, Youhei Miyamoto, Masaya Nagao, Yoshie Yamamoto, Atsuo Ogura, Hajime Miyamoto
  • Journal Title: The Journal of Veterinary Medical Science 66・3 Pages: 423-431
• [Journal Article] Improvement of anemia associated with chronic renal failure by recombinant human erythropoietin treatment in ICR-derived glomerulonephritis (ICGN) mice. (2004)
  • Author(s): Misuzu Yamaguchi-Yamada, Noboru Manabe, Yshufumi Goto, Sayuri Anann, Keiko Miyamoto, Youhei Miyamoto, Masaya Nagao, Yoshie Yamamoto, Atsuo Ogura
  • Journal Title: The Journal of Veterinary Medical Science 66・7 Pages: 883-886
  • NAID: 110003960155
• [Journal Article] Myofibroblastic differentiation in tubulointerstitial cells is provoked by augmented cytoplasmic Smad4 protein in hereditary nephrotic ICGN mice with chronic renal fibrosis. (2004)
  • Author(s): Ysufumi Goto, Noboru Manabe, Kozue Uchio, Misuzu Yamaguchi-Yamada, Naoko Inoue, Atsuo Ogura
  • Journal Title: Cell and Tissue Research 315・1 Pages: 209-221
• [Journal Article] Different molecular mechanisms underlie placental overgrowth phenotypes caused by interspecies hybridization, cloning, and Esx1 mutation. (2004)
  • Author(s): Singh, U., Fohn, L.E., Wakayama, T., Ohgane, J., Steinhoff, C., Lipkowitz, B., Schulz, R., Orth, A., Ropers, H.H., Behringer, R.R., Tanaka, S., Shiota, K., Yanagimachi, R., Nuber, U.A., Fundele, R.
  • Journal Title: Developmental Dynamics 230・1 Pages: 149-164
• [Journal Article] Skewed X-inactivation in cloned mice. (2004)
  • Author(s): Senda, S., Wakayama, T., Yamazaki, Y., Ohgane, J., Hattori, N., Tanaka, S., Yanagimachi, R., Shiota, K.
  • Journal Title: Biochemistry Biophysics Research Communication 321・1 Pages: 38-44
• [Journal Article] Regeneration of the infarcted heart with stem cells derived by nuclear transplantation. (2004)
  • Author(s): Lanza, R., Moore, M.A., Wakayama, T., Perry, A.C., Shieh, J.H., Hendrikx, J., Leri, A., Chimenti, S., Monsen, A., Nurzynska, D., West., M.D., Kajstura, J., Anversa, P.
  • Journal Title: Circlation Research 94・2 Pages: 820-827
• [Journal Article] The histone deacetylase inhibitor tricostatin A induces retrogressive chromatin decondensation in the germinal vesicle of fully grown porcine oocytes. (2004)
  • Author(s): Yuji Hirao, Naoki Takenouchi, Manabu Shimizu, Kosuke Iga, Takashi Miyano, Takashi Nagai
  • Journal Title: Journal of Mammalian Ova Research 21・3 Pages: 110-117
• [Journal Article] Activation and development of pig oocytes after microinjection of crude sperm extract. (2004)
  • Author(s): Konosuke Okada, Takashi Miyano, Masashi Miyake
  • Journal Title: Journal of Mammalian Ova Research 21・3 Pages: 134-140
  • NAID: 10014108967
• [Journal Article] Xenografting of bovine secondary follicles into male and female SCID mice. (2004)
  • Author(s): Shoichiro Senbon, Atsushi Ota, Masao Tachibana, Takashi Miyano
  • Journal Title: Journal of Mammalian Ova Research 21・3 Pages: 157-161
  • NAID: 10014109074
• [Journal Article] Regulation of endothelial cell death and its role in angiogenesis and vascular regression. (2004)
  • Author(s): Kazuhiro Sakamaki
  • Journal Title: Current Neurovascular Research 1・1 Pages: 305-315
• [Journal Article] Age-related thymic involution is mediated by Fas on thymic epithelial cells. (2004)
  • Author(s): Nobuyuki Yajima, Kazuhiro Sakamaki, Shin Yonehara
  • Journal Title: International Immunology 16・5 Pages: 1027-1035
  • NAID: 10013292015
• [Journal Article] The Sa113 locus is an epigenetic hotspot of aberrant DNA methylation associated with placentomegaly of cloned mice. (2004)
  • Author(s): Ohgane, J., wakayama, T., Senda, S., Yamazaki, Y., Inoue, K., Ogura, A., Marh, J., Tanaka, S., Yanagimachi, R.Shiota, K.
  • Journal Title: Genes Cells 9・1 Pages: 253-260
• [Book] Gamete Biology-Emerging Frontiers in Fertility and Contraceptive Development : Oocyte growth and acquisition of meiotic competence. (2006)
  • Author(s): Miyano T, Manabe N.
  • Total Pages: 312
  • Publisher: Nottinghm University Press
• [Book] Endocrine Disrupting Chemicals : Efect of various phtalates on the induction of Calbindin-D9k as an estrogen-like chemical in in vitro ans in vivo models. (2005)
  • Author(s): Eui-Ju Hong, Youn-Kyu Ji, Kyung-Chul Choi, Noboru Manabe, Eui-Bae Jeung
  • Total Pages: 482
  • Publisher: The Endocrine Society
• [Book] ウシの解剖・消化器系 (2005)
  • Author(s): 眞鍋 昇
  • Total Pages: 138
  • Publisher: チクサン出版株式会社
• [Book] 犬の繁殖(Dog Breeding) (2005)
  • Author(s): 眞鍋 昇, 佐籐英明, 永村武美
  • Total Pages: 338
  • Publisher: 株式会社インターズー
• [Book] 卵子形成・成熟および排卵の機能 : 生命の誕生に向けて (2005)
  • Author(s): 宮野 隆
  • Total Pages: 482
  • Publisher: 近代出版株式会社・日本哺乳動物卵子学会
• [Book] The Ovary (2nd edition) Chapter 21 : Follicle selection in mammalian ovaries : Regulatory mechanisms of granulosa cell apoptosis during follicular atresia.(Leung PCR, Adashi E eds)(pp 369-385) (2004)
  • Author(s): Noboru Manabe, Naoko Inoue, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto
  • Total Pages: 664
  • Publisher: Academic Press/Elsevier, New York, USA
• [Book] Abnormal accumulation of corpora lutes in ovaries of the senescence accelerated mouse prone (SAMP). The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence (Yasuyuki Nomura, Toshio Takeda, Yasunobu Okuma eds)(pp O79-785) (2004)
  • Author(s): Noboru Manabe, Minako Kiso, Munetake Shimabe, Nami Nakai-Sugimoto, Hajime Miyamoto
  • Total Pages: 448
  • Publisher: Elsevier Science Publishers B.V., Amsterdam, The Nederland
• [Book] Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP in ovaries of senescence accelerated mice. The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence (Yasuyuki Nomura, Toshio Takeda, Yasunobu Okuma eds)(pp 229-232) (2004)
  • Author(s): Munetake Shimabe, Minako Kiso, Kohji Komatsu, Noboru Manabe, Hajime Miyamoto
  • Total Pages: 448
  • Publisher: Elsevier Science Publishers B.V., Amsterdam, The Nederland
• [Book] Expression of prolactin receptor mRNA in ovaries of senescence accelerated mice. The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence (Yasuyuki Nomura, Toshio Takeda, Yasunobu Okuma eds)(pp 233-236) (2004)
  • Author(s): Minako Kiso, Munetake Shimabe, Kohji Komatsu, Noboru Manabe, Hajime Miyamoto
  • Total Pages: 448
  • Publisher: Elsevier Science Publishers B.Y., Amsterdam, The Nederland
• [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Hajime Miyamoto: "Changes in the expression of tumor necrosis factor (TNF)a, TNFa Receptor (TNFR) 2 and TNFR-associated factor 2 in granulosa cells during atresia in pig ovaries."Biology of Reproduction. 68(2). 530-535 (2003)
• [Publications] Kohji Komatsu, Noboru Manabe, Minako Kiso, Munetake Shimabe, Hajime Miyamoto: "Changes in localization of immune cells and cytokines in corpora lutea during luteolysis in murine ovaries."Journal of Experimental Zoology. 296(1). 152-159 (2003)
• [Publications] Kohji Komatsu, Noboru Manabe, Minako Kiso, Munetake Shimabe, Hajime Miyamoto: "Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries."Molecular Reproduction and Development. 65. 345-352 (2003)
• [Publications] Toshikatsu Matsui, Noboru Manabe, Yasufumi Goto, Mizuho Nakayama, Naoko Inoue, Susumu Nishihara, Hajime Miyamoto: "Changes in the expression and activity of caspase-9 and Apafl in granulosa cells during follicular atresia in pig ovaries."Reproduction. 126. 113-120 (2003)
• [Publications] Istvan Egerszegi, Falk Schneider, Jozsef Ratky, Ferenc Soos, Laszlo Solti, Noboru Manabe, Klaus-Peter Brussow: "Comparison of luteinizing hormone and steroid hormone secretion during the peri-and post-ovulatory periods in mangalica and landrace gilts."Journal of Reproduction and Development. 49(4). 291-296 (2003)
• [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Akihisa Maeda, Shynsuke Nakagawa, Satoko Wada, Hajime Miyamoto: "roles of tumor necrosis factor-related apoptosis-inducing ligand signaling pathway in granulosa cell apoptosis during atresia in pig ovaries."Journal of Reproduction and Devevelopment. 49(4). 313-321 (2003)
• [Publications] Satoshi Imanishi, Noboru Manabe, Hanako Nishizawa, Maki Morita, Miki Sugimoto, Mineko Iwahori, Hajime Miyamoto: "Effects of oral exposure of bisphenol A on mRNA expression of nuclear receptors in murine placentae assessed by DNA microarray."Journal of Reproduction and Devevelopment. 49(4). 329-336 (2003)
• [Publications] Minako Kiso, Noboru Manabe, Kohji Komatsu, Munetake Shimabe, Hajime Miyamoto: "Abnormal structural luteolysis in ovaries of the senescence accelerated mouse (SAM) : expression of Fas Ligand/Fas-mediated apoptosis signaling molecules in luteal cells."Journal of Reproduction and Devevelopment. 49(6). 457-463 (2003)
• [Publications] Hanako Nishizawa, Noboru Manabe, Maki Morita, Miki Sugimoto, Satoshi Imanishi, Hajime Miyamoto: "Effects of in utero exposure of bisphenol A on expression of RARα and RXRα mRNAs in murine embryos."Journal of Reproduction and Devevelopment. 49(6). 539-545 (2003)
• [Publications] Kozue Uchio-Yamada, Noboru Manabe, Misuzu Yamaguchi-Yamada, Yasufumi Goto, Yoshie Yamamoto, Atsuo Ogura, Hajime Miyamoto: "Changes in the localization of type I, III and IV collagen mRNAs in the kidneys of hereditary nephritic (ICGN) mice with renal fibrosis."The Journal of Veterinary Medical Science. 66(2). 123-128 (2004)
• [Publications] Miki Sugimoto, Noboru Manabe, Maki Morita, Kei-Ichi Sezaki, Takako Tanaka, Satoshi Imanishi, Hanako Nishizawa, Mineko Iwahori, Hajime Miyamoto: "NMR spectroscopic assessment of effects of estrogenic compounds on male reproductive organs in mice."Biology of Reproduction. 67. 186 (2003)
• [Publications] Ysufumi Goto, Noboru Manabe, Kozue Uchio, Misuzu Yamaguchi-Yamada, Naoko Inoue, Yoshie Yamamoto, Atsuo Ogura, Nobuo Nagano, Hajime Miyamoto: "Myofibroblastic differentiation in tubulointerstitial cells is provoked by augmented cytoplasmic Smad4 protein in hereditary nephrotic ICGN mice with chronic renal fibrosis."Cell and Tissue Research. 315. 209-221 (2004)
• [Publications] Miki Sugimoto, Noboru Manabe, Hajime Miyamoto: "Cryopreservation of ovarian tissue."Igakuno Ayumi. 204(13). 921-925 (2003)
• [Publications] Noboru Manabe, Naoko Inoue, Chiemi Tajima, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Monoclonal antibodis recognize novel cell death receptors of granulosa cells in pig ovaries."Biology of Reproduction. 67. 234 (2003)
• [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Changes in expression of fas-dependent apoptotic signaling molecules in granulosa cells during folliclar atresia in pig ovaries."Biology of Reproduction. 67. 234 (2003)
• [Publications] Satoshi Imanishi, Noboru Manabe, Miki Sugimoto, Hajime Miyamoto: "Changes in mRNA expression of GPRC5B/RAIG2, a novel orphan receptor, in mouse placenta during late gestation."Biology of Reproduction. 67. 154 (2003)
• [Publications] Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Noboru Manabe, Satoko Wada, Naoko Inoue, Toshikatu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Shinsuke Nakagawa, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Miki Sugimoto, Noboru Manabe, Maki Morita, Satoshi Imanishi, Hanako Nishizawa, Mineko Iwahori, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Noboru Manabe, Yasuyoshi Azuma, Miki Sugimoto, Satoshi Imanishi, Hanako Nishizawa, Maki Morita, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Noboru Manabe, Naoko Inoue, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto: "The Ovary, 2^<nd> edition"Academic Press/Elsevier Science, Amsterdam, The Nederland. 664 (2003)
• [Publications] Noboru Manabe: "Veterinary Histology 3^<rd> edition"Gakusoshya Pub.Co, Tokyo, Japan. 315 (2003)
• [Publications] Noboru Manabe: "Biology of Reproduction 2^<nd> edition"Asakura Pub.Co, Tokyo, Japan. 315 (2003)
• [Publications] Noboru Manabe, Minako Kiso, Munetake Shimabe, Hajime Miyamoto: "The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence"Elsevier Science Publishers B.V., Amsterdam, The Nederland. 448 (2004)
• [Publications] Toshikatu Matsui, Noboru Manabe, Yasufumi Goto, Naoko Inoue, Shinsuke Nakagawa, Akihisa Maeda, Susumu Nishihara, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Misuzu Yamaguchi-Yamada, Noboru Manabe, Kozue Uchio-Yamada, Naotsugu Akashi, Yasufumi Gotoh, Masaya Nagao, Yoshie Yamamoto, Atsuo Ogura, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Minako Kiso, Noboru Manabe, Kohji Komatsu, Munetake Shimabe, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Noboru Manabe, Kozue Yamada-Uchio, Misuzu Yamada-Yamaguchi, Yasufumi Gotoh, Toshiharu Mori, Chinatsu Sakata, Yoshihiro Furuya, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Maki Morita, Miki Sugimoto, Takako Tanaka, Satoshi Imanishi, Hanako Nishizawa, Kei-Ichi Sezaki, Mineko Iwahori, Noboru Manabe, Hajime Miyamoto: "Animal Frontier Science"Hokuto Pub.Co, Kyoto. 363 (2003)
• [Publications] Munetake Shimabe, Minako Kiso, Kohji Komatsu, Noboru Manabe, Hajime Miyamoto: "The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence"Elsevier Science Publishers B.V., Amsterdam, The Nederland. 448 (2004)
• [Publications] Minako Kiso, Munetake Shimabe, Kohji Komatsu, Noboru Manabe, Hajime Miyamoto: "The Senescence-Accelerated Mouse (SAM) : An Animal Model of Senescence"Elsevier Science Publishers B.V., Amsterdam, The Nederland. 448 (2004)
• [Publications] Morikawa Masahiro, Wakoto Matsuyama, Miki Sugimoto, Maki Morita, Aki Nakayama, Noboru Manabe, Shinsuke Morisawa: "Environmental Toxicity Evaluation and Risk Management"The Environment Risk Management Group of the JSPS-VCC Program on Environmental Science, Engineering and Ethics 2000-2009. Kyoto, Japan. 159 (2003)
• [Publications] Noboru Manabe, Minako Kiso, Munetake Shimabe, H.Miyamoto: "Proceedings of the 2^<nd> International Conference on Senescence : The SAM model"The Council for SAM Research, Sapporo, Japan. 120 (2003)
• [Publications] Munetake Shimabe, Minako Kiso, Noboru Manabe, Hajime Miyamoto: "Proceedings of the 2^<nd> International Conference on Senescence : The SAM model"The Council for SAM Research, Sapporo, Japan. 120 (2003)
• [Publications] Minako Kiso, Munetake Shimabe, Noboru Manabe, Hajime Miyamoto: "Proceedings of the 2^<nd> International Conference on Senescence : The SAM model"The Council for SAM Research, Sapporo, Japan. 120 (2003)
• [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Hajime Miyamoto: "Changes in the expression of tumor necrosis factor (TNF)a, TNFa Receptor (TNFR) 2 and TNFR-associated factor2 in granulosa cells during atresia in pig ovaries"Biology of Reproduction. 68・2. 530-535 (2003)
• [Publications] Uchio K, Tuchweber B, Manabe Noboru, Gabbiani G, Rosenbaum J, Desmouliere A.: "Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts"Laboratory Investigation. 82・4. 619-628 (2002)
• [Publications] Chiemi Tajima, Noboru Manabe, Mizuho Nakayama, Naoko Inoue, Toshikatsu Matsui, Eiichi Hondo, Hajime Miyamoto: "Monoclonal antibody recognizes follicular granulosa cell antigens in porcine ovaries"Journal of Reproduction and Devevelopment. 48・4. 567-572 (2002)
• [Publications] Satoshi Imanishi, Noboru Manabe, Takako Tanaka, Reika Okamoto, Maki Morita, Miki Sugimoto, Hajime Miyamoto: "mRNA of GPCR5B/Raig2, a novel orphan receptor, expresses in murine placentae"Journal of Reproduction and Devevelopment. 48・4. 627-632 (2002)
• [Publications] Noboru Manabe: "Molecular mechanism of follicle selection in mammalian ovaries"Journal of Laboratory Animals (Kansai). 23・1. 71-78 (2002)
• [Publications] Noboru Manabe, Miki Sugimoto, Hajime Miyamoto: "In vivo noninvasive nuclear magnetic resonance (NMR) technique for assessment of teratogenicity induced by chemicals"Chemical Engineering. 47・2. 110-114 (2002)
• [Publications] Satoko Wada, Noboru Manabe, Naoko Inoue, Mizuho Nakayama, Toshikatsu Matsui, Hajime Miyamoto: "TRAIL-decoy receptor-1 disappears in granulosa cells of atretic follicles in porcine ovaries"Journal of Reproduction and Devevelopment. 48・1. 167-173 (2002)
• [Publications] Satoko Wada, Noboru Manabe, Naoko Inoue, Mizuho Nakayaina, Toshikatsu Matsui, Hajime Miyamoto: "TRADD is involved in apoptosis induction in granulosa cells during atresia in pig ovaries"Journal of Reproduction and Devevelopment. 48・1. 175-181 (2002)
• [Publications] Hideki Tonomura H, Miyake T, Taniguchi Y, Manabe Noboru, Kose H, Matsumoto K, Yamada T, Sasaki Y.: "Detection of quantitative trait locus for rat model useful for genetic analysis of intramascular fat accumulation using the OLETF rat"The Journal of Veterinary Medical Science. 64・1. 45-50 (2002)
• [Publications] Satoko Wada, Noboru Manabe, Mizuho Nakayama, Naoko Inoue, Toshikatsu Matsui, Hajime Miyamoto: "TRAIL-decoy receptor-1 plays inhibitory role in apoptosis of granulosa cells from pig ovarian follicules"The Journal of Veterinary Medical Science. 64・5. 435-439 (2002)
• [Publications] Miki Sugimoto, Noboru Manabe, Maki Morita, Takako Tanaka, Reika Okamoto, Satoshi Imanishi, Hajime Miyamoto: "NMR microscopic observation of mouse embryo malformations induced by maternal administration of retinoic acid"The Journal of Veterinary Medical Science. 64・5. 427-433 (2002)
• [Publications] Miki Sugimoto, Noboru Manabe, Hajime Miyamoto: "Cryopreservation techniques for ovarian tissues"Hormone Frontier in Gynecology. 9・1. 135-140 (2002)
• [Publications] Noboru Manabe, Naoko Lnoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Regulatory mechanisms of follicle selection in mammalian ovaries. PP. 117-132"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Tumor necrosis factor-related apoptosis-inducing ligand and its receptors play crucial roles in apoptosis of granulosa cells during follicular atresia in pig ovaries. PP. 133-142"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Mizuho Nakayama, Noboru Manabe, Naoko Inoue, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto Sakamaki, Miki Sugimoto, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Tumor necrosis factor-α acts as a survival factor in granulosa cells during follicular selection in porcine ovaries. PP. 143-149"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Naoko Inoue, Noboru Manabe, Toshikatsu Matsui, Shinsuke Nakagawa, Akihisa Maeda, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Roles of Fas-ligand and TRAIL systems in granulosa cell apoptosis during follicular atresia in porcine ovaries. PP. 151-156"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Toshikatu Matsui, Noboru Manabe, Yasufumi Goto, Naoko Inoue, Shinsuke Nakagawa, Akihisa Maeda, Susumu Nishihara, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Role of the mitochondria-dependent pathway in granulosa cell apoptosis during follicular atresia in pig ovaries. PP. 157-163"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Yamaguchi-Yamada M, Noboru Manabe, Uchio-Yamada K, Akashi N, Gotoh Y, Nagao M, Yamamoto Y, Ogura A, Miyamoto H.: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Anemia associated with renal failure in the ICR-derived glomerulonephritis (ICGN) mice. PP. 281-285"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Minako Kiso, Noboru Manabe, Kohji Komatsu, Munetake Shimabe, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Abnormal structural luteolysis in ovaries of the senescence accelerated mouse (SAM) : expression of Fas mediated apoptosis signal in luteal bodies. PP. 287-294"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Noboru Manabe, Kozue Yamada-Uchio, Misuzu Yamada-Yamaguchi, Yasufumi Gotoh, Toshiharu Mori, Chinatsu Sakata, Yoshihiro Furuya, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Histochemical technique quantitatively estimates the physiological and pathological properties. PP. 303-309"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Maki Morita, Miki Sugimoto, Noboru Manabe, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Morphological alterations in mammalian reproductive organ induced by exposure to diethylstilbestrol (DES). PP. 319-323"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Miki SUGIMOTO, Noboru MANABE, Maki MORITA, Hajime MIYAMOTO: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), Utilization of magnetic resonance microscope for studies in reproductive toxicology. PP. 325-330"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Noboru Manabe, Yasuyoshi Azuma, Miki Sugimoto, Kei-Ichi Sezaki, Mineko Iwahori, Satoshi Imanishi, Hanako Nishizawa, Takako Tanaka, Maki Morita, Hajime Miyamoto: "Animal Frontier Science (Sato E, Miyamoto H, Manabe Noboru eds.), In vivo and real time estimation of energy metabolism by ^<31>p-nuclear magnetic resonance. PP. 339-347"Hokuto Publication Company, Kyoto, Japan. 363 (2003)
• [Publications] Morikawa Masahiro, Wakoto Matsuyama, Yuko Kawamoto, Miki Sugimoto, Maki Morita, Aki Nakayama, Noboru Manabe, Minoru Yoneda, Shinsuke Morisawa: "Environmental Toxicity Evaluation and Risk Management Vol. 1 (Morisawa S eds.), Dynamic performance of bisphenol-A (BPA) in pregnant mouse and physiologically-based pharmacokinetic model development. PP. 60-74"The Environment Risk Management Group of The JSPS-VCC Program on Environmental Science, Engineering and Ethics 2000-2009. Kyoto, Japan. 159 (2002)
• [Publications] Satoko Wada, Noboru Manabe et al.: "TRAIL-decoy receptor-1 disappears in granulosa cells of atretic follicles in porcine ovaries"Journal of Reproduction and Devevelopment. 48・2. 167-173 (2002)
• [Publications] Satoko Wada, Noboru Manabe et al.: "TRADD is involved in apoptosis induction in granulosa cells during atresia in pig ovaries"Journal of Reproduction and Devevelopment. 48・2. 175-181 (2002)
• [Publications] Hitoshi Okamura, Noboru Manabe et al.: "Protein tyrosine kinase expression in the porcine ovary"Molecular Human Reproduction. 7・6. 723-729 (2001)
• [Publications] Eiichi Hondo, Noboru Manabe et al.: "Molecular cloning and expression of suppressor of potassium transport defect 3 (SKD3) in rat testis"Journal of Reproduction and Devevelopment. 47・2. 173-180 (2001)
• [Publications] Minako Kiso, Noboru Manabe et al.: "Abnormal accumulation of luteal bodies in ovaries of the senescence accelerated mouse (SAM)"Journal of Reproduction and Devevelopment. 47・2. 153-164 (2001)
• [Publications] Mizuho Nakayama, Noboru Manabe et al.: "Changes in localization of type I, III and IV collagens and their mRNA expression during follicular atresia in bovine and porcine ovaries"Journal of Reproduction and Devevelopment. 47・1. 27-31 (2001)
• [Publications] Noboru Manabe et al.: "A novel in vivo NMR technique to assess halocarbon induced hepatic failure in mice"Water Science and Technology. 17・1. 32-38 (2001)
• [Publications] Noboru Manabe et al.: "In vivo noninvasive nuclear magnetic resonance (NMR) technique for assessment of teratogenicity induced by chemicals"Chemical Engineering. 47・1. 110-114 (2002)
• [Publications] Miki Sugimoto, Noboru Manabe et al.: "Update on cryopreservation of mammalian ovaries"Obstetrics and Gynecology. 68・2. 207-212 (2001)
• [Publications] Noboru Manabe et al.: "A novel cell death receptor and a decoy receptor on follicular granulose cells of porcine ovaries"Japanese Journal of Embryo Transfer. 23・1. 52-60 (2001)
• [Publications] Naoko Inoue, Noboru Manabe et al.: "Elongation of cell cycle of early stage tetraploid murine embryos induced by cytochalasin B"Japanese Journal of Embryo Transfer. 23・1. 44-51 (2001)
• [Publications] Noboru Manabe et al.: "Physiological roles of apoptosis in granulosa cells of atretic follicles in porcine ovaries"Japanese Journal of Embryo Transfer. 23・1. 1-10 (2001)
• [Publications] Noboru Manabe et al.: "Monoclonal antibodies recognize a novel cell death receptor and a decoy receptor on granulosa cells of porcine ovarian follicles"Journal of Mammalian Ova Research. 18・1. 1-13 (2001)
• [Publications] Noboru Manabe et al.: "Immunohistochemical Quantification of fast-myosin in upper hind limp muscles of the pig"Animal Science Journal. 72・2. 154-163 (2001)
• [Publications] Hideki Tonomura, Nobor Manabe et al.: "Detection of rat model useful for genetic analysis of intramascular fat accumulation"Animal Genetic Journal. 2・1. 3-10 (2001)
• [Publications] Brussow K-P, Noboru Manabe et al.: "Biotechnological aspects of embryo transfer in swine"Hungarian Animal Breeding and Nutrition. 50・4. 481-493 (2001)
• [Publications] Noboru Manabe et al.: "Changes in quantitative profile of extracellular matrix components in the kidneys of rats with adriamycin-induced nephropathy"Journal of Veterinary Medical Science. 61・1. 125-133 (2001)
• [Publications] Misuzu Yamaguchi, Noboru Manabe et al.: "Localization of proliferative and apoptptic cells in the kidneys of ICR-derives glomerulonephritis (ICGN) mice"Journal of Veterinary Medical Science. 62・6. 781-787 (2001)
• [Publications] Kozue Uchio-Yamada, Noboru Manabe et al.: "Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome"Journal of Veterinary Medical Science. 62・11. 1171-1178 (2002)
• [Publications] Malki Morita, Noboru Manabe et al.: "Changes in morphology of mouse oviduct ampulla during early pregnancy"Biology of Reproduction. 64・2. 325 (2001)
• [Publications] Noboru Manabe et al.: "Teratosis induced by retinoites to apoptotic cell death in mouse embryos"Miyamoto H, Manabe N (eds), Reproductive biotechnology update and its related physiology Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)
• [Publications] Takako Tanaka, Noboru Manabet al.: "Effects of endocrine disruptersrts on the expression of nuclear receptors in murine embryos"Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Miki Sugimoto, Noboru Manabe et al.: "Uilization of NMR microscopy in developmental toxicology : assessment of mouse embryo malformations induced by maternal administration of retinoic acid"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Noboru Manabe et al.: "Quantitative estimation of physiological properties by histochemical techniques"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Noboru Manabe et al.: "In vivo 31P-nuclear magnetic resonance technique for estibation of liver energy metabolism in mice"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Miki SUGIMOTO, Noboru Manabe et al.: "Histological and biochemical profiles of granulosa cell apoptosis in follicular atresia of porcine ovaries"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Noboru Manabe et al.: "Cell death receptor dependent regulation of granulosa cell apoptosis in porcine ovarian follicle atresia"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Mizuho Nakayama, Noboru Manabe et al.: "Histochemical studies for comparison of regulatory mechanisms of follicular development in mammmalian ovaries"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Namiko Kiso, Noboru Manabe et al.: "Abnormal accumulation of luteal bodies in ovaries of the senescence accelerated mouse(SAM)"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Maki Morita, Noboru Manabe et al.: "Functions of mammalian oviducts and their relevance to morphology"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Kozue Yamada-Uchio, Noboru Manabe et al.: "Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Misuzu Yamaguchi, Noboru Manabe et al.: "Renal anemia in ICR-derived glomerulonephritis (ICGN) mice"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] Miki Sugimoto, Noboru Manabe et al.: "Cryopreservation of mammalian ovarian tissue"Miyamoto H, Manabe N(eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology(Hokuto Publishing Co., (Kyoto, Japan)). 424 (2001)
• [Publications] 眞鍋昇: "雌性生殖器官"獣医組織学 第2版,日本獣医解剖学会編集(学窓社.東京.). 448 (2001)