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中空マイクロカプセルの製造および超音波造影剤と薬物伝達システムへの応用

Research Project

Project/Area Number 13J06917
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Thermal engineering
Research InstitutionThe University of Tokyo

Principal Investigator

MOLINO CornejoJayJesus (2014)  東京大学, 工学系研究科, 特別研究員(PD)

MOLINO CornejoJa (2013)  東京大学, 大学院工学系研究科, 特別研究員(DC2)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2014: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2013: ¥900,000 (Direct Cost: ¥900,000)
KeywordsHenry’s law constant / Organic solvents / Polymer concentration / Dissolution / Adsorption / Thermodynamics / Bubble dynamics / Surface chemistry / Solubility of gases / Bubble nucleation / Encapsulation
Outline of Annual Research Achievements

In the studies performed before April 2014, we discovered that changing the concentration of poly lactic acid (PLA) in a solution of PLA in dichloromethane yield to a change in the Henry’s law constant for nitrogen. This is crucial because if the solubility of gases in polymer solvents is an important consideration in removing volatile gases from the polymers, we have one more parameter available for designing microcellular/foam or for fabricating biodegradable hollow microcapsules and porous films, which is the final objective of our study.
In the studies performed after April 2014, the effect of dissolved PLA on the solubility of gases (carbon dioxide, nitrogen, and helium) in dichloromethane was investigated, between 288 and 303 K, by measuring the equilibrium pressure in a closed vessel containing a gas and dichloromethane solutions of different types (molecular weights) and concentrations of PLA. The results showed that, in the absence of PLA, the order of the solubility of gases in dichloromethane was helium < nitrogen < carbon dioxide. Furthermore, an increase in the concentration of PLA did not appreciably change the solubility of carbon dioxide in the solutions, but led to a higher solubility of nitrogen and He. The effect of PLA on the increase of gas solubility in dichloromethane was larger for less soluble gases. Semi-empirical correlations of the dependence of the Henry’s law constant of the gases on the temperature and PLA concentration were also derived from the measured data.

Research Progress Status

26年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

26年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (4 results)

All 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Hollow polylactic acid microcapsules fabricated by gas/oil/water and bubble template methods2013

    • Author(s)
      Daichi Sakurai, Jay Jesus Molino, Hirofumi DaiguJi and Fumio Takemura
    • Journal Title

      Journal of Materials Chemistry A

      Volume: 1 Issue: 46 Pages: 14562-14568

    • DOI

      10.1039/c3ta12587d

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ポリマー発泡溶液を用いた中空マイクロカプセルの製造2015

    • Author(s)
      櫻井 大地,モリノ ジェイ,大宮司 啓文,竹村 文男
    • Organizer
      第 52回日本伝熱シンポジ ウム
    • Place of Presentation
      福岡国際会議場、福岡市
    • Year and Date
      2015-06-03 – 2015-06-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of Polylactic Acid Concentration on the Solubility of Gases in Dichloromethane2014

    • Author(s)
      Jay Jesus Molino, Daichi Sakurai, Hirofumi Daiguji, and Fumio Takemura
    • Organizer
      第 51 回日本伝熱シンポジ ウム
    • Place of Presentation
      アクトシティ浜松・コングレスセンター、浜松市
    • Year and Date
      2014-05-21 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Remarks]

    • URL

      http://www.thml.t.u-tokyo.ac.jp/en/publications.html

    • Related Report
      2013 Annual Research Report

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Published: 2014-01-29   Modified: 2024-03-26  

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