• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

幹細胞の可塑性と未分化性維持機構

Research Project

Project/Area Number 14081101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

中内 啓光  The University of Tokyo, 医科学研究所, 教授 (40175485)

Co-Investigator(Kenkyū-buntansha) 丹羽 仁史  理化学研究所, 多能性幹細胞研究, チームリーダー(研究職) (80253730)
横田 崇  金沢大学, 医学系研究科, 教授 (50134622)
須田 年生  熊本大学, 発生医学研究センター, 教授 (60118453)
岡野 栄之  慶応義塾大学, 医学部, 教授 (60160694)
石川 冬木  東京工業大学, 生命理工学研究科, 教授 (30184493)
Project Period (FY) 2002 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥31,400,000 (Direct Cost: ¥31,400,000)
Fiscal Year 2007: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2005: ¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2004: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2003: ¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 2002: ¥3,900,000 (Direct Cost: ¥3,900,000)
Keywords幹細胞 / 未分化性維持機構 / 再生医療 / テクノロジー / 未分化性 / 可塑性 / 自己複製 / 多分化能 / 造血幹細胞 / ニッシェ / ホーミング / ES細胞 / ATM / ポリコーム遺伝子産物 / 造的幹細胞 / 末分化性維持機構
Research Abstract

本特定領域研究では1)細胞の初期化の機構の解明、2)幹細胞の未分化性維持機構、3)幹細胞の多様性と可塑性の三つの柱を中心に5年間にわたり研究を進めた。ES細胞、組織幹細胞のそれぞれにおいて研究が大きく進展したが、最近2年間に本特定領域研究の分担研究者である山中伸弥教授らによって遺伝子導入によって体細胞を多能性幹細胞に変換する技術が開発され、再生医療・幹細胞研究に大きな転換を迎える事態となったことは特筆すべきことである。厳しいガイドラインのため本邦においてはヒトES細胞研究が諸外国と比して進展に遅れていたが、倫理的問題を含まないiPS細胞技術の登場により、多能性幹細胞の分野にも今後大きな研究の進展が見込まれる。そこで昨年度は新しく開発されたiPS細胞産生技術を中心に「幹細胞研究を支える新しいテクノロジー」というテーマのもとでシンポジウムを開催した。産業界を含む300名近い研究者が参加し意見を交換することにより、本研究領域における研究で得られた知見を速やかに共有することができた。また、総括班メンバーを中心に今後の幹細胞研究の進め方などについても討議がなされた。

Report

(5 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (129 results)

All 2008 2007 2006 2005 2004 Other

All Journal Article (117 results) (of which Peer Reviewed: 21 results) Book (1 results) Publications (11 results)

  • [Journal Article] Interleukin-27 directly induces differentiation in hematopoietic stem cells.2008

    • Author(s)
      Seita J, et. al.
    • Journal Title

      Blood. 111

      Pages: 1903-12

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The WAVE2/Abil complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.2007

    • Author(s)
      Eto K, et. al.
    • Journal Title

      Blood. 110

      Pages: 3639-47

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007

    • Author(s)
      Chiba T, et. al.
    • Journal Title

      Gastroenterology. 133

      Pages: 937-50

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool.2007

    • Author(s)
      Miyamoto K, et. al.
    • Journal Title

      Cell Stem Cell. 1

      Pages: 101-12

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The plasminogen fibrinolytic pathway is required for hematopoietic regeneration.2007

    • Author(s)
      Heeissig B, et. al.
    • Journal Title

      Cell Stem Cell. 1

      Pages: 658-70

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cdlcnla deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.2007

    • Author(s)
      Choudhury, A. R., et. al.
    • Journal Title

      Nat Genet. 39

      Pages: 99-105

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.2007

    • Author(s)
      Tadokoro, Y, et. al.
    • Journal Title

      J Exp Med. 204

      Pages: 715-22

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of GATA-1^+ hemangioblastic cells in the mouse embryo.2007

    • Author(s)
      Yokomizo T, et. al.
    • Journal Title

      EMBO J. 26

      Pages: 184-196

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development.2007

    • Author(s)
      Suzuki A, et. al.
    • Journal Title

      Development. 134

      Pages: 77-83

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ES cell culture as a tool for developmental cell biology.2007

    • Author(s)
      Nishikawa S-I, et. al.
    • Journal Title

      Nature Rev Mol Cell Biol. 8

      Pages: 502-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroepithelial cells supply an initial transient wave of MSC differentiation.2007

    • Author(s)
      Takashima Y, et. al.
    • Journal Title

      Cell. 129

      Pages: 1377-88

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of long-term repopulating potential of human cordblood-derived CD34^-flt3^- severe combined immunodeficiency-repopulating cells by intra-bone marrow injection.2007

    • Author(s)
      Kimura T, et. al.
    • Journal Title

      Stem Cells. 25

      Pages: 1348-55

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene and cell therapy for relapsed leukemia after allo-stem cell transplantation.2007

    • Author(s)
      Onodera M, et. al.
    • Journal Title

      Gene Therapy.

      Pages: 286-94

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reciprocal targeting of Hath1 and β-catenin by Wnt-glycogen synthase kinase 3β in human colon cancer.2007

    • Author(s)
      Tsuchiya K, et. al.
    • Journal Title

      Gastroenterology. 132

      Pages: 208-20

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial bottleneck occurs without reduction of mtDNA content in mouse female germ cells.2007

    • Author(s)
      Cao L, et. al.
    • Journal Title

      Nat. Genet. 39

      Pages: 386-90

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful reconstruction of human endometrium from singly dispersed endometrial cells in the severe immunodeficient mouse: its potenital application as endometriosis model.2007

    • Author(s)
      Masuda H, et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 104

      Pages: 1925-30

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate andbehave like transient amplifying cells.2007

    • Author(s)
      Yamada Y, et. al.
    • Journal Title

      Exp Cell Res. 313

      Pages: 698-706

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Significant Cardiomyogenic Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Vitro.2007

    • Author(s)
      Nishiyama N, et. al.
    • Journal Title

      Stem Cells.

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 'Working' cardimyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells.2007

    • Author(s)
      Okamoto K, et. al.
    • Journal Title

      Exp Cell Res. 313

      Pages: 2550-63

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting.2007

    • Author(s)
      Oshima Y, et. al.
    • Journal Title

      Gastroenterology. 132

      Pages: 720-32

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells2007

    • Author(s)
      Tadokoro Y, et al.
    • Journal Title

      J Exp Med. 204

      Pages: 715-722

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.2007

    • Author(s)
      Kato Y, et al.
    • Journal Title

      Int J Hematol. 85

      Pages: 179-181

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.2007

    • Author(s)
      Seita, J, et al.
    • Journal Title

      Proc Natl Acad Sci USA 104

      Pages: 2349-2354

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Stable Transgene Expression in Mice Generated from Retrovirally Transduced Embryonic Stem Cells.2007

    • Author(s)
      Hamanaka S, et al.
    • Journal Title

      Mol Ther. 15

      Pages: 560-565

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bmil cooperates with Dnmtl-assciated protein 1 in gene silencing.2007

    • Author(s)
      Negishi M, et al.
    • Journal Title

      Biochem Biophys Res Commun. 353

      Pages: 992-998

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A. Regulation of reactive oxygen species by atm is essential for proper response to DNA double-strand breaks in lymphocytes.2007

    • Author(s)
      Ito K, et al.
    • Journal Title

      J Immunol 178

      Pages: 103-110

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.2007

    • Author(s)
      Zaugg K, et al.
    • Journal Title

      Proc Natl Acad Sci U S A. 104

      Pages: 3805-3810

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Foxo3a is essential for maintenance of the hematopoietic stem cell pool.2007

    • Author(s)
      Miyamoto K
    • Journal Title

      Cell Stem Cell (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Activin/Nodal signaling is involved in propagation of mouse embryonic stem cells.2007

    • Author(s)
      Ogawa K, et al.
    • Journal Title

      J Cell Sci. 120

      Pages: 55-65

    • Related Report
      2006 Annual Research Report
  • [Journal Article] How is pluripotency determined and maintained?2007

    • Author(s)
      Niwa H.
    • Journal Title

      Development. 134

      Pages: 635-646

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Proxl induces lymphatic endothelial differentiation via Integrin a9 and other signaling cascades.2007

    • Author(s)
      Mishima K, et al.
    • Journal Title

      Mol Biol Cell. 18

      Pages: 1421-1429

    • Related Report
      2006 Annual Research Report
  • [Journal Article] B cell potential can be obtained from pre-circulatory yolk sac, but with low frequency.2007

    • Author(s)
      Sugiyama D, et al.
    • Journal Title

      Dev. Biol. 301

      Pages: 53-61

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization of GATA-1^+ hemangioblastic cells in the mouse embryo.2007

    • Author(s)
      Yokomizo T, et al.
    • Journal Title

      EMBO J 26

      Pages: 184-196

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells.2006

    • Author(s)
      Yamazaki S, et al.
    • Journal Title

      EMBO J 25

      Pages: 3515-3523

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Non-side-population hematopoietic stem cells in mouse bone marrow.2006

    • Author(s)
      Morita Y, et al.
    • Journal Title

      Blood 108

      Pages: 2850-2856

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Therapy with Dendritic Cells Genetically Modified by the Gene-Silencing-Resistant Retroviral Vector GCDNsap.2006

    • Author(s)
      Nabekura T, et al.
    • Journal Title

      Mol Ther 13

      Pages: 301-309

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Discordant developmental waves of angioblasts and hemangioblasts in the early gastrulating mouse embryo.2006

    • Author(s)
      Furuta C, et al.
    • Journal Title

      Development 133

      Pages: 2771-2779

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A role for PKCq in outside-in aIIbb3 signaling.2006

    • Author(s)
      Soriani A, et al.
    • Journal Title

      J Thromb Haemost. 4

      Pages: 648-655

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Integrin aIIbb3 induces the adhesion and activaton of mast cells through interaction with fibrinogen.2006

    • Author(s)
      Oki T, et al.
    • Journal Title

      J Immunol 176

      Pages: 52-60

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetic marking of hematopoietic stem and endothelial cells : identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain.2006

    • Author(s)
      Takayanagi S-I, et al.
    • Journal Title

      Blood 107

      Pages: 4317-4325

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification and differentiation of hepatic stem cells during liver development.2006

    • Author(s)
      Kamiya A, et al.
    • Journal Title

      Front Biosci 11

      Pages: 1302-1310

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cdknla deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.2006

    • Author(s)
      Choudhury AR, et al.
    • Journal Title

      Nature Genet. 39

      Pages: 99-105

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmil-deficient mice.2006

    • Author(s)
      Oguro H, et al.
    • Journal Title

      J Exp Med 203

      Pages: 2247-2253

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.2006

    • Author(s)
      Sakaguchi T, et al.
    • Journal Title

      Mol Cell Biol. 26

      Pages: 6557-6570

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.2006

    • Author(s)
      Chiba T, et al.
    • Journal Title

      Hepatology. 44

      Pages: 240-251

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon.2006

    • Author(s)
      Miyagi S, et al.
    • Journal Title

      J. Biol. Chem et al. 19

      Pages: 13374-13381

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Putative stemness gene Jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.2006

    • Author(s)
      Sakaguchi T, et al.
    • Journal Title

      Mol. Cell. Biol 26

      Pages: 6557-6570

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.2006

    • Author(s)
      Ito K, et al.
    • Journal Title

      Nature Med 12

      Pages: 446-451

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.2006

    • Author(s)
      Takubo K, et al.
    • Journal Title

      Biochem Biophys Res Commun. 351

      Pages: 993-998

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells.2006

    • Author(s)
      Ogawa K, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 343

      Pages: 159-166

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.2006

    • Author(s)
      Aoto T, et al.
    • Journal Title

      Dev Biol 298

      Pages: 354-367

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Klf4 cooperates with Oct3/4 and Sox2 to activate the Leftyl core promoter in embryonic stem cells.2006

    • Author(s)
      Nakatake Y, et al.
    • Journal Title

      Mol Cell Biol. 26

      Pages: 7772-7782

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of DNA binding of Sox2 by the SUMO conjugation.2006

    • Author(s)
      Tsuruzoe S, et al.
    • Journal Title

      Biochem Biophys Res Commun 351

      Pages: 920-926

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.2006

    • Author(s)
      Nimura K, et al.
    • Journal Title

      Genes to Cells. 11

      Pages: 1225-1237

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Presenilin-1 controls the growth and differentiation of endothelial progenitor cells through its β-catenin-binding region.2006

    • Author(s)
      Nakajima, M, et al.
    • Journal Title

      Cell Biol. Int 30

      Pages: 239-243

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cardiac ischemia activates vascular endothelial cadherin promoter in both pre-existing vascular cells and bone marrow cells involved in neovascularization.2006

    • Author(s)
      Kogata N, et al.
    • Journal Title

      Circ. Res. 98

      Pages: 897-904

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Over-expression of c-Myb increases the frequency of hemogenic precursors in the endothelial cell population.2006

    • Author(s)
      Dai G, et al.
    • Journal Title

      Genes Cells 11

      Pages: 859-870

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Accelerated acquisition of permeability barrier function in the skin of presenilin-1-deficient embryos.2006

    • Author(s)
      Nakajima M, et al.
    • Journal Title

      Arch. Dermatol. Res. 298

      Pages: 339-345

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mouse epiblast changes responsiveness to BMP4 signal required for PGC formation by the functions of extraembryonic ectoderm.2005

    • Author(s)
      Okamura D.et al.
    • Journal Title

      Mol.Reprod.Dev. 70

      Pages: 20-29

    • Related Report
      2004 Annual Research Report
  • [Journal Article] H.A novel mechanism for regulating clonal propagation of mouse ES cells.2004

    • Author(s)
      Ogawa K.et al.
    • Journal Title

      Genes to Cells. 9

      Pages: 471-477

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nuclear transfer of adult bone marrow mesenchymal stem cells Developmental totipotency of tissue-specific stem cells from an adult mammal.2004

    • Author(s)
      Kato Y.et al.
    • Journal Title

      Biol.Reprod. 70

      Pages: 415-418

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Comparison of in vitro development of porcine nuclear transferred oocytes receiving fetal somatic cells by injection and fusion methods.2004

    • Author(s)
      Kawano K, et al.
    • Journal Title

      Cloning and Stem Cells. 6

      Pages: 67-72

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of nuclear transfer procedures on ES-cell cloning efficiency in the mouse2004

    • Author(s)
      Yabuuchi A.et al.
    • Journal Title

      J.Reprod.Dev. 50

      Pages: 263-268

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Effect of the timing of the first cleavage on the developmental potential of nuclear transferred mouse oocytes receiving embryonic stem cells.2004

    • Author(s)
      Kobayashi T, et al.
    • Journal Title

      Theriogenology. 62

      Pages: 854-860

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Histone code modifications on pluripotential nuclei of reprogrammed somatic cells.2004

    • Author(s)
      Tada M.et al.
    • Journal Title

      Mol.Cell.Biol. 24

      Pages: 5710-5720

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.2004

    • Author(s)
      Kaneda M.et al.
    • Journal Title

      Nature. 429

      Pages: 990-903

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells.2004

    • Author(s)
      Miyagi S, et al.
    • Journal Title

      Mol.Cell.Biol. 24

      Pages: 4207-4220

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Slx1 controls patterning of the mouse otic vesicle.2004

    • Author(s)
      Ozaki H.et al.
    • Journal Title

      Development. 131

      Pages: 551-562

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Essential roles of Meltrin β (ADAM19) in heart development.2004

    • Author(s)
      Kurohara K.et al.
    • Journal Title

      Dev.Biol. 267

      Pages: 14-28

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatocyte growth factor controls proliferation of cultured epiderma melanoblasts and melanocytes from new born.2004

    • Author(s)
      Hirobe T.et al.
    • Journal Title

      Pigment Cell Res. 17

      Pages: 51-61

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Granulocyte-macrophage colony-stimulating factor is a kelatinocyte-derived factor involved in regulating the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture2004

    • Author(s)
      Hirobe T.et al.
    • Journal Title

      Exp.Cell Res. 297

      Pages: 593-606

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells.2004

    • Author(s)
      Okada Y.et al.
    • Journal Title

      Dev.Biol. 275

      Pages: 142-142

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal2004

    • Author(s)
      Ozawa Y.et al.
    • Journal Title

      Mol.Cell.Neurosci. 26

      Pages: 288-270

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Meteorin : a secreted protein that regulates gilial cell differentiation and promotes axonal extension.2004

    • Author(s)
      Nishino J. et al.
    • Journal Title

      EMBO J. 23

      Pages: 1998-2008

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Unexpectedly efficient homing capacity of purified murine hematopoietic stem cell.2004

    • Author(s)
      Matsuzaki Y.et al.
    • Journal Title

      Immunity. 20

      Pages: 87-93

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The cell cycle regulator Geminin inhibits lox function via direct and Polycomb-mediated interactions.2004

    • Author(s)
      Luo L.et al.
    • Journal Title

      Nature. 427

      Pages: 749-752

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Common chromosome aberrations in immortalized normal foreskin fibroblast cultures following transduction of Cyclin A2 or Cdk1 gene in retroviral vectors.2004

    • Author(s)
      Tresini M.et al.
    • Journal Title

      Exp.Cell Res. 294

      Pages: 406-419

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia.2004

    • Author(s)
      Hashi, Y.et al.
    • Journal Title

      Leukemia. 18

      Pages: 1546-1548

    • Related Report
      2004 Annual Research Report
  • [Journal Article] CD9 is a surface marker on mouse and rat male germline stem cells.2004

    • Author(s)
      Kanatsu-Shinohara M.et al.
    • Journal Title

      Biol.Reprod. 70

      Pages: 70-75

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regulation of mouse spermatogonial stem cell self-renewing division by the pituitary gland.2004

    • Author(s)
      Kanatsu-Shinohara M.et al.
    • Journal Title

      Biol.Reprod. 70

      Pages: 1731-1737

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transgenic mouse produced by retroviral transduction of male Germ line stem cells in vivo.2004

    • Author(s)
      Kanatsu-Shinohara M.et al.
    • Journal Title

      Biol.Reprod. 71

      Pages: 1202-1207

    • Related Report
      2004 Annual Research Report
  • [Journal Article] In vivo and in vitro constant expression of GATA-4 in mouse postnata Sertoli cells.2004

    • Author(s)
      Imai T.et al.
    • Journal Title

      Mol Cellular Endocrinol. 214

      Pages: 107-115

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Abnormal angiogenesis in Foxo1 (FKHR)-deficient mice.2004

    • Author(s)
      Furuyama T.et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 34741-34749

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased Numbers of B-1 cells and Enhanced Responses against Ti-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains.2004

    • Author(s)
      Iseki M.et al.
    • Journal Title

      Mol.Cell.Biol. 24

      Pages: 2243-2250

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.2004

    • Author(s)
      Nakayama N.et al.
    • Journal Title

      Development. 131

      Pages: 229-240

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Impaired IgG production in mice deficient for heat shock transcription factor 1.2004

    • Author(s)
      Inouye S. et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 38701-38709

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Embryonic stem cells are capable of generating a neuronal network in the adult mouse retina.2004

    • Author(s)
      Hara A.et al.
    • Journal Title

      Brain Res. 999

      Pages: 216-221

    • Related Report
      2004 Annual Research Report
  • [Journal Article] c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model.2004

    • Author(s)
      Kato M.et al.
    • Journal Title

      Cancer Res. 64

      Pages: 801-806

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.2004

    • Author(s)
      Horie Y.et al.
    • Journal Title

      J.Clin.Invest. 113

      Pages: 1774-1783

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.2004

    • Author(s)
      Backman SA.et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 101

      Pages: 1725-1730

    • Related Report
      2004 Annual Research Report
  • [Journal Article] PI3-kinase-Medeated Activation of Cofilin Phosphatase Slingshot-1L Controls Inslin-induced Membrane Protrusion.2004

    • Author(s)
      Nishita M.et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 7193-7198

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Human placenta-derived cells have mesenchymal stem/progenitor cell potential.2004

    • Author(s)
      Fukuchi Y.et al.
    • Journal Title

      Stem Cells. 22

      Pages: 649-658

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.2004

    • Author(s)
      Arai F.et al.
    • Journal Title

      Cell. 118

      Pages: 149-161

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Collaboration of Brca1 and Chk2 in tumorigenesis.2004

    • Author(s)
      McPherson J.P.et al.
    • Journal Title

      Genes Dev. 18

      Pages: 1144-1153

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Endothelin-1 regulates the dorsoventral branchial arch patterning in mice.2004

    • Author(s)
      Ozeki, H.et al.
    • Journal Title

      Mechanisms of Development. 121

      Pages: 387-395

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression.2004

    • Author(s)
      Ieda M.et al.
    • Journal Title

      J.Clin.Invst. 113

      Pages: 876-884

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Asymmetric division and lineage commitment at the level of hematopoietic stem cells : inference from differentiation in daughter cell and granddaughter cell pairs.2004

    • Author(s)
      Takano H.et al.
    • Journal Title

      J Exp Med. 199

      Pages: 295-302

    • Related Report
      2004 Annual Research Report
  • [Journal Article] "Homing to Niche," a new criterion for hematopoietic stem cells?2004

    • Author(s)
      Ema H.et al.
    • Journal Title

      Immunity 20

      Pages: 1-2

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.2004

    • Author(s)
      Sumazaki R.et al.
    • Journal Title

      Nat Genet. 6

      Pages: 83-87

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting.2004

    • Author(s)
      Suzuki A.et al.
    • Journal Title

      Diabetes. 53

      Pages: 2143-2152

    • Related Report
      2004 Annual Research Report
  • [Journal Article] The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells.2004

    • Author(s)
      Miyagi S.et al.
    • Journal Title

      Mol Cell Biol. 24

      Pages: 4207-4220

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Molecular and clinical basis for the regeneration of human gastrointestinal epithelia.2004

    • Author(s)
      Okamoto R.et al.
    • Journal Title

      J Gastroenterol. 39

      Pages: 1-6

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene express and production of interleukin-7 in human intestinal epithelial cells.2004

    • Author(s)
      Oshima S.et al.
    • Journal Title

      Mol Cell Biol. 24

      Pages: 6298-6310

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of TIE2 signaling in vascular progenitor cells.2004

    • Author(s)
      Suzuki Y.et al.
    • Journal Title

      Blood. 104

      Pages: 166-169

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Dehydroepiandrosterone decreases elevated hepatic glucose production in C57BL/KsJ-db mice.2004

    • Author(s)
      Aoki K.et al.
    • Journal Title

      Life Sciences. 74

      Pages: 3075-3084

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34^+CD38^- cells : possible role of VIP as a growth-promoting factor for hepatopoiet stem/progenitor cells.2004

    • Author(s)
      Kawakami, M.
    • Journal Title

      Leukemia. 18

      Pages: 912-921

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pyrazolo pyrimidine-type inhibitors of src family tyrosine kinases promote ovarian steroid-induced differentiation of human endometrial stromal cells in vitro.2004

    • Author(s)
      Maruyama T.et al.
    • Journal Title

      Biol Reprod. 70

      Pages: 214-221

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer.2004

    • Author(s)
      Teranishi T.et al.
    • Journal Title

      Dev.Biol. 266

      Pages: 76-86

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction.2004

    • Author(s)
      Kawada H.et al.
    • Journal Title

      Blood. 104

      Pages: 3581-3587

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients.2004

    • Author(s)
      Nakayama Y. et al.
    • Journal Title

      Am.J.Pathol. 164

      Pages: 1773-1782

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression and the biological activities of insulin-like growth factor-binding protein related protein 1 (IGFBP-rP1/mac25) in rat uterus during the pen-implantation period.2004

    • Author(s)
      Tamura K.et al.
    • Journal Title

      Endocrinol. 145

      Pages: 5243-5251

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice2004

    • Author(s)
      Sakurai K.et al.
    • Journal Title

      Gene Therapy. 11

      Pages: 1475-1481

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Expression of a Novel Human Gene, Human Wings Apart-Like (hWAPL), Is Associated with Cervical Carcinogenesis and Tumor Progression.2004

    • Author(s)
      Oikawa K.et al.
    • Journal Title

      Cancer Res. 64

      Pages: 3545-3549

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Developmental totipotency of tissue-specific stem cells from an adult mammal Nuclear transfer of adult bone marrow mesenchymal stem cells.2004

    • Author(s)
      Kato Y.et al.
    • Journal Title

      Biol Reprod. 70

      Pages: 415-418

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Hrp48 regulates couples oskar mRNA localization and translational control during Drosophila oogenesis.2004

    • Author(s)
      Yano T.et al.
    • Journal Title

      Dev.Cell. 6

      Pages: 637-648

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Regulation of expression of mouse interferon-induced transmembrane protein like gene-1, Ifitm3 (mil-1/fragilis), in germ cells.2004

    • Author(s)
      Tanaka S.S.et al.
    • Journal Title

      Dev.Dyn. 231

      Pages: 651-659

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Generation of functional platelets from human embryonic stem cells in vitro via ES-saces, VEGF-promoted structures that concentrate hematopoietic progenitors.

    • Author(s)
      Takayama N, et. al.
    • Journal Title

      Blood. (In Press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Book] 再生医療のしくみ2006

    • Author(s)
      八代嘉美, 中内啓光
    • Total Pages
      166
    • Publisher
      日本実業出版社
    • Related Report
      2006 Annual Research Report
  • [Publications] Matsuda E. et al.: "Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis"Proc Natl Acad Sci U S A.. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakayama, N. et al.: "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage."Development. 23. 229-240 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takano H. et al.: "Asymmetric division and lineage commitment at the level of hematopoietic stem cells : inference from differentiation in daughter cell and granddaughter cell pairs."J Exp Med.. 199. 295-302 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sumazaki R, et al.: "Conversion of biliary system to pancreatic tissue in Hesl-deficient mice"Nature Genetics. 6. 83-87 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mak W, et al.: "Reactivation of the paternal X chromosome in early mouse embryos."Science. 303. 666-669 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sato, A. et al.: "Zinc-finger protein Sall2 is not essential for embryonic and kidney development"Mol.Cell.Biol. 23. 62-69 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Senga, T., et al.: "LSSIG is a novel murine leukocyte specific GPCR that is induced by the activation of STAT3."Blood. 101. 1185-1187 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tokuzawa Y., et al.: "Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development."Mol Cell Biol.. 23(8). 2699-2703 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Mitsui K., et al.: "The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."Cell.. 113. 631-642 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tateishi, S., et al.: "Yamaizumi, M. Enhanced genomic instability and defective postreplication repair in RAD18-knockout mouse embryonic stem cells."Mol.Cell.Biol.. 23. 474-481 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tokuzawa, Y., et al.: "Fbx15 is a novel target of Oct3/4 but is ensable for ES cell self-renewal and mouse development"Mol.Cell.. 23. 2699-2708 (2003)

    • Related Report
      2003 Annual Research Report

URL: 

Published: 2002-04-01   Modified: 2018-03-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi