Grant-in-Aid for Scientific Research (S)
|Allocation Type||Single-year Grants |
Biomedical engineering/Biological material science
|Research Institution||Tohoku University (2004-2005)|
The University of Tokyo (2002-2003)
IMACHI Kou Tohoku University, Biomedical Engineering Research Organization, Professor, 先進医工学研究機構, 教授 (10010076)
TAKIURA Koki Tohoku University, Biomedical Engineering Research Organization, Associate Professor, 先進医工学研究機構, 助教授 (60375194)
YAMBE Tomoyuki Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (70241578)
ABE Yusuke University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授 (90193010)
MOCHIZUKI Shuichi University of Tokyo, Graduate School of Medicine, Instructor, 大学院医学系研究科, 助手 (00345042)
SAITO Itsuro University of Tokyo, Research Center for Advanced Science and Technology, Instructor, 先端科学技術研究センター, 助手 (80334225)
鎮西 恒雄 東京大学, 先端科学技術研究センター, 助教授 (20197643)
馬場 敦 国立精神・神経センター, 医師(研究職)
磯山 隆 東京大学, 大学院・医学系研究科, 講師 (20302789)
|Project Period (FY)
2002 – 2005
Completed (Fiscal Year 2005)
|Budget Amount *help
¥102,180,000 (Direct Cost: ¥78,600,000、Indirect Cost: ¥23,580,000)
Fiscal Year 2005: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2004: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2003: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2002: ¥56,290,000 (Direct Cost: ¥43,300,000、Indirect Cost: ¥12,990,000)
|Keywords||CCD / Microcirculation / Artificial heart / Pulsatile flow / Continuous flow / Flow rate of erythrocyte / Circulatory control / Probe to observe microcirculation / 赤血球速度|
Although many types of continuous flow ventricular assist devices have become to use clinically as the bridge to heart transplantation, no body knows whether the pulsatility of blood flow is essential for living body or not. We have succeeded the basic development to solve the problem ; undulation pump AH(UPAH) and CCD probe. UPAH can change instantaneously its flow patterns by computer control of motor rotational speed. CCD probe is implantable micro-camera to observe microcirculation chronically.
The objective of this study is to clarify the necessity of pulsatility for the living body by developing more completely UPTAH and CCD probe. The following outcome has been gotten in these 4 years :
Blood compatibility, durability and size ＆ weight were improved great deal. The goat implanted UPAH survived maximally 4 months without anticoagulant. The software to control blood waveform has also been developed.
High magnification, focus adjust system and miniaturization were the objective to be developed. A micro-lens, 2 mm in diameter and 2 mm long was developed. The lens was installed into a CCD camera having 8 mm in diameter and 60 mm long. Total magnification on 14 inch TV screen was 650 times, that was enough to observe the erythrocyte flow in a capillary vessel. It could be implanted in an animal without difficulty. Residual problem is focus adjusting system.
3)Microcirculation under UPAH
The blood flow pattern was changed instantaneously from pulsatile to continuous when UPAH goat recover from surgical stress. The microcirculation was observed at bulbar conjunctiva during experiment. Following phenomena were observed until now : (1)Capillary density that is the ratio of the flowing capillaries to total capillary number, was decreased 30%. (2)The erythrocyte flow rate in the capillary was decreased 75 and some of them did not recover after the flow pattern returned to pulsatile.