| Co-Investigator(Kenkyū-buntansha) |
MATSUSHIMA Masato Jikei University School of Medicine, Department of Internal Medicine, Lecturer, 医学部, 講師 (50246443)
NIISHIMURA Rimeii Jikei University School of Medicine, Department of Internal Medicine, Assistant, 医学部, 助手 (20343535)
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| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2004: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2003: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2002: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Research Abstract |
Type 2 diabetes among children is a global problem, which closely relates to an increase in the number of obese children. The current study evaluated the annual change of the prevalence of childhood obesity and obesity-related indices in the established population-based cohort in Ina-town, Saitama Prefecture.
The subjects were 9-10 year-old and 12-13 year-old children from all the public schools in Ina-town, Saitama Prefecture. A total number was 1,966 and the number of children in each age group were 315 and 311 in 2002,353 and 291 in 2003,385 and 310 in 2004. The children underwent physical check-ups including venous blood sampling to measure serum levels of total cholesterol (TC), triglyceride(TG), plasma glucose(PG), HbAlc, serum insulin, adiponectin, leptin and TNF-α. Ascertainment rate was over 95%, and written informed consent were obtained from children and their parents.
Obesity was defined as being≧120% of overweight(POW) compared to the sex- and age-matched ideal standardized
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body weights for Japanese children. The prevalence rate of obesity in 9-10 year olds tended to decline from 14.9%(2002),12.8%(2003) to 9.6%(2004), whereas those in 12-13 year olds slightly increased from 9.4%(2002), 9.6%(2003) to 11.9%(2004). Overt type 2 diabetes was not detected. The levels of serum adiponectin were statistically lower in obese children compared to those without obesity, with the exception of 9-10 year-old boys. The levels of serum leptin were statistically higher in obese children compared to those without obesity, irrespective of age and gender.
The median of serum adiponectin (μg/dl)(non-obese/obese) was statistically lower in obese children (9.6/8.3,p<0.01), and the median of serum leptin (ng/dl) was statistically higher in obese children (3.7/12.5,p<0.05). The medians of serum HbA1c(%)(4.7/4.7,p<0.01), PG(mg/dl)(92/89,p<0.001) and serum insulin(μU/ml)(13/8) were statistically higher than those in non-obese children. No significant correlation was found between TNFα and obesity.
A large-scale, population-based study revealed that the serum adiponectin level was lower and the leptin, HbA1c and glucose levels were higher in obese children, as was reported in adults. Less
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