Analysis of Mucosal Immunity by the Fc receptor for IgA and IgM
| Project/Area Number |
14207024
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHIBUYA Akira University of Tsukuba, Department of Immunology, Professor, 大学院・人間総合科学研究科, 教授 (80216027)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥43,160,000 (Direct Cost: ¥33,200,000、Indirect Cost: ¥9,960,000)
Fiscal Year 2004: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2003: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2002: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
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| Keywords | Fcα / μ receptor / IgA / IgM / Paneth cell / Antibacteria / Fc receptor / 自然免疫 / 獲得免疫 / 免疫グロブリン / 生体防御 |
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| Research Abstract |
We previously identified an Fc receptor for IgA and IgM (Fcα/μ receptor), which is expressed on antigen presenting cells. We found that the Fcα/μ receptor mediated endocytosis of IgM immune complex with antigen, such as staphylococcus aureus, suggesting an important mechanisms of pathogen eradication by IgM. The present study aims to clarify a role of the Fcα/μ receptor in mucosal immunity. We have identified several isoforms of the soluble Fcα/μ receptor expressed on intestinal Paneth cells and epithelial cells of urinary tract. We found that the extracellular domain of the isoforms may have antimicrobial activity against E.coli. Furthermore, we observed that mice deficient in the Fcα/μ receptor gene exhibited high IgA concentration in both serum and fecus and the presence of many IgA producing cells in lamina proplia.
We also observed that the Fcα/μ receptor was strongly expressed on the area of germinal center. Immunohistochemical study revealed that FDC substantially expressed the Fcα/μ receptor in germinal center. These results suggest that the Fcα/μ receptor regulates IgA production in peyel's patches and/or intestinal flora by the soluble Fcα/μ receptor secreted from Paneth cells. Furthermore, we studied the mucosal immune responses by antigen challenge in mice deficient in the the Fcα/μreceptor gene.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Treatment with alpha-galactosylceramide attenuates the development of bleomycin-induced pulmonary fibrosis.2004
Author(s)
Kimura T, Ishii Y, Morishima Y, Shibuya A, Shibuya K, Taniguchi M, Mochizuki M, Hegab AE, Sakamoto T, Nomura A, Sekizawa K.
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Journal Title
J Immunol. 172
Pages: 5782-5789
Description
「研究成果報告書概要(欧文)」より
Related Report
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