| Project/Area Number |
14370082
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
IKEHARA Susumu Kansai Medical University, Faculty of medicine, Professor, 医学部, 教授 (90108986)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Yasushi Kansai Medical University, Faculty of medicine, Associate Professor, 医学部, 助教授 (10268336)
YASUMIZU Ryoji Kansai Medical University, Faculty of medicine, Associate Professor, 医学部, 助教授 (00142753)
INABA Muneo Kansai Medical University, Faculty of medicine, Associate Professor, 医学部, 助教授 (70115947)
HISHA Hiroko Kansai Medical University, Faculty of medicine, Associate Professor, 医学部, 講師 (90151422)
TOKI Junko Kansai Medical University, Faculty of medicine, Associate Professor, 医学部, 講師 (40077681)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2003: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2002: ¥8,600,000 (Direct Cost: ¥8,600,000)
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| Keywords | bone marrow transplantation / organ transplantation / hemopoietic stem cell / mesenchymal stem cell / regeneration medicne / 骨髄内骨髄移植 / 灌流法 / 難病 / 自己免疫疾患 / カニクイザル / 再生医学 |
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| Research Abstract |
We have recently established a new method for allogeneic bone marrow transplantation(BMT), which includes a "Perfusion Method(PM)" plus "Intra-Bohe Marrow(IBM)-BMT". This method allowed us to recruit not only pluripotent hemopoietic stem cells(P-HSCs) but also mesenchymal stem cells(MSCs), and we have therefore succeeded in treating osteoporosis, emphysema, and sensorineural hearing loss.
I addition, we have succeeded in transplantating alloorgans such as the skin, pancreas, and also leg, even when the radiation dose is reduced to 4Gy x 2. For the human application of this new method, we have used cynomolgus monkeys and found that donor lymphocyte infusion in conjunction with IBM-BMT is so far the best strategy, since the radiation dose can be reduced to 4Gy x 2.
We believe this new method will become a valuable strategy for the treatment of various intractable diseases.
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