Th1/Th2 cell differentiation and chromatin remodeling of the Th2 cytokine gene locus

• Project/Area Number: 14370107
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Chiba University
• Principal Investigator: NAKAYAMA Toshinori Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (50237468)
• Project Period (FY): 2002 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥13,900,000 (Direct Cost: ¥13,900,000); Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000); Fiscal Year 2003: ¥4,000,000 (Direct Cost: ¥4,000,000); Fiscal Year 2002: ¥7,200,000 (Direct Cost: ¥7,200,000)
• Keywords: Th2 cell / chromatin remodeling / CGRE / ROG / bmi-1 / polycomb / histone acetylation / IL-4 / ポリコーム遺伝子 / Ring1B / Th1 / Th2 / アレルギー / 気道炎症 / Th2サイトカイン / GATA3 / リモデリング / Th2サイトカン

Research Abstract

Differentiation of naive CD4 T cells into Th2 cells is accompanied by chromatin remodeling including hyperacetylation of histones H3 and H4 in the nucleosomes associated with the IL-4,IL-13 and IL-5 genes. A conserved GATA3 response element (CGRE) containing four GATA consensus sequences was identified 1.6 kbp upstream of the IL-13 gene, corresponding with the 5' border of the Th2-specific histone hyperacetylation region. The CGRE was shown to bind to GATA3, histone acetyl transferase complexes including CBP/p300, and RNA polymerase II. Thus, the CGRE may play a crucial role for GATA3-mediated targeting and downstream spreading of core histone hyperacetylation within the IL-13 and IL-4 gene loci. As for the IL-5 gene locus, CD28-costimulation selectively enhanced histone hyperacetylation through NF-kB activation and subsequent upregulation of GATA3. Chromatin remodeling of type 2 cytokine gene loci occurs also in developing CD8 Tc2 T cells. IL-4 production and histone hyperacetylation in IL-4-associated nucleosomes in developing Tc2 cells were significantly lower than those of Th2 cells, however, cytokine production and histone hyperacetylation of IL-5 and IL-13 genes were equivalent. Developing Tc2 cells expressed lower GATA3 levels and dramatically increased levels of repressor of GATA (ROG). A ROG response element in the IL-13 gene exon 4 displayed Tc2-specific bin4ing of ROG,HDAC1 and HDAC2, and exhibited repression of IL-4 gene activation. Thus, ROG may confer CD8 T cell-specific repression of histone hyperacetylation and activation of the IL-4 gene locus.

Research Products

• [Journal Article] Regulation of Th2 cell differentiation by murine Schnurri-2. (2005)
  • Author(s): Kimura, M.
  • Journal Title: J.Exp.Med. 201 Pages: 397-408
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulation of Th2 cell differentiation by murine Schnurri-2. (2005)
  • Author(s): Kimura, M., Hosokawa, H., Yamashita, M., Watarai, H., Hasegawa, A., Iwamura, C., Taniguchi, M., Takagi, T., Ishii, S., Nakayama, T.
  • Journal Title: J.Exp.Med. 201 Pages: 397-408
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. (2004)
  • Author(s): Koike, J.
  • Journal Title: J.Exp.Med. 199 Pages: 137-143
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor, MIF in human dermal fibroblasts. (2004)
  • Author(s): Watanabe, H.
  • Journal Title: J.Biol., Chem. 279 Pages: 1676-1683
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fas disabling small exocyclic peptide mimetecs limit apoptosis by an unexpected mechanism. (2004)
  • Author(s): Hasegawa, A.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 6599-6604
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD28 costimulation controls histone hyperacetylation of the IL-5 gene locus in developing Th2 cells. (2004)
  • Author(s): Inami, M.
  • Journal Title: J.Biol.Chem. 279 Pages: 23123-23133
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Essential role of GATA3 for the maintenance of Type 2 helper T, Th2 cytokine production and chromatin remodeling at the Th2 cytokine gene loci. (2004)
  • Author(s): Yamashita, M.
  • Journal Title: J.Biol.Chem. 279 Pages: 26983-26990
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of a NK receptor, KLRE-1, in bone marrow allograft rejection : analysis with KLRE-1 deficient mice. (2004)
  • Author(s): Shimizu, E.
  • Journal Title: Blood 104 Pages: 781-783
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. (2004)
  • Author(s): Yamashita, M.
  • Journal Title: IJ.Biol.Chem. 279 Pages: 39454-39464
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Natural killer T cells accelerate atherogenesis in mice. Short title : NKT cells and atherosclerosis in mice. (2004)
  • Author(s): Nakai, Y.
  • Journal Title: Blood 104 Pages: 2051-2059
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. (2004)
  • Author(s): Diao, H.
  • Journal Title: Immunity 21 Pages: 539-550
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] STAT6-dependent differentiation and production of IL-5 and IL-3 in murine NK2 cells. (2004)
  • Author(s): Katsumoto, T.
  • Journal Title: J.Immunol. 173 Pages: 4967-4975
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I. (2004)
  • Author(s): Koike, J., Wakao, H., Ishizuka, Y., Sato, T., Hamaoki, M., Seino, K., Koseki, H., Nakayama, T., Taniguchi, M.
  • Journal Title: J.Exp.Med. 199 Pages: 137-143
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor, MIF in human dermal fibroblasts. (2004)
  • Author(s): Watanabe, H., Shimizu, T., Nishihara, J., Abe, R., Nakayama.T., Taniguchi, M., Sabe, H., Ishibashi, T., Shimizu, H.
  • Journal Title: J.Biol., Chem. 279 Pages: 1676-1683
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fas disabling small exocyclic peptide mimetecs limit apoptosis by an unexpected mechanism. (2004)
  • Author(s): Hasegawa, A., Cheng, X., Kajino, K., Berezov, A., Murata, K., Nakayama.T., Yagita, H., Murali, R., Greene, M.I.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 6599-6604
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD28 costimulation controls histone hyperacetylation of the IL-5 gene locus in developing Th2 cells. (2004)
  • Author(s): Inami, M., Yamashita, M., Tenda, Y., Hasegawa, A., Kimura, M., Hashimoto, K., Seki, N., Taniguchi, M., Nakavama, T.
  • Journal Title: J.Biol.Chem. 279 Pages: 23123-23133
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Essential role of GATA3 for the maintenance of Type 2 helper T, Th2 cytokine production and chromatin remodeling at the Th2 cytokine gene loci. (2004)
  • Author(s): Yamashita, M., Ukai-Tadenuma, M., Miyamoto, T., Sugaya, K., Hosokawa, H., Hasegawa, A., Kimura, M., Taniguchi, M., DeGregori, J., Nakayama, T.
  • Journal Title: J.Biol.Chem. 279 Pages: 26983-26990
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of a NK receptor, KLRE-1, in bone marrow allograft rejection : analysis with KLRE-1 deficient mice. (2004)
  • Author(s): Shimizu, E., Koike, J., Wakao, H., Seino, K., Koseki, H., Kakiuchi, T., Nakayama.T., Taniguchi, M.
  • Journal Title: Blood 104 Pages: 781-783
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interleukin, IL-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. (2004)
  • Author(s): Yamashita, M., Shinnakasu, R., Nigo, Y., Kimura, M., Hasegawa, A., Taniguchi, M., Nakayama, T.
  • Journal Title: J.Biol.Chem. 279 Pages: 39454-39464
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural killer T cells accelerate atherogenesis in mice. Short title : NKT cells and atherosclerosis in mice. (2004)
  • Author(s): Nakai, Y, Iwabuchi, K., Fujii, S., Ishimori, N., Dashtsoodol, N., Watano, K., Mishima, T., Iwabuchi, C., Tanaka, S., Bezbradica, J.S., Nakayama, T., Taniguchi, M., Miyake, S., Yamamura, T., Kitabatake, A., Joyce, S., Van Kaer, L., Onoe, K.
  • Journal Title: Blood 104 Pages: 2051-2059
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. (2004)
  • Author(s): Diao, H., Kon, S., Iwabuchi, K., Kimura, C., Morimoto, J., Ito, D., Segawa, T., Maeda, M., Hamuro, J., Nakayama, T., Taniguchi, M., Yagita, H., Van Kaer, L., Onoe, K., Denhardt, D., Rittling, S., Uede, T.
  • Journal Title: Immunity 21 Pages: 539-550
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. (2004)
  • Author(s): Katsumoto, T., Kimura, M., Yamashita, M., Hosokawa, H., Hashimoto, K., Hasegawa, A., Omori, M., Miyamoto, T., Taniguchi, M., Nakayama, T.
  • Journal Title: J.Immunol. 173 Pages: 4967-4975
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fasdisabling small exocyclic peptide mimetecs limit apoptosis by an unexpected mechanism. (2004)
  • Author(s): Hasegawa, A.
  • Journal Title: Proc.Natl.Acad.Sci.USA 101 Pages: 6599-6604
• [Journal Article] Interleukin, IL-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells. (2004)
  • Author(s): Yamashita, M.
  • Journal Title: J.Biol.Chem. 279 Pages: 39454-39464
• [Journal Article] STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. (2004)
  • Author(s): Katsumoto, T.
  • Journal Title: J.Immunol. 173 Pages: 4967-4975
• [Journal Article] src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. (2003)
  • Author(s): Kamata, T.
  • Journal Title: J.Clin.Invest. 111 Pages: 109-119
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. (2003)
  • Author(s): Kubo, S.
  • Journal Title: J.Immunol. 170 Pages: 775-780
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen induced airway hyperreactivity. (2003)
  • Author(s): Akbari, O.
  • Journal Title: Nat.Med. 9 Pages: 582-588
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Estrogen modulates cutaneous wound healing by down-regulating macrophage migration inhibitory factor. (2003)
  • Author(s): Ashcroft, G.S.
  • Journal Title: J.Clin.Invest. 111 Pages: 1309-1318
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Th1-biased immunity induced by exposure to Antarctic winter. (2003)
  • Author(s): Shirai, T.
  • Journal Title: J.Allergy Clin.Immunol. 111 Pages: 1353-1360
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. (2003)
  • Author(s): Shimonaka, M.
  • Journal Title: J.Cell Biol. 161 Pages: 417-427
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Impaired contact hypersensitivity in macrophage migration inhibitory factor, MIF-deficient mice. (2003)
  • Author(s): Shimizu, T.
  • Journal Title: Eur.J.Immunol. 33 Pages: 1478-1487
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. (2003)
  • Author(s): Omori, M.
  • Journal Title: Immunity 19 Pages: 281-294
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD69-null mice protected from arthritis induced with anti-Type II collagen antibodies. (2003)
  • Author(s): Murata, K.
  • Journal Title: Int.Immunol. 8 Pages: 987-992
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The regulatory role of Vα14 NKT cells in innate and acquired immune response. (2003)
  • Author(s): Taniguchi, M.
  • Journal Title: Ann.Rev.Immunol. 21 Pages: 483-513
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The NKT cell system : bridging innate and acquired immunity. (2003)
  • Author(s): Taniguchi, M.
  • Journal Title: Nat.Immunol. 4 Pages: 1164-1165
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. (2003)
  • Author(s): Kamata, T., Yamashita, M., Kimura, M., Murata, K., Inami M, Shimizu, C., Sugaya, K., Wang C.-R., Taniguchi, M., Nakayama, T.
  • Journal Title: J.Clin.Invest. 111 Pages: 109-119
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. (2003)
  • Author(s): Kubo, S., Nakayama, T., Matsuoka, K., Yonekawa, H., Karasuyama, H.
  • Journal Title: J.Immunol. 170 Pages: 775-780
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Critical role of NKT cells producing IL-4 and IL-13 in the development of allergen induced airway hyperreactivity. (2003)
  • Author(s): Akbari, O., Meyer, E., Stock, P., Kronenberg, M., Sidobre, S., Nakayama, T., Taniguchi, M., Grusby, M.J., DeKruyff, R.H., Uematsu, D.T.
  • Journal Title: Nat.Med. 9 Pages: 582-588
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Estrogen modulates cutaneous wound healing by down-regulating macrophage migration inhibitory factor. (2003)
  • Author(s): Ashcroft, G.S., Mills, S.J., Lei, K., Gibbons, L., Burow, M., Jeong, M-J., Taniguchi, M., Horan, M.A., Wahl, S.M., Nakayama, T.
  • Journal Title: J.Clin.Invest. 111 Pages: 1309-1318
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Th1-biased immunity induced by exposure to Antarctic winter. (2003)
  • Author(s): Shirai, T., Magara, K.K., Motohashi, S., Yamashita, M., Kimura, M., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M., Nakayama, T.
  • Journal Title: J.Allergy Clin.Immunol. 111 Pages: 1353-1360
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. (2003)
  • Author(s): Shimonaka, M., Katagiri, K., Nakayama, T., Fujita, N., Tsuruo, T., Yoshie, O., Kinashi, T.
  • Journal Title: J.Cell Biol. 161 Pages: 417-427
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impaired contact hypersensitivity in macrophage migration inhibitory factor, MIF-deficient mice. (2003)
  • Author(s): Shimizu, T., Abe, R., Nishihara, J., Shibaki, A., Watanabe, H., Nakayama, T., Taniguchi, M., Ishibashi, T., Shimizu, H.
  • Journal Title: Eur.J.Immunol. 33 Pages: 1478-1487
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, represser of GATA. (2003)
  • Author(s): Omori, M., Yamashita, M., Inami, M., Ukai-Tadenuma, M., Kimura, M., Nigo, Y., Hosokawa, H., Hasegawa, A., Taniguchi, M., Nakayama, T.
  • Journal Title: Immunity 19 Pages: 281-294
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD69-null mice protected from arthritis induced with anti-Type II collagen antibodies. (2003)
  • Author(s): Murata, K., Inami, M., Hasegawa, A., Kubo, S., Kimura, M., Yamashita, M., Hosokawa, H., Nagao, T., Suzuki, K., Hashimoto, K., Shinkai, H., Koseki, H., Taniguchi, M., Ziegler, S.F., Nakayama.T.
  • Journal Title: Int.Immunol. 8 Pages: 987-992
  • NAID: 10014342570
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The regulatory role of Vα14 NKT cells in innate and acquired immune response. (2003)
  • Author(s): Taniguchi, M., Harada, M., Nakayama, T., Wakao, H.
  • Journal Title: Ann.Rev.Immunol. 21 Pages: 483-513
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The NKT cell system : bridging innate and acquired immunity. (2003)
  • Author(s): Taniguchi, M., Seino K., Nakayama,.T.
  • Journal Title: Nat.Immunol. 4 Pages: 1164-1165
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. (2002)
  • Author(s): Nakayama, T.
  • Journal Title: J.Immunol. 168 Pages: 87-94
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] CD4^+ CD25^+ T-cell development is regulated by at least 2 distinct mechanisms. (2002)
  • Author(s): Suto, A.
  • Journal Title: Blood 99 Pages: 555-560
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Natural killer T cell ligand a-galactosylceramide enhances protective immunity induced by malaria vaccines. (2002)
  • Author(s): Gonzalez-Aseguinolaza, G.
  • Journal Title: J.Exp.Med. 195 Pages: 617-624
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. (2002)
  • Author(s): Shibata, Y.
  • Journal Title: J.Immunol. 169 Pages: 2134-2140
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] T_h1/T_h2 cell differentiation of developing CD4 single-positive thymocytes. (2002)
  • Author(s): Kikkawa, E.
  • Journal Title: Int.Immunol. 14 Pages: 943-951
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Identification of a conserved GATA3 response element upstream proximal of the IL-13 gene locus. (2002)
  • Author(s): Yamashita, M.
  • Journal Title: J.Biol.Chem. 277 Pages: 42399-42408
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Preserved IFN-γ production of circulating Vα24 NKT cells in primary lung cancer patients. (2002)
  • Author(s): Motohashi, S.
  • Journal Title: Int.J.Cancer. 102 Pages: 159-165
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27^<kip1> degradation. (2002)
  • Author(s): Asai, K.
  • Journal Title: J.Immunol. 169 Pages: 4723-4731
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. (2002)
  • Author(s): Nakayama, T., Kasprowicz, D.J., Yamashita, M., Schubert, L.A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H., Ziegler, S.F.
  • Journal Title: J.Immunol. 168 Pages: 87-94
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD4^+ CD25^+ T-cell development is regulated by at least 2 distinct mechanisms. (2002)
  • Author(s): Suto, A., Nakajima, H., Ikeda, K., Kubo, S., Nakayama, T., Taniguchi, M., Saito, Y., Iwamoto, I.
  • Journal Title: Blood 99 Pages: 555-560
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Natural killer T cell ligand α-galactosylceramide enhances protective immunity induced by malaria vaccines. (2002)
  • Author(s): Gonzalez-Aseguinolaza, G., Van Kaer, L., Bergmann, C.C., Wilson, J.M., Schmieg, J., Kronenberg, M., Nakayama, T., Taniguchi, M., Koezuka, Y., Tsuji, M.
  • Journal Title: J.Exp.Med. 195 Pages: 617-624
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation. (2002)
  • Author(s): Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, C.-R., Murata, K., Miyazaki, M., Taniguchi, M., Watanabe, N., Nakayama, T.
  • Journal Title: J.Immunol. 169 Pages: 2134-2140
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] T_h1/T_h2 cell differentiation of developing CD4 single-positive thymocytes. (2002)
  • Author(s): Kikkawa, E., Yamashita, M., Kimura, M., Omori, M., Sugaya, K., Shimizu, C., Katsumoto, T., Ikekita, M., Taniguchi, M., Nakayama, T.
  • Journal Title: Int.Immunol. 14 Pages: 943-951
  • NAID: 10013884085
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of a conserved GATA3 response element upstream proximal of the IL-1 3 gene locus. (2002)
  • Author(s): Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M., Nakayama, T.
  • Journal Title: J.Biol.Chem. 277 Pages: 42399-42408
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Preserved IFN-γ production of circulating Vα24 NKT cells in primary lung cancer patients. (2002)
  • Author(s): Motohashi, S., Kobayashi, S., Magara, K., Iizasa, T., Nakayama, T., Fujisawa, T., Taniguchi, M.
  • Journal Title: Int.J.Cancer 102 Pages: 159-165
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] T cell hyporesponsiveness induced by oral administration of ovalbumm is associated with impaired NFAT nuclear translocation and p27^<kip1> degradation. (2002)
  • Author(s): Asai, K., Hachimura, S., Kimura, M., Toraya, T., Yamashita, M., Nakayama, T., Kaminogawa, S.
  • Journal Title: J.Immunol. 169 Pages: 4723-4731
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kamata, T.: "src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation."J.Clin.Invest.. 111. 109-119 (2003)
• [Publications] Ashcroft, G.S.: "Estrogen modulates cutaneous wound healing by down-regulating macrophage migration inhibitory factor."J.Clin.Invest.. 111. 1309-1318 (2003)
• [Publications] Shirai, T.: "Th1-biased immunity induced by exposure to Antarctic winter."J.Allergy Clinical Immunol.. 111. 1353-1360 (2003)
• [Publications] Shimonaka, M.: "Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow."J.Cell Biol.. 161. 417-427 (2003)
• [Publications] Murata, K.: "CD69-null mice protected from arthritis induced with anti-Type II collagen antibodies."Int.Immunol.. 8. 987-992 (2003)
• [Publications] Omori, M.: "CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA."Immunity. 19. 281-294 (2003)
• [Publications] Nakayama, T., Kasprowicz, D.J., Yamashita, M., Schubert, L.A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H., Ziegler, S.F: "The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression"J. Immunol.. 168. 87-94 (2002)
• [Publications] Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, C.-R., Murata, K., Miyazaki.M., Taniguchi, M., Watanabe, N., Nakayama, T.: "Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation"J. Immunol.. 169. 2134-2140 (2002)
• [Publications] Kikkawa, E., Yamashita, M., Kimura, M., Omori, M., Sugaya, K., Shimizu, C., Katsumoto, T., Ikekita, M., Taniguchi, M., Nakayania, T.: "T_h1/T_h2 cell differentiation of developing CD4 single-positive thymocytes"Int. Immunol.. 14. 943-951 (2002)
• [Publications] Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M., Nakayama, T: "Identification of a conserved GATA3 response element upstream proximal of the IL-13 gene locus"J. Biol. Chem.. 277. 42339-42408 (2002)
• [Publications] Kamata, T., Yamashita, M., Kimura, M., Murata, K., Inami M., Shimizu, C., Sugaya, K., Wang C.-R., Taniguchi, M., Nakayama, T.: "src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation"J. Clin. Inv.. 111. 109-119 (2003)
• [Publications] Ashcroft, G.S., Mills, S.J., Lei, K., Gibbons, L., Burow, M., Jeong, M-J., Taniguchi, M., Horan, M.A., Wahl, S.M., Nakayama, T.: "Estrogen modulates cutaneous wound healing by down-regulating macrophage migration inhibitory factor"J. Clin. Inv.. (in press).
• [Publications] Taniguchi, M., Harada, M., Nakayama, T., Wakao, H: "Ann. Rev. Imm"The regulatory role of Vα14 NKT cells in innate and acquired immune response(in press).