| Project/Area Number |
14370213
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tokyo Medical and Dental University (2003)
Tokyo Metropolitan Organization for Medical Research (2002) |
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Principal Investigator |
OKAZAWA Hitoshi Tokyo Medical and Dental University, Medical Research institute, Professor, 難治疾患研究所, 教授 (50261996)
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| Co-Investigator(Kenkyū-buntansha) |
KANAZAWA Ichiro National Center for Psychiatry and neurology, DEAN, 総長 (30110498)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 2003: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2002: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | POLYGLUTAMINE DISEASES / MEURODEGENTATION / PQBP-1 / TRANSCRIPTION / NUCLEARFUNCTION / RNA POLYMERASE II |
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| Research Abstract |
Polyglutamine diseases are caused by abnormal proteins containing an elongated polyglutamine tract sequence. It is generally believed that aggregation of the mutant proteins is essential for the pathology. However, molecular events induced by abnormal proteins during aggregation process are not fully elucidated. In this project, we applied genomics and proteomics to this question and investigated which genes and proteins are affected in expression. In brief, we found that different disease genes cause different gene and protein expression changes in a neuron type-specific manner. During the process, we found novel modifier genes of polyglutamine disease pathology, which could be used for the future development of molecular therapeutics.
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