Research on a new internal radiation therapy agent targeting for hypoxic tumors.
| Project/Area Number |
14370274
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui (2004)
福井医科大学 (2002-2003) |
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Principal Investigator |
FUJIBAYASHI Yasuhisa University of Fukui, Biomedical Imaging Research Center, Professor, 高エネルギー医学研究センター, 教授 (50165411)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Harumi University of Fukui, School of Medicine, Professor, 医学部, 教授 (40026943)
KAWAI Keiichi Kanazawa University, School of Medicine, Professor, 医学部 福井大学・高エネルギー医学研究センター, 教授 客員教授(併任) (30204663)
FURUKAWA Takako University of Fukui, Biomedical Imaging Research Center, Associate professor, 高エネルギー医学研究センター, 助教授 (00221557)
KONNO Takashi University of Fukui, School of Medicine, Associate Professor, 医学部, 助教授 (50225637)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2004: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 2003: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥5,900,000 (Direct Cost: ¥5,900,000)
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| Keywords | Cu-64 / beta emitter / cyclotron / tumor / internal radiation therapy / hypoxia / hypoxia / Hypoxia |
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| Research Abstract |
Intratumoral distribution of [Cu-64]Cu-diacetyl-bis (N4-methylthiosemicarbazone) (^<64>Cu-ATSM) and fluorine-18 2-fluoro-2-deoxyglucose (^<18>FDG) in mice bearing tumors of four different origins, LLC1, Meth-A, B16 and colon26, were compared to the immunohistochemical staining for proliferating cells (Ki67), blood vessels (CD34 or von Willebrand Factor(vWF)) and apoptotic cells (terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) method). With all the cell lines, ^<64>Cu-ATSM and ^<18>FDG were distributed to different regions of the tumor mass. The immunohistochemical study demonstrated that the high ^<64>Cu-ASTM uptake regions were hypovascular and consisted of tumor cells arrested in cell cycle, while the high ^<18>FGD uptake regions were hypervascular and consisted of proliferating cells. Through our study, it was revealed that one tumor mass contains two regions of different characteristics, which can be distinguished by ^<64>Cu-ATSM and ^<18>FDG. Since hypoxia and cell cycle arrest are critical factors to reduce the sensitivity of tumor to radiation and conventional chemotherapy, regions with such characteristics in tumor should be treated intensively as one of the primary targets. ^<64>Cu-ATSM which can delineate hypoxic and cell cycle arrested regions in tumors can provide valuable information for cancer treatment as well as the possibility to treat such regions directly as an internal radiotherapy reagent.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Basic characterization of Cu-64-ATSM as a radiotherapy agent.2005
Author(s)
A.Obata, S.Kasamatsu, J.S.Lewis, T.Furukawa, S.Takamatsu J.Toyohara, T.Asai, M.J.Welch, S.G.Adams, H.Saji, Y.Yonekura, Y.Fujibayashi
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Journal Title
Nuclear Medicine & Biology 32
Pages: 21-28
Description
「研究成果報告書概要(欧文)」より
Related Report
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