ESTABLISHMENT OF IMMUNOSUPPRRESIVE METHOD FOR CLINICAL DISCORDANT XENOGENEIC CARDIAC TRANSPLANTATION
| Project/Area Number |
14370412
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
FUKUSHIMA Norihide Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (30263247)
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| Co-Investigator(Kenkyū-buntansha) |
SAWA Yoshiki Osaka University, Hospital, Associate Professor, 医学部附属病院, 助教授 (00243220)
MATSUMIYA Goro Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (20314312)
SHIRAKURA Ryota Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00116047)
MIYAGAWA Shuji Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (90273648)
TAKANO Hiroshi Osaka University, Graduate School of Medicine, Lecturer, 医学系研究科, 講師 (70346196)
宮本 裕治 大阪大学, 医学系研究科, 講師 (80229898)
市川 肇 大阪大学, 医学系研究科, 助手 (60303939)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2003: ¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2002: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Keywords | Xenografts / Rhesus Monkey / Transgenic Pig / Hyper Acute Rejection / DAF / Immunoabsorption / 異種移植 / ブタ / 遺伝導入 / 補体制御因子 / decay accelerating factor / 臓器灌流 / 心臓移植 / 遺伝子導入 / decay acclerating factor / N-acetylglucosamiltransferase |
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| Research Abstract |
The hearts of transgenic pig (human DAF) and normal pig were transplanted orthotopically into rhesus monkey. No monkeys transplanted with normal pigs could weaned from cardiopulmonary bypass (CPB) and the grafts showed high grade hyperacute rejection (HAR). Mokeys transplanted with transgenic DAF pig hearts could be weaned from CPB and grafts did not show HAR, however all animals died within 7 hours after reperfusion. These data suggested DAF may extend xenograft survival, but not enough to make animal survive more that a day.
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Report
(3 results)
Research Products
(17 results)
