| Project/Area Number |
14370414
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | OITA UNIVERSITY |
|---|
Principal Investigator |
HADAMA Tetsuo Oita University, Faculty of Medicine, Professor, 医学部, 教授 (00145377)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKO Hidenori Oita University, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (20315344)
MIYAMOTO Shinji Oita University, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (70253797)
ANAI Hirofumi Oita University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (20291544)
HAMAMOTO Hirotsugu Oita University, Faculty of Medicine, Staff Doctor, 医学部, 医員
IWATA Eriko Oita University, Faculty of Medicine, Staff Doctor, 医学部, 医員
|
|---|
| Project Period (FY) |
2002 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 2003: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
|
|---|
| Keywords | Cardiopulmonary bypass / Continuous flow / Mixed-flow pump / Mixed-flow.pump |
|---|
| Research Abstract |
We performed a clinical evaluation and a basic research for long term use of a newly developed miniature mixed-flow blood pump (MFP) for cardiopulmonary bypass (CPB). In the clinical evaluation, 10 patients received a CPB with the MFP. The pump flow was maintained steadily. The MFP was controlled very smoothly at starting and weaning state. Changes in plasma free hemoglobin, lactate dehydrogenase, platelet count, β-thromboglobulin and thrombin-antithrombin complex showed no significant differences from those of a control pump. We believe the MFP had good controllability and less damage on the blood. Left ventricular bypasses were established in 7 goats to evaluate durability and antithrombogenesity. In two goats, experiments were finished after 14 days bypass. Thrombus formations were obtained around a bearing. We believe some improvements of bearings for long term use.
|
