• Search Research Projects
  • Search Researchers
  1. Back to previous page

Analysis of the brainstem neuronal network controlling laryngeal movements

Research Project

Project/Area Number14370538
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionChiba University

Principal Investigator

SHIBA Keisuke  Chiba University, University Hospital, Assistant, 医学部附属病院, 助手 (40291299)

Co-Investigator(Kenkyū-buntansha) UMEZAKI Toshiro  Kyushu University, Hospital, Lecturer, 附属病院, 講師 (80223600)
NAKAZAWA Ken  Chiba University, Graduate School of Medicine, Lecturer, 大学院・医学研究院, 講師 (10312943)
Project Period (FY) 2002 – 2003
Project Status Completed(Fiscal Year 2003)
Budget Amount *help
¥10,200,000 (Direct Cost : ¥10,200,000)
Fiscal Year 2003 : ¥4,000,000 (Direct Cost : ¥4,000,000)
Fiscal Year 2002 : ¥6,200,000 (Direct Cost : ¥6,200,000)
Keywordslarynx / thyroarytenoid muscle / multiple system atrophy / cat / laryngeal obstruction / 喉頭反射 / 多系統委縮症 / 嚥下 / せき / くしゃみ / 発声 / 咽頭 / 除脳ネコ
Research Abstract

1.We studied the patterns of membrane potential changes in vocal cord tensor motoneurons, i.e. cricothyroid muscle motoneurons (CTMs), during fictive breathing, vocalization, coughing, and swallowing in decerebrate paralyzed cats to determine the nature of central drives to CTMs during these behaviors. Our study revealed that the main role of the cricothyroid muscle is vocalization but the functional roles in coughing and swallowing are minor, and that the CTM activity during resting breathing and vocalization are primarily controlled by excitatory inputs, while during coughing and swallowing, inhibitory inputs play important roles in shaping membrane potential trajectories.
2.In patients with vocal cord abduction impairment, we investigated the role of the vocal cord adductor in generating dyspnea in laryngeal obstruction by recording its electromyographic activity and by observing vocal cord movement endoscopically under propofol anesthesia. The adductor was activated during inspirati … More on and the glottis was closed with laryngeal stridor. Because this adductor inspiratory activity was abolished by opening tracheostoma in tracheostomized patients, it is strongly suspected that this inspiratory adductor activity is induced by the airway reflex.
3.We hypothesized that an airway reflex attributable to insufficient opening of the glottis during inspiration causes this adductor inspiratory activity. To identify such airway reflex, we recorded the adductor electromyogram in the cat whose vocal cords were mechanically adducted under anesthesia. In these cats, the adductor was activated during inspiration with powerful negative pressure in the trachea. The adductor was activated by negative pressure in the subglottic space, but scarcely activated by in the lower airway. In addition, the adductor inspiratory activity in glottis-closed cats was usually abolished by laryngeal deafferentation. We conclude that the airway reflex triggered by subglottic negative pressure attributable to glottal narrowing during inspiration causes the adductor inspiratory activity similar to that in MSA patients. Less

Report

(3results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report

Research Products

(9results)

All Other

All Publications

  • [Publications] Shiba K, Isono S, Sekita Y, Tanaka A.: "Inspiratory activation of the vocal cord adductor, part I : human study in patients with restricted abduction of the vocal cords"Laryngoscope. 114. 372-375 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sekita Y, Shiba K, Nakazawa K, Numasawa T, Isono S.: "Inspiratory Activation of the Vocal Cord Adductor, Part II : Animal Study in the Cat"Laryngoscope. 114. 376-380 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Numasawa T, Shiba K, Nakazawa K, Umezaki T.: "Membrane potential changes in vocal cord tensor motoneurons during breathing, vocalization, coughing and swallowing in decerebrate cats"Neuroscience Research. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiba K, Isono S, Sekita Y, Tanaka A.: "Inspiratory activation of the vocal cord adductor, part I : human study in patients with restricted abduction of the vocal cords."Laryngoscope. 114. 372-375 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sekita Y, Shiba K, Nakazawa K, Numasawa T, Isono S.: "Inspiratory Activation of the Vocal Cord Adductor, Part II : Animal Study in the Cat."Laryngoscope. 114. 376-380 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Numasawa T, Shiba K, Nakazawa K, Umezaki T.: "Membrane potential changes in vocal cord tensor motoneurons during breathing, vocalization, coughing and swallowing in decerebrate cats."Neuroscience Research. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiba K, Isono S, Sekita Y, Tanaka A.: "Inspiratory activation of the vocal cord adductor, part I : human study in patients with restricted abduction of the vocal cords"Laryngoscope. 114. 372-375 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sekita Y, Shiba K, Nakazawa K, Numasawa T, Isono S.: "Inspiratory Activation of the Vocal Cord Adductor, Part II : Animal Study in the Cat"Laryngoscope. 114. 376-380 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Numasawa T, Shiba K, Nakazawa K, Umezaki T.: "Membrane potential changes in vocal cord tensor motoneurons during breathing, vocalization, coughing and swallowing in decerebrate cats"Neuroscience Research. (印刷中).

    • Related Report
      2003 Annual Research Report

URL :

Published : 2002-04-01   Modified : 2016-04-21  

Information FAQ News Terms of Use

Powered by NII kakenhi