| Project/Area Number |
14370626
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
KOYAMA Shigeto Tohoku University, Hospital, Lecturer, 歯学部附属病院, 講師 (10225089)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Makoto Tohoku University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (80091768)
INAI Tetsuji Tohoku University, Hospital, Lecturer, 歯学部附属病院, 講師 (60193538)
SASAKI Keiichi Tohoku University, Graduate School of Dentistry, Professor, 大学院・歯学研究科, 教授 (30178644)
YAMAGUCHI Keiichiro Tohoku University, Cyclotron Radioisotope Center, Assistant Professor, サイクロトロン・ラジオアイソトープセンター, 助手 (40210356)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2002: ¥7,500,000 (Direct Cost: ¥7,500,000)
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| Keywords | nuclear imaging / bone scintigraphy / turn-over of bone / dental implant / 骨 シンチグラフィ / 核医学イメージング / ラジオオートグラフィ |
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| Research Abstract |
Bone changes around the dental implants have not been fully elucidated. This study amid to reveal the dynamic change of bone metabolism around the implant using bone scintigraphy. Experimental implants were inserted in the tibiae of Wister rats. To observe the bone metabolic activity, bone scintigraphy of the cranium was taken using a gamma-camera with a modified high-resolution pinhole collimator (diameter of the pinhole: 2mm). 99mTc-MDP was injected intravenously (2 mCi/rat). Static planer acquisition in coronal direction was executed at 2 hours after the injection. The image takings were made at 4 days, 1, 2, 3, 4 weeks and 5 weeks after the implant insertion. After obtaining osseointegration, implants were loaded with coil springs (100,150,200g). The image takings were also made at 4 days, 1, 2, 3, 4 weeks and 5 weeks after loadings. Accumulation of 99mTc-MDP to the tibiae bone around the implant and the contralateral intact site were counted. Uptake ratio of the tibiae bone around the implant to the intact, site was calculated in each group. The study revealed that bone metabolism at, the implant site was returned to the same level as the contralateral intact site at Sweeks after the insertion. High peak accumulation of 99m-MDP was seen around the implant at from 7 to 12 days after insertion. Uptake ratio around the implant was differing among the different kind of loading. Furthermore, there was significant difference between the loading side and the traction side of implant after loading to implants. Turn-over of the tibiae bone around the dental implant was demonstrated with the active uptake of 99mTc-MDP by bone scintigraphy.
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