Change of the response of the periodontal ligament to mechanical stimulation with aging : from the aspect of the interrelation between microvasculature and the periodontal ligament cells
| Project/Area Number |
14370685
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Hokkaido University |
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Principal Investigator |
IIDA Junichiro Hokkaido University, Graduate School of Dental Medicine, Professor, 大学院・歯学研究科, 教授 (90151232)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMORI Osamu Nagoya City University, Medicine, Associate professor, 医学部, 助教授 (30128350)
INOUE Nobuo Hokkaido University, Graduate School of Dental Medicine, Professor, 大学院・歯学研究科, 教授 (20091415)
SATO Yoshiaki Hokkaido University, Graduate School of Dental Medicine, Associate professor, 大学院・歯学研究科, 助教授 (00250465)
KANEKO Tomoo Hokkaido University, Hokkaido University Hospital, Lecturer, 病院・講師 (10241340)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 2004: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2003: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Mechanical stimulation / Microvasculatore / Blood vessel / Leucocyte / Angiogenesis / Aging / Senescence / Perioral muscle / 口腔周囲軟組織 |
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| Research Abstract |
1.The purpose was to clarify the acute microvascular reaction to mechanical stimulation especially on the interrelation between endothelial cells and white blood cells.
Continuous and intermittent pressure stimulation was applied to post-capillary venule in the cheek pouch of golden hamsters. As a result, at the site just below the stimulation, rolling and adhering leukocytes especially monocytes were significantly increased.
2.The purpose was to clarify the long-term morphological changes of the microvasculator under the mechanical stimulation. Continuous and intermittent pressure stimulation was applied to the dorsal skin of a hamster using a dorsal skin chamber, and observed capillaries using intravital microscopy for 7days. As a result, strong increase in the permeability was observed under the continuous stimulation. Angiogenesis was detected during the observation, and the diameter of capillaries was doubled at 7 days under the intermittent stimulation.
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Report
(4 results)
Research Products
(14 results)
