| Project/Area Number |
14370781
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | Kumamoto University |
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Principal Investigator |
SAITO Hideyuki Kumamoto University, Hospital Pharmacy, Professor, 医学部附属病院, 教授 (40225727)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Akinobu Kumamoto University, Hospital Pharmacy, Lecturer, 医学部附属病院, 講師 (00322313)
MASUDA Satohiro Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (90303825)
FUKATSU Atsushi Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (90247685)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 2004: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | Drug transporter / Renal excretion / Renal tubular dysfunction / Nephrotoxicity / Dosage regimen / Renal failure / 尿細管分泌 / 有機アニオン / 有機カチオン / 投与設計 / アニオン性薬物 / カチオン性薬物 / 遺伝子発現 |
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| Research Abstract |
The proximal tubules of kidney play a pivotal role in limiting or preventing toxicity by secreting organic anions and cations into urine. Organic ion transporter family(SLC22A) appeared to mediate renal secretion of these molecules. Organic anion transporters, OAT-K1 and OAT-K2 could serve as multispecific transporters, mediating transport of a wide variety of endogenous substances and xenobiotics. The levels of urinary excretion of dmetidine was reduced under cronic renal failure(CRF) partiy due to the reduced expression of rOCT2, and the lowered plasma level of testosterone was suggested to be responsible for the depressed rOCT2 expression in CRF. hOAT3 was suggested to play an important role for anionic drug secretion in patients with renal diseases and that the expression levels of drug transporters may be related to the alteration of renal drug secretion.
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