| Project/Area Number |
14380008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
体育学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MATSUDA Mitsuo University of Tsukuba, Institute of Health and Sport Sciences, Professor, 体育科学系, 教授 (20110702)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Seiji University of Tsukuba, Institute of Health and Sport Sciences, Assistant Professor, 体育科学系, 講師 (30282346)
MIYAUCHI Takashi University of Tsukuba, Institute of Clinical Medicine, Professor, 臨床医学系, 教授 (60222329)
AJISAKA Ryuichi University of Tsukuba, Institute of Health and Sport Sciences, Associate Professor, 体育科学系, 助教授 (70151058)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2003: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2002: ¥7,900,000 (Direct Cost: ¥7,900,000)
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| Keywords | older human / elderly human / arterial compliance / physical activity / exercise training / vascular endothelial function / aorta / 運動トレーニンゲ |
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| Research Abstract |
The purpose of the present study was to investigate the effect of daily physical activity on systemic arterial compliance (SAC) in older humans. The products of this study are as follows. First, SAC might be a determinant of cardiorespiratory fitness (ventilatory threshold : VT), and meanwhile, endurance exercise training could improve both arterial compliance and VT in older humans. Second, an increase in daily physical activity could improve the age-induced reduction of arterial compliance and the age-related rise of systolic blood pressure in older humans. However, there was a limitation in the effect of physical activity on SAC, i.e., SAC might not exceed a certain level regardless of an increase in physical activity. Third, aerobic exercise training caused a decrease in plasma endothelin-1 (a potent vasoconstrictor peptide) level and an increased in plasma nitric oxide (a potent vasodilator substance) level (measured as nitrite/nitrate) in older humans. The gene and protein expression of endothelial NO synthase (eNOS) in the aorta of rat was decreased by aging, and the expression was increased by aerobic exercise training
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