| Project/Area Number |
14380389
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | IBARAKI UNIVERSITY |
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Principal Investigator |
MASUZAWA Toru IBARAKI Univ., College of Engineering, Professor, 工学部, 教授 (40199691)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Nobuatsu IBARAKI Univ., College of Engineering, Associate Professor, 工学部, 助教授 (30323207)
OSHIMA Ikuya IBARAKI Univ., College of Engineering, Assistant Professor, 工学部, 講師 (80007632)
YAMANE Takashi AIST, Human Science & Biomedical.Eng., Deputy Director, 人間福祉医工学研究部門, 副研究部門長 (10358278)
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| Project Period (FY) |
2002 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2004: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2003: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | Artificial heart / Blood copatibility / meso scale flow analysis / Flow analysis / Hemolysis / Flow visualization / Magnetically suspended blood pump |
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| Research Abstract |
Following studies were investigated to establish a mesoscopic flow analysis method to develop good biocompatible artificial hearts.
A new computational model based on three-dimensional two-way particle method was invented. Plasma fluid is discretized by SPH particles, and a red blood cell (RBC) is expressed by internal SPH particles surrounded by elastic membrane (structure) particles. For verifying the model, we numerically analyzed the three-dimensional tank-tread motion of an RBC under a constant shear field. The numerical results can well reproduce behaviors of RBC.
The microscopic quantitative flow visualization method, whose space resolution was 10 micro-meter order, was developed to investigate the flow field on the artificial heart surface. Micro flow in the gap between the inner and the outer cylinder of the rotational shear stressor was observed to clarify flow condition caused by the surface roughness variation on the inner cylinder. As a result, a small profile difference was
… More
observed in the circumferential velocity that was caused by the a few micrometer surface roughness variation. Although the turbulent intensity difference had been predicted caused by the surface roughness variation, remarkable turbulent intensity difference was hardly observed caused by a 'surface roughness variation.
Quantitative evaluation was carried out using a rotational shear stressor and fresh bovine blood to clarify the relationship between the surface roughness of artificial hearts and hemolysis level. A threshold of the roughness for a rapid increase in hemolysis was found to exist between Ra0.6 μm and Ra0.8 μm under a laminar shear flow condition of 3,750 s^<-1>. Magnetically suspended pumps were developed as a test tool for the hemocompatibility. Developed artificial hearts displayed sufficient pump performance. Maximum pressure head, flow rate are more than 200 mm Hg and 10L/min, respectively. Developed maglev pumps will be used as tools to investigated the relationship between hemolysis and surface roughness. Less
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