Development of anti-bacterial material included in cyclodextrin with environmentally controlled release characteristics
| Project/Area Number |
14550737
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
化学工学一般
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| Research Institution | Tottori University |
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Principal Investigator |
FURUTA Takeshi Tottori University, Faculty of Engineering, Professor, 工学部, 教授 (10026164)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHII Hidefumi Tottori University, Faculty of Engineering, Associate Professor, 工学部, 助教授 (60174885)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | MCT-β-CD / washi paper / antibacterial compound / release characteristics / hinokitiol |
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| Research Abstract |
In this research and development, we have studied the technique to make anti-bacterial material included in cyclodextrin in accordance with the environmental temperature and humidity.
1)Monochlorotriazinyl-β-cyclodextrin (MCT-β-CD) was covalently bonded to cellulose powder and washi paper. The amount of MCT-β-CD bonded to them was dependent on the water content, the reaction temperature and the concentration of MCT-β-CD of the solution. The reaction was characterized as a physical adsorption of the MCT-β-CD on the cellulose materials, followed by an appearing zero order chemical reaction.
2)The immobilized cyclodextrin was able to include and release hinokitiol as a model antibacterial flavor. The average molar inclusion ratio to MCT-β-CD was 0.85, which is nearly the same inclusion fraction as for hinokitiol in native β-cyclodextrin.
3)The release rates of hinokitiol included in the fixed MCT-β-CD were monitored at different relative humidities at 50℃ The release rates were markedly increased with the increase in the relative humidity. The release kinetic could be modeled using the Avrami equation. The hinokitiol included in the immobilized MCT-β-CD could be well controlled to release compared to that in the unbound MCT-β-CD.
4)To investigate the antibacterial ability of the hinokitiol containing washi paper, it was exposed to laboratory air, followed by a transfer of the accumulated vital microorganism to standard growth agar. The plate containing hinokitiol showed no microbial growth at all. The functional washi exhibited a good antibacterial ability.
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Report
(3 results)
Research Products
(13 results)
