|Budget Amount *help
¥3,500,000 (Direct Cost : ¥3,500,000)
Fiscal Year 2003 : ¥1,300,000 (Direct Cost : ¥1,300,000)
Fiscal Year 2002 : ¥2,200,000 (Direct Cost : ¥2,200,000)
We found out 13% of ocular adnexal lymphomas showed API2/MALTI. This abnormality was detected not only on MALT cases but a part of large-cell lymphoma. Moreover, API2IMALT 1 was found in 'a case which had no clonal expansion of immunoglobulin gene arrangement by PCR method. These findings are novel and were reported an article of Modern Pathology, 2003. In 2003, we analyzed MALT lymphomas of other organs. Forty-seven cases of colorectal MALT lymphomas were examined and revealed that 15% of them had this abnormality. Comparing between API2/MALTI positive and negative cases, there was no difference of the patients age, depth of lesions, multiplicity, macroscopic findings and IPI. But former ones were in higher clinicall staging and bigger in size, and male-doinance. Especially, positve cases were all in stage II or more, and this is statistically clearly higher than that of negative cases. This finding suggested that API2/MALTI is related to aggressive tumor growth, and it is important for selecting the rapeutic ways. This finding was also described in antother paper of Modern Pathology. We did not find this abnormality in thyroid or salivary gland MALT lymphomas. In these series, we incidentaly found that follicular lymphomas are often found in salivary cases. This point has been examined. About the SHPT expression, we analyzed methylation of this molecule and revealed 82% of MALT lymphomas, 93% DLBCL, 75% mantle cell lymphomas, 100% plasmacytoma, 96% follicular lymphomas. This is very intresting for histopathogenesis of lymphomas.