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Search for genes associated with genome copy number imbalance in human cancer

Research Project

Project/Area Number 14570147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionYamaguchi University

Principal Investigator

OGA Atsunori  Yamaguchi University, School of Medicine, Department of Pathology, Research Associate, 医学部, 助手 (90243633)

Project Period (FY) 2002 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsploidy / comparative genomic hybridization / aneuploidy / precancerous lesion / chromosome / CGH / genome / DNA / DNA aneuploidy / 20q13 / フローサイトメーター / tissue microarray / comparative genomic hybridizatio / genome / 固形癌 / 胃癌 / 増幅 / 欠失
Research Abstract

Many of human carcinomas show DNA aneuploidy with DNA index 1.3 or more. We think that this is one of basic feature of human carcinoma, however, little is known about the mechanism of acquisition of DNA aneuploidy. For detecting overall genome copy number aberration in detail and approaching to genes associated with the mechanism of acquisition of DNA aneuploidy, some carcinomas have been analyzed by comparative genomic hybridizations. The head investigator and other researchers (we) found and reported that a recurrent DNA copy number aberration (gain) at 18p in mucinous type colorectal carcinoma with DNA aneuploidy. Furthermore, we have reported that centrosome hyperamplification associated with DNA ploidy, 20q13, on which the Aurora-A gene is located, copy number increasing or tumor recurrence in bladder cancer. In addition to them, the head investigator took chances for publications about DNA aneuploidy in solid tumors and technical notes for DNA measurement with cytometer in Japanese. We have tried other experiments, for example, an experiment to induce DNA ploidy abnormality using cultured cell or to detect genome copy aberrations in precancerous lesions. We are preparing for publishing based on results from these experiments.

Report

(4 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • Research Products

    (22 results)

All 2005 2004 Other

All Journal Article (18 results) Book (1 results) Publications (3 results)

  • [Journal Article] 固形腫瘍のDNA解析2005

    • Author(s)
      小賀 厚徳 他
    • Journal Title

      Medical Technology 33

      Pages: 47-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA ploidy analyses of solid tumors2005

    • Author(s)
      Oga A, et al.
    • Journal Title

      Medical Technology (in Japanese) 33

      Pages: 47-52

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 固形腫瘍のDNA解析2005

    • Author(s)
      小賀 厚徳 他
    • Journal Title

      Medical Technology 33・1

      Pages: 47-52

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Centrosome hyperamplification predicts progression and tumor recurrence in bladder cancer2004

    • Author(s)
      Yamamoto Y., et al.
    • Journal Title

      Clinincal Cancer Research 10

      Pages: 6449-6455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multicolor FISH and cytometric analyses allow classification of urothelial carcinomas into two subtypes, low-and high-grade tumors2004

    • Author(s)
      Ikemoto K, et al.
    • Journal Title

      International Journal of Oncology 25

      Pages: 893-898

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Two subtypes of mucinous colorectal carcinoma characterized by laser scanning cytometry and comparative genomic hybridization2004

    • Author(s)
      Liu XP., et al.
    • Journal Title

      International Journal of Oncology 25

      Pages: 651-621

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] DNA sequence copy number aberrations in prostate cancers : a comparison of comparative genomic hybridization data between Japan and European countries2004

    • Author(s)
      Matsuda K., et al.
    • Journal Title

      Cancer Genetics and Cytogenetics 152

      Pages: 617-622

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Flow cytometerによるDNA量測定-PI染色、DNAヒストグラム解析、coefficient of variationを中心として-2004

    • Author(s)
      小賀 厚徳 他
    • Journal Title

      サイトメトリーリサーチ 14(2)

      Pages: 15-21

    • NAID

      10026899616

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Centrosome hyperamplification predicts progression an tumor recurrence in bladder cancer2004

    • Author(s)
      Yamamoto Y, et al.
    • Journal Title

      Clin Cancer Res. 10

      Pages: 6449-6455

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Multicolor FISH and cytometric analyses allow classification of urothelial carcinomas into two subtypes, low- and high- grade tumors.2004

    • Author(s)
      Ikemoto K, et al.
    • Journal Title

      Int J Oncol. 25

      Pages: 893-898

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Two subtypes of mucinous colorectal carcinoma characterized by laser scanning cytometry and comparative genomic hybridization.2004

    • Author(s)
      Liu XP, Sato T, et al.
    • Journal Title

      Int J Oncol. 25

      Pages: 615-621

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH.2004

    • Author(s)
      Hashimoto K, et al.
    • Journal Title

      Mod Pathol. 17

      Pages: 617-622

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Notes for DNA measurement of propidium iodide stained cells with flow cytometry2004

    • Author(s)
      Oga A, et al.
    • Journal Title

      Cytometry Research (in Japanese) 14(2)

      Pages: 15-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Flow CytometerによるDNA測定-PI染色、DNAヒストグラム、coefficient variationを中心として-2004

    • Author(s)
      小賀 厚徳 他
    • Journal Title

      サイトメトリーリサーチ 14・2

      Pages: 15-21

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ティッシュマイクロアレイによる医学・生物学的研究〜省エネ・省コスト、効率化をはかる〜2004

    • Author(s)
      小賀 厚徳 他
    • Journal Title

      バイオベンチャー 4・4

      Pages: 18-21

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Centrosome hyperamplification predicts progression and tumor recurrence in bladder cancer2004

    • Author(s)
      Yamamoto Y., et al.
    • Journal Title

      Clinical Cancer Research 10・19

      Pages: 6449-6455

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Multicolor FISH and cytometric analyses allow classification of urothelial carcinomas into two subtypes, low- and high-grade tumors2004

    • Author(s)
      Ikemoto K., et al.
    • Journal Title

      International Journal of Oncology 25・4

      Pages: 893-898

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Two subtypes of mucinous colorectal carcinoma characterized by laser scanning cytometry and comparative genomic hybridization2004

    • Author(s)
      Liu X.P., et al.
    • Journal Title

      International Journal of Oncology 25・3

      Pages: 615-621

    • Related Report
      2004 Annual Research Report
  • [Book] フローサイトメトリー自由自在(分担執筆 細胞周期)2004

    • Author(s)
      小賀 厚徳(分担執筆)
    • Publisher
      秀潤社
    • Related Report
      2004 Annual Research Report
  • [Publications] Arai H, et al.: "Detection of amplified oncogenes by genome DNA microarrays in human primary esophageal squamous cell carcinoma"Cancer Genetics and Cytogenetics. 146. 16-21 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ueno T, et al.: "Prediction of Nodal Metastasis by Comparative Genomic Hybridization in Biopsy Specimens from Patients with Superficial Esophageal SCC"Clinical Cancer Research. 9・14. 5137-5141 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] OGA atsunori: "New perspectives for tumor pathology provided by comparative genomic hybridization"International Journal of clinical Oncology. 7・(3). 133-137 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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