| Project/Area Number |
14570276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Chiba University |
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Principal Investigator |
TOKUHISA Takeshi Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (20134364)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Akemi Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (90359597)
ARIMA Masafumi Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (00202763)
HATANO Masahiko Chiba University, Gene Research Center, Associate Professor, 遺伝子実験施設, 助教授 (20208523)
岡田 誠治 熊本大学, エイズ学研究センター, 教授 (50282455)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Memory T cells / Transcription factor / BCL6 / Transgenic mice / Homeostatic proliferation / Central memory T cells / BAZF / CD8 T cells / CD8T細胞 / 好酸球性アレルギー / IL-5 / 転写抑制 / エフェクター細胞 |
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| Research Abstract |
Naive T cells proliferate and differentiate into memory cells after antigenic stimulation or in a lymphopenic environment. We showed here transient increases in memory phenotype CD8^+ T cell numbers in the lymphopenic environment of spleens of very young mice. The magnitude of the increase correlated with Bcl-6 expression in the T cells. Bcl-6 controlled the generation and maintenance of antigen-specific memory phenotype CD8^+ T cells in the spleens of immunized mice. These data suggest that Bcl-6, which is also essential for memory B cell development in germinal centers, is a key molecule for the establishment not only of memory T cells but also of the peripheral T cell compartment in infancy.
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