| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Research Abstract |
A clustering of abnormal glucose tolerance, hypertension and dyslipidemia has been, labeled as metabolic syndrome. Asians have a lower frequently of obesity than do Caucasians, but have an increasing tendency toward metabolic syndrome. Visceral, obesity has been proposed as the most important determinant of metabolic syndrome. Obesity is increasing rapidly in Asian countries and has become, a common health problem in Asia. Trp64Arg mutation in the β_3-adrenergic receptor (β_3AR) gene is relatively common in Japanese people. However, it has not been clear whether persons with Trp64Arg mutation, in the β_3AR gene tend to have obesity and difficulty in losing weight even with a restricted diet and exercise. We investigated the response of body weight and metabolic factors to behavioral intervention in Japanese women with Trp64Arg mutation in the β_3AR gene. Results of the present study suggest that the Trp64Arg mutation of the β_3AR gene is associated with difficulty in losing weight thro
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ugh the behavioral intervention, although it is not related to obesity-related phenotypes and resting energy expenditure before the intervention.
The prevalence of adult obesity, as BMI equal to or greater than 30.0, ranges from 10-25% in most Western Europe countries and 20-25% in the Americas. Graded increases in BMI groups were positively associated with the prevalence of metabolic syndrome. The "Overweight" Japanese had a significantly higher prevalence of metabolic syndrome, compared with "Normal" Japanese, in contrast to the "Overweight" in the other two ethnic groups, who did not. The present investigation suggests that metabolic syndrome is affected by BMI and may be affected by the metabolic component of the diet, which in turn may have some impact on metabolic syndrome in an ethnic specific manner. Accumulated evidence suggests that hypertriglyceridemia (HTG) is independently associated with an increased incidence of cardiovascular disease. The Japanese and Koreans had higher values for triglyceride than their Mongolian counterparts, despite lower BMI values for the Japanese and Koreans. The Japanese and Koreans ate fish more frequently and had remarkable higher-values for n-3 PUFA than did the Mongolians. Multiple regression analysis showed that, triglyceride levels had a great magnitude of correlation with increases in the 18:1/18:0 ratio for the Japanese and Mongolians, and n-3 PUFA remained significant for the Mongolians. HTG is ethnic specifically associated with an increase in the 18:1/18:0 ratio or a decrease in n-3 PUFA in plasma for the Japanese, Koreans and Mongolians. Less
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