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Fundamental study on the estimation of blood concentration of ethanol and its metabolites

Research Project

Project/Area Number 14570388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionYamaguchi University

Principal Investigator

FUJIMIYA Tatsuya  Yamaguchi University, School of Medicine, Professor, 医学部, 教授 (50219044)

Co-Investigator(Kenkyū-buntansha) OHBARA Yumiko  Yamaguchi University, School of Medicine, Research Associate, 医学部, 助手 (90079757)
Project Period (FY) 2002 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsAlcohol / Acetaldehyde / Acetate / Pharmacokinetics / Toxicokinetics / Drug kinetics / Metabolite / Individual difference / DNA多型
Research Abstract

In Japan, there are many flushers who have flushing reactions during alcohol drinking, since they accumulate acetaldehyde due to partial defect of activity of aldehyde dehydrogeuase (ALDH2). We examined the effects of blood ethanol level on the disposition of acetaldehyde and acetate with and without cyanamide treatment, which is the inhibitor of ALDH2. Rabbits were used. An ethanol saline solution was administered intravenously into these rabbits at 1.0 or 2.0 g/kgBW for 20 minutes, followed by constant-rate infusion (0.25 g/kg/hr). At 4 and 8hr, the infusion rate was increased to 0.5 g/kg/hr for 1 hr. Blood ethanol, acetaldehyde and acetate concentrations were measured by headspace gas chromatography. We found that blood ethanol concentration reaches a steady state within 2 hours. The blood acetaldehyde concentration exhibited a spike-like increase in response to increases in the blood ethanol level, reaching a steady state around 1 hr after the increase. The change in concentration was in proportion to blood ethanol concentration, suggesting that acetaldehyde toxicity may increase with ethanol amount. We also found that blood acetate concentration reaches a steady state within 2 hr of administration. Blood acetaldehyde increased by the cyanamide treatment. The acetate level was constant, and its profile was hardly influenced by increases in the blood ethanol level. Our results indicate that the kinetic nature of acetaldehyde is different to that of acetate

Report

(3 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 品川 裕美: "アセトアルデヒド及び酢酸のアルコール点滴静注時の血中動態に関する検討"アルコールと医学生物学. 22. 46-49 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 田辺 充式: "アルコール点滴静注時のシアナマイドによるアルコールとその代謝産物の血中動態への影響"アルコールと医学生物学. 23. 141-145 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 大洞 弓子: "血中アルコールおよびアセトアルデヒド測定法とその留意点"臨床検査. 47. 627-631 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimiya, Tatsuya: "Pharmacokinetic study of ethanol and its metabolites during ethanol infusion."Legal Medicine. 5S1. S126-S128 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimiya, Tatsuya: "Pharmacokinetic study of ethanol and its metabolites in culture cells."Legal Medicine. 5S1. S123-S125 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shinagawa, H, Ohbara, Y, Aki, T, Fujimiya, T: "Pharmacokinetics of ethanol and its metabolites during ethanol infusion"Alcohol and biomedical science. 22. 46-49 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimiya T., Shinagawa H., Ohbora Y., Aki T.: "Pharmacokinetic study of ethanol and its metabolites in culture cells"Legal Medicine.. 5 Suppl 1. S123-S125 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujimiya T, Ohbora Y, Shinagawa H, Aki T.: "Pharmacokinetic study of ethanol and its metabolites during ethanol infusion"Legal Medicine.. 5 Suppl 1. S126-S128 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ohbora, Y, Fujimiya, T: "Method of Measurement of blood ethanol and acetaldehyde"Laboratory medicine. 47. 627-631 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanabe, M, Ohbora, Y, Fujimiya T: "Effects of cyanamide on disposition of blood ethanol and its metabolites"Alcohol and biomedical science. 23. 141-145 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 田辺充式: "アルコール点滴静注時のシアナマイドによるアルコールとその代謝産物の血中動態への影響"アルコールと医学生物学. 23. 141-145 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 大洞弓子: "血中アルコールおよびアセトアルデヒド測定法とその留意点"臨床検査. 47・6. 627-631 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 品川裕美, 大洞弓子, 藤宮龍也 他: "アセトアルデヒド及び酢酸のアルコール点滴静注時の血中動態に関する検討"アルコールと医学生物学. 22. 46-49 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2002-04-01   Modified: 2016-04-21  

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