Analysis of Prostanoid receptor subtypes in interstitial pneumonitis

• Project/Area Number: 14570427
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 内科学一般
• Research Institution: Kitasato University
• Principal Investigator: ENDO Hirahito Kitasato University, School of Medicine, Associate professor, 医学部, 助教授 (20213598)
• Co-Investigator(Kenkyū-buntansha): TANAKA Sumiaki Kitasato University, School of Medicine, Assistant professor, 医学部, 講師 (80265595) ; YOSHIDA Hide Kitasato university, School of Medicine, Research Associate, 医学部, 助手 (60327377) ; 内山 真主美 北里大学, 医学部, 助手 (40296447)
• Project Period (FY): 2002 – 2005
• Project Status: Completed (Fiscal Year 2005)
• Budget Amount: ¥3,200,000 (Direct Cost: ¥3,200,000); Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2002: ¥800,000 (Direct Cost: ¥800,000)
• Keywords: interstitial pneumonitis / bleomycin / 15 deoxy-prostaglandin J2 / Lipoxin / Thromboxane / Scleroderma / Leukotriene / ロイトリエン / プロスタグランジン / プロスタグランジン受容体 / PPARγ / プロスタクランジンE_2 / プロスタブランジンE受容体

Research Abstract

1.15 deoxy-prostaglandin J2 (15d-PGJ2) suppress mouse interstitial pneumonitis induced bleomycin. 15d-PGJ2 is a legand of nuclear receptor, peroxysome-proliferator activated receptor gamma. PPAR gamma highly expressed in lung lesion of bleomycin-induced interstitial pneumonitis
15d-PGJ2 is a stable metabolite of PGD2. PGD syntase retrovirally transfected fibroblasts also inhibited interstitial pneumonitis.
2.15d-PGJ2 inhibited skin sclerosis and lung fibrosis in bleomycin-induced mouse scleroderma model. In this disease model mast cells highly infiltrated in skin and lung and plasma histamine levels increased in this model. 15-dPGJ2 inhibited mast cell activation, histamine release.
3.Lipoxin A4 receptor (ALX) increased bleomycin-induced interstitial pneumonitis. Lipoxin A4 inhibited TGF beta induced lung fibroblast proliferation and collagen synthesis. And TXA2 receptor also induced in induced. ALX induced by TX syntase inhibitor.

Research Products

• [Journal Article] Inhibition of skin sclerosis by 15deoxy Delta(12,14)prostaglandinJ2 and retrovillary transfected prostaglandin D syntase in bleomycin induced mouse scleroderma. (2006)
  • Author(s): Kohno, Endo, H. et al.
  • Journal Title: Biomed Pharmacotherapy 60 Pages: 18-25
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. (2006)
  • Author(s): Murakami Y, Akahoshi T, Hayashi I, Endo H,. et al.
  • Journal Title: Arthritis Rheum. 54(2) Pages: 455-465
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibition of skin sclerosis by 15deoxy Delta(12,14)-prostaglandin J(2) and retrovirally transfected prostaglandin D synthase in a mouse model of bleomycin-induced scleroderma. (2006)
  • Author(s): Kohno, S., Endo, H., Hayashi, I., Murakami, Y., Kitasato, H., Kawai, S., Kondo, H
  • Journal Title: Biomed Pharmacotherapy, 60 Pages: 18-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of Triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals, (2006)
  • Author(s): Murakami, Y, Akahoshi, T, Hayashi, I, Endo, H, Kondo, H, Kawai, S, Inoue M, Kitasato H
  • Journal Title: Arthritis Rheum, 54 Pages: 455-462
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of skin sclerosis by 15deoxy Delta(12,14)prostaglandin J2 and retrovillary transfected prostaglandin D syntase in bleomycin induced mouse scleroderma. (2006)
  • Author(s): Kohno, S., Endo, H.et al.
  • Journal Title: Biomed Pharmachotherapy 60 Pages: 18-25
• [Journal Article] Regulatory expression of Lipoxin A4 receptor in physiologically estrus cycle and pathologically endometriosis (2005)
  • Author(s): Motohashi, E., Endo, E., et al.
  • Journal Title: Biomed Pharmacotherapy 59 Pages: 330-338
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 骨導補聴器の装用効果の推定(第2報) (2005)
  • Author(s): 松平登志正, 他5名
  • Journal Title: Sudiology Japan 48巻5号 Pages: 541-542
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Regulatory expression of lipoxin A4 receptor inphysiologically estrus cycle and pathologicallyendometriosis. (2005)
  • Author(s): Motohashi, E., Kawauchi, H, Endo, H, Kondo H, Kitasato, H., Kuramoto, H., Majoma, M., Ueno, N., Hayashi, I.
  • Journal Title: Biomed Pharmacotherapy, 59 Pages: 330-338
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Regulatory expression of Lipoxin A4 receptor in physiologically estrus cycle and pathologically endometriosis (2005)
  • Author(s): Motohashi, E., Endo, H.et al.
  • Journal Title: Biomed Pharmachotherapy 59 Pages: 330-338
• [Journal Article] Down-regulation of Lipoxin A4 receptor by thromboxane A2 signalinginRAW264.7 cells in vitro and bleomycin-induced lung fibrosis (2004)
  • Author(s): Sato, Y., Endo, H.et al.
  • Journal Title: Biomed Pharmacotherapy 58 Pages: 381-387
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Host stromal bradykinin B2 receptor signaling facilitates tumor-associated angiogenesis and tumor growth. (2004)
  • Author(s): Ikeda Y, Hayashi I, Kamoshita E, Yamazaki A, Endo H,. et al.
  • Journal Title: Cancer Res. 64(15) Pages: 5178-85
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 骨導語音聴覚検査の基準レベルの検討 (2004)
  • Author(s): 松平登志正, 他3名
  • Journal Title: Audiology Japan 47巻4号 Pages: 228-233
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Down-regulation of Lipoxin A4 receptor by thromboxan A2 signaling in RAW264.7 cells in vitro and bleomycin-induced lung fibrosis (2004)
  • Author(s): Sato Y., Kitasato H., Murakami Y., Hashimoto A, Endo H, Hirobumi K, Inoue M, Hayashi I.
  • Journal Title: Biomed pharmtherapy 58 Pages: 381-387
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Host Stromal Bradykinin B2 receptor Signaling facilitates Tumor- Associated angiogenesis and Tumor growth. (2004)
  • Author(s): Ikeda.Y.Hayashi, I, Kamoshita, E, Yamazaki, Endo, H.Ishihara, K., Yamashina, S.Tsutsumi, Y., Matsubara, H.Majima
  • Journal Title: Cancer Res 64(15) Pages: 5178-5185
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Down-regulation of Lipoxin A4 receptor by thromboxan A2 signaling in RAW264.7 cells in vitro and bleomycin-induc (2004)
  • Author(s): Sato, Y.EndoH, et al.
  • Journal Title: Biomedicin pharmtherapy 58 Pages: 381-387
• [Journal Article] Retrovirally introduced prostaglandin D2 syntase suppresses lung injury induced by bleomycin (2003)
  • Author(s): Ando, M., Endo, H.et al.
  • Journal Title: Am J Resp cell Mol Biol 28 Pages: 582-591
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differentiation expression of leukotriene B4 receptor subtype(BLT1 and BLT2) in human synovial tissues. (2003)
  • Author(s): Hashimoto, A., Endo, H.et al.
  • Journal Title: J. Rheum 30 Pages: 1712-1718
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. (2003)
  • Author(s): Ando M, Murakami Y, Kojima F, Endo H, Kitasato H, Hashimoto A, Kobayashi H, Majima M, Inoue M, Kondo H, Kawai S, Hayashi I.
  • Journal Title: Am J Respir Cell Mol Biol. 28(5) Pages: 582-591
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differentiation expression of Lekotriene B4 receptor subtype(BLT1 and BLT2) in human synobial tissues. (2003)
  • Author(s): Hashimoto A., Endo H., et al.
  • Journal Title: J.Rheum. 30 Pages: 1712-1718
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Retrovirally introduced prostagrandin D2 syntase suppresses lung injury induced by bleomycin. (2003)
  • Author(s): Ando, M, Endo, H et al.
  • Journal Title: Am J Respr cell Moe Biol 28 Pages: 582-591
• [Journal Article] Differential expression of leukotoriene B4 Receptor subtype (BLT1 and BLT2) in human synovial tissues (2003)
  • Author(s): Hashimoto.A.Endo, H et al.
  • Journal Title: J.Rheum 30 Pages: 1712-1718
• [Publications] Amano H, Endo H et al.: "Host prostaglandin E_2・EP3 signaling regulates Tumor-associated angiogenesis and tumor growth"J.Exp Med. 20. 221-232 (2003)
• [Publications] Hashimoto A, Endo H et al.: "Differential Expression of Leukotriene B_4 receptor Subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of potients with rheumatoid arthritis"J.Rheum.. 30. 1712-1718 (2003)
• [Publications] Ando M, Endo H et al.: "Rervovirally introduced prostaglandin D_2 synthase suppresses lung injury induced by bleomycin"Am.J.Respir.Cell Mol.Biol.. 28. 582-591 (2003)
• [Publications] Murakami Y, Endo H et al.: "Inhibition of Monosodium Urate Mono hydrate Crystal-Induced Acute Inflammation"Arthritis Rheum. 48. 2931-2941 (2003)
• [Publications] 遠藤平仁: "消化管にみられる線維症と治療"現代医療. 35・2. 117-121 (2003)