| Project/Area Number |
14570475
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi University |
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Principal Investigator |
AKISAWA Naoaki Kochi Medical School, Department of Gastroenterology and Hepatology, Research Associate, 医学部附属病院, 助手 (00322280)
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| Co-Investigator(Kenkyū-buntansha) |
SAIBARA Toshiji Kochi Medical School, Department of Gastroenterology and Hepatology, Assistant Professor, 医学部, 助教授 (60145125)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | NASH / HEPATIC STEATOSIS / INSULIN RESISTANCE / MOUSE / 高脂血症 / 肝細胞癌 / マイクロサテライト |
|---|
| Research Abstract |
Fatty liver has been a well-established reversible complication related to obesity. Recently, however, it was revealed to be a risk factor for developing non-alcoholic steatohepatitis(NASH), a novel type of life-style related disease. In addition, a considerable proportion of patients suffering from this new category of chronic liver disease was revealed to develop liver cirrhosis and hepatocellular carcinoma. NASH could be a serious social problem in Japan since 20 to 30 percent of adults are suffering from fatty liver today.
For this reason, we heed to deal with this life-style related disease. Very little facts are known about this novel disease and we need appropriate animal models of this disease to develop efficient therapeutic strategy. Therefore, we developed a model strain in mice of NASH and characterized its genetic predisposition in this study.
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