A molecular biological study on pathogenesis of esophago-gastric varices in patients with cirrhosis and approach to developing novel treatment
| Project/Area Number |
14570529
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
SOHDA Tetsuro Fukuoka University, Hospital, Lecturer, 病院, 講師 (30289532)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Masanori Fukuoka University, Hospital, Assistant Professor, 病院・助手 (20341448)
|
|---|
| Project Period (FY) |
2002 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
|
|---|
| Keywords | Liver cirrhosis / Nitric oxide(NO) / Vascular endothelial growth factor / Esophago-gastric varices / Ascites / VEGF / 肝硬変 / 門脈圧亢進症 / 急性肝障害 / マウス / 劇症肝炎 / VEGF遺伝子型 / nitric oxide (NO) / 急性肝炎 / 血管内皮細胞増殖因子(VEGF) |
|---|
| Research Abstract |
We have studied the pathogenesis of esophago-gastric varices in patients with cirrhosis. Especially, we have paid attention to importance of nitric oxide(NO) and vascular endothelial growth factor(VEGF), molecules associated with vasodilation, and their genornic polymorphism.
Esophago-gastric varices and endothelial NO synthase(eNOS) :
In the genotype analysis of E298D at eNOS gene, 44 of 54 patients showed a genotype Glu/Glu, and 10 showed Glu/Asp. The Asp/Asp genotype was not observed. There were no significant differences in the frequencies and size of esophago-gastric varices. However, serum nitrate levels were lower in the patients who have Glu/Asp genotype.
Esophago-gastric varices and VEGF :
The frequency of VEGF gene mutation (genotype C/T and T/T in 3'-UTR 936 polymorphism) in patients with esophago-gastric varices was lower than other patients. Moreover, we showed that cirrhotic patients with mutation genes in eNOS or VEGF have significantly lower risk for esophago-gastric varices.
Novel treatment for esophago-gastric varices :
Increased portal pressure after EVL may causes recurrence of esophago-gastric varices and ascites formation, and is thought to be associated VEGF genotypes. We also demonstrated the significance of VEGF genotype on ascites formation in cirrhotic patients. These results indicate that anti-VEGF therapy may be effective for prevention of esophago-gastric varices in cirrhotic patients with C/C in VEGF genotype.
|
Report
(4 results)
Research Products
(12 results)
-
-
-
-
-
-
[Journal Article] Hepatocellular carcinoma in a patient with liver cirrhosis associated with negative serum HCV tests but positive liver tissue HCV RNA.2004
Author(s)
Esaki T, Suzuki N, Yokoyama K, Iwata K, Irie M, Anan A, Nakane H, Yoshikane M, Nishizawa S, Ueda S, Sohda T, Watanabe H, Sakisaka S.
-
Journal Title
Intern Med. 43(4)
Pages: 279-282
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
-
[Journal Article] A case of rapid-onset primary biliary cirrhosis which resembled drug-induces liver injury.
Author(s)
Sohda T, Shiga H, Nakane H, Nishizawa S, Yoshikane M, Anan A, Suzuki N, Irie M, Iwata K, Watanabe H, Sakisaka S.
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
Related Report
-
