| Project/Area Number |
14570573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | National Kinki-Chuo Hospital for Chest Diseases, Clinical Research Center |
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Principal Investigator |
INOUE Yoshikazu National Kinki-Chuo Hospital for Chest Diseases, Clinical Research Center, department of Diffuse Lung Diseases and Respiratory Failure, Director, M.D.and Ph.D., 呼吸不全研究部長 (90240895)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Koh National International Medical Center, Research Institute, M.D., Ph.D., 国立国際医療センター研究所・呼吸器疾患研究部, 細菌性呼吸器疾患研究室長・現教授 (80207802)
OKADA Masaji National Kinki-Chuo Hospital for Chest Diseases, Clinical Research Center, Director, M.D.and Ph.D., 結核研究部長 (40160684)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | mast cells / fibroblasts / interstitial pneumonia / remodeling / MMP / bFGF / Flg / Bek / Tryptase / MMP-2 / 特発性間質性肺炎 / 肺リンパ脈管筋腫 / 肺線維症 |
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| Research Abstract |
Mast cells are supposed to have important roles in tissue remodeling, angiogenesis, and fibrosis. In the lungs with pulmonary fibrosis, such as idiopathic pulmonary fibrosis, the number of basic fibroblast growth factor (bFGF) expressing mast cells (MCs) increases in the lungs with idiopathic pulmonary fibrosis (IPF), reflecting degree of fibrosis. In the fibrotic lungs, α-smooth muscle actin (SMA) positive myofibroblasts, type II pneumocytes, alveolar macrophages increased, and that those cells expressed the receptors of bFGF, such as Flg (FGFR1) and Bek (FGFR2). Mast cells may affect fibroproliferative response in IPF, suggesting bFGF may have roles in the fibtroproliferative responce. Interestingly, mast cells and fibroblats work together in the tissue remodelling, controlling the amount of bFGF, matrix metalloproteinases, tryptase, and collagen deposition, in vitro model.
We conclude mast cells and fibroblasts have important roles in the tissue remodelling in the pulmonary fibrosis.
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