Development of novel contrast agents combined by block coplolymers to detect unstable atherosclerotic plaques
| Project/Area Number |
14570643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KANEKO Eiji Tokyo Medical and Dental University Hospital, Geriatrics, Assistant, 医学部附属病院, 助手 (10302853)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOKADO Kentaro Tokyo Medical and Dental University, Vascular Medicine, Professor, 大学院・医歯学総合研究科, 教授 (30192115)
KATAOKA Kazunori University of Tokyo, Materials Science, Professor, 大学院工学系研究科, 教授 (00130245)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | arteriosclerosis / atherosclerosis / unstable plaque / magnetic resonance imaging / MRI / iron / contrast agent / block copolymer / ガドリニウム |
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| Research Abstract |
(Background and purpose) Assembled block copolymers with a neutral surface charge escape from clearance by the reticuloendothelial system, have a longer half-life in blood, and are concentrated selectively in tissues with increased permeability when administered intravenously. To detect vascular lesions with increased permeability, we developed a new MRI contrast agent using block copolymer.
(Methods and Results) Spindle-shaped iron colloid particles are coated with block copolymers composed of polyethylene glycol and polyamino acid. The agent showed the mean hydrodynamic diameter similar to that of ferumoxides (Feridex R) (90 nm), and similarly shortened T2/T2* relaxation process greater than T1 relaxation process when dissolved in distilled water in small vials. An equivalent amount (0.56 mg Fe/kg) of this agent or ferumoxides was injected into the tail veins of rats that had the left carotid arteries injured with 2F embolectomy catheters. MRI images were obtained with Varian INOVA200 (4.7T) 10 min,1,2,3,4,6 and 24 h after injection. The novel contrast agent enhanced T2- weighted MR images of injured arteries 24 h after injection, while ferumoxides did not enhance it at any time points.
(Conclusions) A novel iron contrast agent combined by block copolymers enhances the image of denuded lesions of rat arteries. It may be useful to detect unstable plaques with increased permeability.
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Report
(3 results)
Research Products
(5 results)
