• Search Research Projects
  • Search Researchers
  1. Back to previous page

Analysis of expression of new prognostic factor run23-HI gene in non-Hodgkin's lymphoma

Research Project

Project/Area Number14570995
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKitasato University

Principal Investigator

NIITU Nozomi  Kitasato Univ., School of Medicine, Assistant Professor, 医学部, 講師 (20256697)

Project Period (FY) 2002 – 2004
Project Status Completed(Fiscal Year 2004)
Budget Amount *help
¥3,600,000 (Direct Cost : ¥3,600,000)
Fiscal Year 2004 : ¥900,000 (Direct Cost : ¥900,000)
Fiscal Year 2003 : ¥1,400,000 (Direct Cost : ¥1,400,000)
Fiscal Year 2002 : ¥1,300,000 (Direct Cost : ¥1,300,000)
KeywordsNon-Hodgkin's lymphoma / Serum nm23-H1 / ELISA / Cytoplasmic nm23-H1 / Immunohistochemistry / 免疫組織化学染色 / 非ホジキンリンパ膜 / 予後因子 / 悪性リンパ腫 / 細胞表面nm23-H1
Research Abstract

Recently, we established an ELISA technique for measuring nm23-H1 protein in serum, and found that the serum nm23-H1 level is a potential prognostic factor for patients with non-Hodgkin's lymphoma. We used immunohistochemistry to examine the expression of nm23-H1 by the lymphoma cells in patients with diffuse large B-cell lymphoma (DLBCL) or peripheral T-cell lymphoma (PTCL). By analyzing a consecutive series of 172 untreated DLBCL patients, 100 (58.1%) were strongly positive. The cytoplasmic nm23 expression in lymphoma cells correlated significantly with the serum nm23-H1 level. There was a significant correlation between patients with cytoplasmic nm23-positive lymphoma and those with PS 2-4, stage III/IV, bulky mass, B symptoms, elevated serum level of sIL-2R, and elevated serum level of CRP. Overall and progression-free survival rates were significantly lower in patients with nm23-H1-positive lymphomas than in those with nm23-H1-negative lymphomas. Similar difference was seen betwee … More n patients with high and low serum levels of nm23-H1. Thus, the correlation between presence or absence of cytoplasmic nm23-H1 expression and serum nm23-H1 levels suggests that serum nm23-H1 is produced directly by lymphoma cells. Expression of nm23-H1, TIA-1 or granzyme B was examined by immunohistochemistry in 137 previously untreated patients with the lymphoma. The relationship between the results and clinical outcome was examined in 81 patients with angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, or peripheral T-cell lymphoma-unspecified. It was found that nm23-H1 was produced by the neoplastic cells of some of the lymphoma and the expression rates of nm-23-H1, TIA-1, and granzyme B were 36.5%, 78.8%, and 32.8%, respectively. nm23-H1-positive or TIA-1-positive group had significantly shorter overall and disease-free survivals. Furthermore, a multivariate analysis confirmed the nm23-H1 expression to be an independent prognostic factor.
Because of nm23-HI production by lymphoma cells, we expect to see the development of new treatments targeting nm23 overexpression. Furthermore, the nm23-H1 protein can be an important prognostic factor in the above types of lymphoma. Less

Report

(4results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report

Research Products

(20results)

All 2004 2003 2002 Other

All Journal Article Publications

  • [Journal Article] Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma.2004

    • Author(s)
      Niitsu N, et al.
    • Journal Title

      Clin Cancer Res 10

      Pages : 2482-2490

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma.2004

    • Author(s)
      Niitsu, N., Nakamine, H., Okamoto, M., Akamatsu, H., Higashihara, M., Honma, Y., Okabe-Kado, J., Hirano, M.
    • Journal Title

      Clin Cancer Res. 10

      Pages : 2482-2490

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical significance of nm23-H1 proteins expressed on cell surface in non-Hodgkin's lymphoma2003

    • Author(s)
      Niitsu N, et al.
    • Journal Title

      Leukemia 17

      Pages : 196-202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Serum levels of the nm23-H1 protein and their clinical implication in extranodal NK/T-cell lymphoma.2003

    • Author(s)
      Niitsu N, et al.
    • Journal Title

      Leukemia 17

      Pages : 987-990

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma.2003

    • Author(s)
      Niitsu N, et al.
    • Journal Title

      Br J Haematol 123

      Pages : 621-630

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Clinical significance of nm23-H1 proteins expressed on cell surface in non-Hodgkin's lymphoma.2003

    • Author(s)
      Niitsu, N., Honma, Y., Iijima, K., Takagi, T., Higashihara, M., Sawada, U., Okabe-Kado, J.
    • Journal Title

      Leukemia 17

      Pages : 196202-196202

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Serum levels of the nm23-H1 protein and their clinical implication in extranodal NK/T cell lymphoma.2003

    • Author(s)
      Niitsu, N., Okamoto, M., Honma, Y., Nakamine, H., Tamaru, J.I., Nakamura, S., Yoshino, T., Higashihara, M., Hirano, M., Okabe-Kado, J.
    • Journal Title

      Leukemia 17

      Pages : 987-990

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma.2003

    • Author(s)
      Niitsu, N., Nakamine, H., Okamoto, M., Akamatsu, H., Honma, Y., Higashihara, M., Okabe-Kado, J., Hirano, M.
    • Journal Title

      Br J Haematol 123

      Pages : 621-630

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] High serum soluble CD44 is correlated with a poor outcome of aggressive non-Hodgkin's lymphoma.2002

    • Author(s)
      Niitsu N, Iijima K.
    • Journal Title

      Leuk Res 26

      Pages : 241-248

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Simultaneous elevation of the serum concentrations of vascular endothelial growth factor and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma.2002

    • Author(s)
      Niitsu N, et al.
    • Journal Title

      Eur J Haematol 68

      Pages : 91-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] High serum soluble CD44 is correlated with a poor outcome of aggressive non-Hodgkin's lymphoma.2002

    • Author(s)
      Niitsu, N., Iijima, K.
    • Journal Title

      Leuk Res 26

      Pages : 241-248

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Simultaneous elevation of the serum concentrations of vascular endothelial growth factor and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma.2002

    • Author(s)
      Niitsu, N., Okamoto, M., Nakamine, H., Yoshino, T., Tamaru, J-I., Nakamura, S., Higashihara, M., Hirano, M.
    • Journal Title

      Eur J Haematol 68

      Pages : 91-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] NIITSU N et al.: "Serum levels of the nm23-H1 protein and their clinical implication in extranodal NK/T-cell lymphoma."Leukemia. 17(5). 987-990 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] NIITSU N et al.: "Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma."Brithish J of Haematolosy. 123(4). 621-630 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] NIITSU N et al.: "Clinical significance of nm23-H1 proteins expressed on cell surface in non-Hodgkin's lymphoma."Leukemia. 17. 196-202 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 新津 望: "生物学的予後因子の臨床的意義-血清および細胞表面 nm23-H1蛋白の検討を中心に-"臨床血液学会誌. 44. 211-218 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] NIITSU N. et al.: "Clinical significance of nm23-H1 proteins expressed on cell surface in non-Hodgkin's Lymphoma"Leukemis. 17. 196-202 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] NIITSU N. et al.: "Simultaneous elevation of the serum concentrations of vascular endothelial growth factor and interleukin-6 as independent predictors of prognosis in aggressive non-Hodgkin's lymphoma"Eur. J. Haematolosy. 68. 91-100 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] NIITSU N. et al.: "Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-r"Leuk. Res. 26. 745-755 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] NIITSU N. et al.: "The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells. Candidate drugs for chemo-differentiation therapy against acutepromyelocytic leukemia"Exp. Hemato. 30. 1273-1282 (2002)

    • Related Report
      2002 Annual Research Report

URL :

Published : 2002-04-01   Modified : 2016-04-21  

Information FAQ News Terms of Use

Powered by NII kakenhi