| Project/Area Number |
14571069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAGAYAMA Yuji Nagasaki University, Graduate School of Biomedical Sciences Atomic Bomb Disease Institute Department of Medical Gene Technology, Professor, 大学院・医歯薬学総合研究科, 教授 (30274632)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Thyroid autoimmunity / TSH receptor / adenovirus / Autoantibody / Graves' disease / サトカイン / サイトカイン |
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| Research Abstract |
(1)The effect of genetic background on development of Graves' hyperthyroidism : we found that non-MHC genes, but not MHC, play a major role in development of Graves' hyperthyroidism in our mouse model.
(2)The effect of environmental factors : Neither environmental. microorganisms nor bacterial/yeast components appear to be involved in the pathogenesis of disease.
(3)The effect of Th1/Th2 balance of anti-TSH receptor immune response: Th2-immune deviation at the time of antigen-presentation by co-injection of adenovirus expressing interleukin-4, Schistosoma mansoni infection or administration of a-galactosylceremaide prevent Graves' disease induction. However, anti-TSHR immune response is once activated, Th2-immune polarization has little effect on disease course, indicating this type of immune manipulation may be just preventive, not therapeutic.
(4)Analysis of the epitopes on TSH receptor : N-terminus of TSH receptor extracellular domain is the major epitopes, for anti-TSH receptor antibodies recognizing conformational or linear epitopes.
(5)The effect of B cell deletion : Existence of normal B cell. population is essential for establishment of anti-TSH receptor memory T lymphocytes.
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