| Project/Area Number |
14571218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KIMURA Akio Kyoto Prefectural University of Medicine, department of medicine, Assistant, 医学研究科, 助手 (40305602)
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| Co-Investigator(Kenkyū-buntansha) |
OCHIAI Toshiya Kyoto Prefectural University of Medicine, department of medicine, Assistant, 医学研究科, 助手 (30311913)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | peritonitis carcinomatosa / hyper-thermia therapy / eicosapentaenoic acid / microsheres / マイクロスフェアー |
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| Research Abstract |
We already confirmed that chemotherapy using 5-FU suppository, contained poly-unsaturated fatty acid, had the tumorcidal effect with hyper-thermo therapy and radiation therapy at local recurrent of rectal cancer. In this project, we planed that we would develop microsheres contained poly-unsaturated fatty acid, this fatty acid made Free-Radical material affected by hyperthermia, and we would apply for the hyper-thermo-chemo-therapy at the peritonitis carcinomatosa with advance rectal cancer.
The eicosapentaenoic acid is poly-unsaturated fatty acid. And it calls Omega-3 fatty acid (or n-3 poly-unsaturated fatty acid). It has preventation of a thrombosis, it is gone down triglyceride, it has anti-inflammation action, and it may suppress cancer. We cannot synthesize it. It is a liquid state at 20℃ or 37℃. We will measure it quantitatively using mono-clonal antibody in vitro, but we measured unstable. We think it cannot keep balance of substance, or stabilizing of mono-clonal antibody. We will add antioxidants or change molecular weight or side chain of poly-unsaturated fatty acid.
If we are able to measure poly-unsaturated fatty acid, we will measure transfer rate to lymphoid tissue on the peritoneum at Intraperitoneal injection, and presuppose side effect on other organ.
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