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Detection of invisible metastatic lesion of digestive cancer using positron emission tomography and therapeutic strategy against hepatic metastasis

Research Project

Project/Area Number14571219
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TANIGUCHI Hiroki  Kyoto Prefectural University of Medicine, Faculty of Medicine, Instructor, 医学研究科, 講師 (20217136)

Project Period (FY) 2002 – 2004
Project Status Completed(Fiscal Year 2004)
Budget Amount *help
¥3,100,000 (Direct Cost : ¥3,100,000)
Fiscal Year 2004 : ¥1,000,000 (Direct Cost : ¥1,000,000)
Fiscal Year 2003 : ¥1,000,000 (Direct Cost : ¥1,000,000)
Fiscal Year 2002 : ¥1,100,000 (Direct Cost : ¥1,100,000)
KeywordsPisitron Emission Tomography / Digestive Cancer / metastasis / 転移性肝癌 / 腫瘍新生血管 / 微小肝転移 / 転移予知 / 血管新生
Research Abstract

Even if hepatic metastasis is too small to be detected existing diagnostic modalities, the ratio between arterial and portal blood flow in the liver should change, that is, arterial hepatic blood flow increase and portal hepatic blood flow decrease in the liver.. To know this phenomenon with positron emission tomography make the early detection of hepatic metastasis possible, and early treatment for liver metastasis can be started. However, if extra hepatc metastasis exist, treatment for the only liver is non sense.
On the other hand, it is clarified that small extra hepatic metastatic lesion can be detected with 18-fluorodeoxy glucose positron emission tomography. Therefore, simultaneous quantification of hepatic arterial and portal blood flow using 15-water and, systemic measurement of glucose metabolism using 18-fluorodeoxy glucose with positron emission tomography prove existence of invisible liver metastasis and absence of extra hepatic metastatic lesion. This method will improve the treatment performance for metastatic liver cancer.

Report

(4results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • 2002 Annual Research Report

Research Products

(50results)

All 2005 2004 2003 2002 Other

All Journal Article Publications

  • [Journal Article] Intestinal protrusion by parastomal abdominal rupture as a late complication following colostomy-A case report.2005

    • Author(s)
      N.Fuji, H.Taniguchi, H.Amaike, K.Oka, K.Inaba, K.Naito
    • Journal Title

      Japanese Journal of Gastroenterological Surgery 38(1)

      Pages : 117-120

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine-18-labeled fluoro-deoxyglucose (FDG-PET)2004

    • Author(s)
      T.Koh.H.Taniguchi, A.Yamaguchi, S.Kunishima, H.Yamagishi
    • Journal Title

      DIGITAL MEDICINE 5(3)

      Pages : 53-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 根治切除後6年経過して胃所属リンパ節への単独転移再発を認めた横行結腸癌の1例2004

    • Author(s)
      天池寿, 谷口弘毅, 藤信明, 岡克彦, 稲葉一樹, 内藤和世, 土橋康成
    • Journal Title

      日本消化器外科学会雑誌 37(2)

      Pages : 223-228

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Relationships between oxygen and glucose metabolism in human liver tumours : positron emission tomography using ^<15>O and ^<18>F-deoxyglucose.2004

    • Author(s)
      K.Fukuda, H.Taniguchi, T.Koh, S.Kunishima, H.Yamagishi
    • Journal Title

      Nuclear Medicine Communications 25(6)

      Pages : 577-583

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 胃癌治療に対する当院での腹腔鏡補助下胃切除術の現状2004

    • Author(s)
      天池寿, 谷口弘毅, 藤信明, 岡克彦, 稲葉一樹, 前田孝文, 内藤和世
    • Journal Title

      京都府立医科大学雑誌 113(8)

      Pages : 573-580

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 腹腔鏡補助下大腸切除の臨床病理学的検討2004

    • Author(s)
      藤信明, 谷口弘毅, 天池寿, 岡克彦, 稲葉一樹, 前田孝文, 内藤和世
    • Journal Title

      京都府立医科大学雑誌 113(8)

      Pages : 581-587

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] (臨床医から見たClinical PETの有用性)肝腫瘍におけるFDG-PETの有用性2004

    • Author(s)
      谷口弘毅, 福田賢一郎, 高利守, 國嶋憲, 山口明浩, 鈴木多佳子, 谷池圭子
    • Journal Title

      DIGITAL MEDICINE 5(3)

      Pages : 53-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 胃癌治療に対する当院での腹腔鏡補助下幽門側胃切除(LADG)の初期成績2004

    • Author(s)
      天池寿, 谷口弘毅, 藤信明, 岡克彦, 前田孝文, 内藤和世
    • Journal Title

      京都府立医科大学雑誌 113(12)

      Pages : 867-872

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 傍ストーマの腹壁破裂により腸管脱出をきたした人工肛門の1例2004

    • Author(s)
      藤信明, 谷口弘毅, 天池寿, 岡克彦, 稲葉一樹, 内藤和世
    • Journal Title

      日本消化器外科学会雑誌 38(1)

      Pages : 117-120

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A case report of recurrent transverse colon cancer, which was metastasized to the gastric regional lymph nodes 6 years later from right hemicolectomy.2004

    • Author(s)
      H.Amaike, H.Taniguchi, N.Fuji, K.Oka, K.Inaba, K.Naito, Y.Tsuchihashi
    • Journal Title

      Japanese Journal of Gastroenterological Surgery 37(2)

      Pages : 223-228

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] A case of gastrointestinal stromal tumor in the lesser omentum.2004

    • Author(s)
      K.Kitagawa, M.Shirasu, N.Kaneshiro, Y.Yoshioka, N.Kikuoka, H.Taniguchi, H.Okabe
    • Journal Title

      Japanese Journal of Gastroenterological Surgery 37(6)

      Pages : 710-715

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The present status of laparoscope assisted distal gastrectomy for gastric cancer treatment in the Kyoto Prefectural Yosanoumi Hospital.2004

    • Author(s)
      H.Amaike, H.Taniguchi, N.Fuji, K.Oka, K.Inaba, T.Maeda, K.Naito
    • Journal Title

      Journal of Kyoto Prefectural University of Medicine 113(8)

      Pages : 573-580

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinico-pathological study for laparoscope assisted resection of the colon and rectum.2004

    • Author(s)
      N.Fuji, H.Taniguchi, H.Amaike, K.Oka, K.Inaba, T.Maeda, K.Naito
    • Journal Title

      Journal of Kyoto Prefectural University of Medicine 113(8)

      Pages : 581-586

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Report of a case with renal cell carcinoma found by metastasis to ethmoidal sinus.2004

    • Author(s)
      H.Yamao, Y.Imaide, K.Shogaki, T.Yamamoto, H.Tenjin, Y.Hayashi, T.Kawabe, K.Oka, H.Taniguchi, Y.Tuchihashi
    • Journal Title

      Urological Surgery 17(10)

      Pages : 1123-1126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Report of a case with insulinoma.2004

    • Author(s)
      Y.Murayama, H.Taniguchi, K.Inaba, T.Koh, N.Fuji, H.Amaike, K.Naito
    • Journal Title

      Journal of Kyoto Prefectural University of Medicine 113(11)

      Pages : 797-801

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Usefulness of FDG-PET for hepatic tumor.2004

    • Author(s)
      H.Taniguchi, K.Fukuda, T.Koh, S.Kunishima, A.Yamaguchi., T.Suzuki, K.Taniike
    • Journal Title

      DIGITAL MEDICINE 5(3)

      Pages : 53-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Early result of laparoscope assisted distal gastrectomy in the Kyoto Prefectural Yosanoumi, Hospital.2004

    • Author(s)
      H.Amaike, H.Taniguchi, N.Fuji, K.Oka, T.Maeda, K.Naito
    • Journal Title

      Journal of Kyoto Prefectural University of Medicine 113(12)

      Pages : 867-872

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Relationships between oxygen and glucose metabolism in human liver tumours : positron emission tomography using ^<15>O and ^<18>F-deoxyglucose.2004

    • Author(s)
      K.Fukuda, H.Taniguchi, T.Koh, S.Kunishima, H.Yamagishi
    • Journal Title

      Nuclear Medicine Communications 25・6

      Pages : 577-583

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 腹腔鏡補助下大腸切除の臨床病理学的検討2004

    • Author(s)
      藤信明, 谷口弘毅, 天池寿, 岡克彦, 稲葉一樹, 前田孝文, 内藤和世
    • Journal Title

      京都府立医科大学雑誌 113・8

      Pages : 581-587

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 胃癌治療に対する当院での腹腔鏡補助下胃切除術の現状2004

    • Author(s)
      天池寿, 谷口弘毅, 藤信明, 岡克彦, 稲葉一樹, 前田孝文, 内藤和世
    • Journal Title

      京都府立医科大学雑誌 113・8

      Pages : 573-580

    • Related Report
      2004 Annual Research Report
  • [Journal Article] (臨床医から見たClinical PETの有用性)肝腫瘍におけるFDG-PETの有用性2004

    • Author(s)
      谷口弘毅, 福田賢一郎, 高利守, 國嶋憲, 山口明浩, 鈴木多佳子, 谷池圭子
    • Journal Title

      DIGITAL MEDICINE 5・3

      Pages : 53-55

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 胃癌治療に対する当院での腹腔鏡補助下幽門側胃切除(LADG)の初期成績2004

    • Author(s)
      天池寿, 谷口弘毅, 藤信明, 岡克彦, 前田孝文, 内藤和世
    • Journal Title

      京都府立医科大学雑誌 113・12

      Pages : 867-872

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 胆嚢摘出術後の胆汁瘻に対する経鼻胆道ドレナージ(ENBD)の有用性について2003

    • Author(s)
      北川一智, 谷口弘毅, 山岸久一
    • Journal Title

      京都府立医科大学雑誌 112(9)

      Pages : 673-678

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Changes in hepatic parenchymal blood flow with colorectal metastases : Increase in arterial and decrease in portal blood flow2003

    • Author(s)
      S.Kunishima, H.Taniguchi, A.Yamaguchi, T.Koh, H.Yamagishi
    • Journal Title

      Hepato-Gastroenterology 50(53)

      Pages : 1457-1462

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 出血を伴った憩室内ポリープによる成人腸重積の1例2003

    • Author(s)
      稲葉一樹, 谷口弘毅, 藤信明, 島田順一, 天池寿, 内藤和世
    • Journal Title

      日本臨床外科学会雑誌 64(11)

      Pages : 2779-2781

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The reproducibility of independently measuring human regional hepatic arterial, portal and total hepatic blood flow using [15O]water and positron emission tomography.2003

    • Author(s)
      H.Taniguchi, S.Kunishima, T.Koh
    • Journal Title

      Nuclear Medicine Communications 24(5)

      Pages : 497-501

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Usefulness of endoscopic naso-biliary drainage for biliary fistura after cholecystectomy.2003

    • Author(s)
      K.Kitagawa, H.Taniguchi, H.Yamagishi
    • Journal Title

      Journal of Kyoto Prefectural University of Medicine 112(9)

      Pages : 673-678

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Changes in hepatic parenchymal blood flow with colorectal metastases : Increase in arterial and decrease in portal blood flow.2003

    • Author(s)
      S.Kunishima, H.Taniguchi, A.Yamaguchi, T.Koh, H.Yamagishi
    • Journal Title

      Hepato-Gastroenterology 50(53)

      Pages : 1457-1462

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine-18-labeled fluoro-deoxyglucose (FDG-PET).2003

    • Author(s)
      T.Koh, H.Taniguchi, A.Yamaguchi, S.Kunishima, H.Yamagishi
    • Journal Title

      Journal of Surgical Oncology 84(2)

      Pages : 74-81

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Report of a adult case with intussusception due to a bleeding polyp in the diverticle.2003

    • Author(s)
      K.Inaba, H.Taniguchi, N.Fuji, J.Shimada, H.Amaike, K.Naito
    • Journal Title

      Journal of Japanese society of clinical surgery 64(11)

      Pages : 2779-2781

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] ポジトロンCTを用いた消化器癌肝転移の予知と早期診断法の開発に関する研究2002

    • Author(s)
      谷口弘毅
    • Journal Title

      INNERVISION 17(8)

      Pages : 50-50

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 残胃癌の臨床病理学的検討2002

    • Author(s)
      藤信明, 稲葉一樹, 天池寿, 島田順一, 谷口弘毅, 内藤和世
    • Journal Title

      京都府立医科大学雑誌 111(5)

      Pages : 377-381

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 膵浸潤した十二指腸癌に対し下部十二指腸および膵鉤部背側半切除を行った1例2002

    • Author(s)
      藤山准真, 萩原明於, 阪倉長平, 大辻英吾, 谷口弘毅, 山岸久一
    • Journal Title

      日本臨床外科学会雑誌 63(5)

      Pages : 1198-1202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative measurement of regional blood flow in hepatic focal nodular hyperplasia : Findings on positron emission tomography2002

    • Author(s)
      S.Kunishima, T.Koh, K.Fukuda, H.Taniguchi
    • Journal Title

      Molecular Imaging and Biology 4(3)

      Pages : 253-256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Oxygen-15 positron-emission tomography for predicting selective delivery of a chemotherapeutic agent to hepatic cancers during angiotensin II-induced hypertension.2002

    • Author(s)
      T.Koh, H.Taniguchi, H.Yamagishi
    • Journal Title

      Cancer Chemotherapy and Pharmacology 51(4)

      Pages : 349-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The reproducibility of independently measuring human regional hepatic arterial, portal and total hepatic blood flow using [15O]water and positron emission tomography2002

    • Author(s)
      H.Taniguchi, S.Kunishima, T.Koh
    • Journal Title

      Nuclear Medicine Communications 24(5)

      Pages : 497-501

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Are both PIVKA-II and alpha-fetoprotein necessary in follow-up management after hepatic resection for hepatocellular carcinoma?2002

    • Author(s)
      T.Koh, H.Taniguchi, H.Katoh, S.Kunishima, A.Yamaguchi, H.Yamagishi
    • Journal Title

      Hepato-Gastroenterology 49(48)

      Pages : 1615-1618

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Prediction and early diagnosis of metastatic liver cancer.2002

    • Author(s)
      H.Taniguchi
    • Journal Title

      INNERVISION 17(8)

      Pages : 50-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinico-pathological study for remnant gastric cancer.2002

    • Author(s)
      N.Fuji, K.Inaba, H.Amaike, J.Shimada, H.Taniguchi, K.Naito
    • Journal Title

      Journal of Kyoto Prefectural University of Medicine 111(5)

      Pages : 377-381

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Report of a case with duodenal cancer invading to the pancreas undergone the resection of the distal duodenum and the uncus of the dorsal pancreas.2002

    • Author(s)
      J.Fujiyama, A.Hagiwara, C.Sakakura, E.Otsuji H.Taniguchi, H.Yamagishi
    • Journal Title

      Journal of Japanese society of clinical surgery 63(5)

      Pages : 1198-1202

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative measurement of regional blood flow in hepatic focal nodular hyperplasia : Findings on positron emission tomography.2002

    • Author(s)
      S.Kunishima, T.Koh, K.Fukuda, H.Taniguchi
    • Journal Title

      Molecular Imaging and Biology 4(3)

      Pages : 253-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Are both PIVKA-II and alpha-fetoprotein necessary in follow-up management after hepatic resection for hepatocellular carcinoma?.2002

    • Author(s)
      T.Koh, H.Taniguchi, H.Kato, S.Kunishima, A.Yamaguchi, H.Yamagishi
    • Journal Title

      Hepato-Gastroenterology 49(48)

      Pages : 1615-1618

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] T.Koh, H.Taniguchi, H.Yamagishi: "Oxygen-15 positron-emission tomography for predicting selective delivery of a chemotherapeutic agent to hepatic cancers during angiotensin II-induced hypertension"Cancer Chemotherapy and Pharmacology. 15・4. 349-358 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] H.Taniguchi, S.Kunishima, T.Koh: "The reproducibility of independently measuring human regional hepatic arterial, portal and total hepatic blood flow using [15O]water and positron emission tomography"Nuclear Medicine Communications. 24・5. 497-501 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Koh, H.Taniguchi, H.Kato, S.Kunishima, A.Yamaguchi: "Are both PIVKA-II and alpha-fetoprotein necessary in follow-up management after hepatic resection for hepatocellular carcinoma?"Hepato-Gastroenterology. 49・48. 1615-1618 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 北川一智, 谷口弘毅, 山岸久一: "胆嚢摘出術後の胆汁痩に対する経鼻胆道ドレナージ(ENBD)の有用性について"京都府立医科大学雑誌. 112・9. 673-678 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] S.Kunishima, H.Taniguchi, A.Yamaguchi, T.Koh, H.Yamagishi: "Changes in hepatic parenchymal blood flow with colorectal metastases : Increase in arterial and decrease in portal blood flow"Hepato-Gastroenterology. 50・53. 1456-1462 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] T.Koh, H.Taniguchi, A.Yamaguchi, S.Kunishima, H.Yamagishi: "Differential diagnosis of gallbladder cancer using positron emission tomography with fluorine-18-labeled fluoro-deoxyglucose (FDG-PET)"Journal of Surgical Oncology. 84・2. 74-81 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 谷口弘毅: "ポジトロンCTを用いた消化器癌肝転移の予知と早期診断法の開発に関する研究"INNERVISION. 17(8). 50-50 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Kunishima, T.Koh, K.Fukuda, H.Taniguchi: "Quantitative measurement of regional blood flow in hepatic focal nodular hyperplasia : Findings on positron emission tomography"Molecular Imaging and Biology. 4(3). 253-256 (2002)

    • Related Report
      2002 Annual Research Report

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Published : 2002-04-01   Modified : 2016-04-21  

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