| Project/Area Number |
14571252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
SAKURADA Akira (2003) TOHOKU UNIVERSITY, HOSPITAL, RESEARCH ASSOCIATE, 医学部附属病院, 助手 (60360872)
遠藤 千顕 (2002) 東北大学, 医学部・附属病院, 助手 (80333813)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Satoshi TOHOKU UNIVERSITY, HOSPITAL, RECTURER, 医学部附属病院, 講師 (50344669)
HOSHIKAWA Yasushi TOHKU UNIVERSITY, HOSPITAL, RESEARCH ASSOCIATE, 医学部附属病院, 助手 (90333814)
SATO Masami TOHOKU UNIVERSITY, INSTITUTE OF DEVELOPMENT, AGING AND CANCER, ASSOCIATE PROFESSOR, 加齢医学研究所, 助教授 (30250830)
MATSUMURA Yuji TOHOKU UNIVERSITY, HOSPITAL, RESEARCH ASSOCIATE, 医学部附属病院, 助手 (80281997)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | LUNG CANCER / SENTINEL NODE / INFRARED CAMERA / NDOCYANINE GREEN / NAVIGATION SURGERY / INTRAPULUMONARY NODES |
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| Research Abstract |
WE TESTED THE FEASIBILITY OF NON-RI NAVIGATION SURGERY FOR LUNG CANCER. IN THE PRESENT SUTDY. WE USED INDOCYANINE GREEN (ICG) AS A TRACER. OBSERVATION WAS PERFORMED THROUGH INFRAED CAMERA (ENDOSCOPE) SYSTEM BECAUSE ICG SHOWS ABSOUPTION SPECTRUM IN INFARED BAND. AFTER THORACOTOMY, 25MG/5ML OF ICG WAS INJECTED INTO LUNG TISSUE SURROUNDING TUMOR DIRECTLY AND OBSERVATION WAS PERFORMED WITHOUT OPERATION PROSEDURE. IN SIX CASES REGISTERED. USUAL LOBECTOMY AND SYSTEMIC NODAL DISSECTION WAS PERFORMED. NO NODAL METASTASIS WAS FOUND AND NO ADVERSE EFFECT OF ICG ADMINISTRATION WAS OCCURRED. BY OBSERVING DESSECTED LYMPH NODES THROUGH INFRARE CAMERA, ICG STATINING WAS CLEARLY OBSERVED AT MULTI-STATION IN ALL OF SIX CASES. THAT SHOWS THE USEFULNESS OF ICG FOR A TRACER OF LUNG CANCER OPERATION.
HOWEVER, BY INTRAOPERATIVE OBSERVATION THROUGH INFRAED ENDOSCOPE, WE COULD DETECT HIRAL NODE STAINING ONLY IN ONE CASE. WE SUGGEST THAT THE PENETRATION POWER THROUGH CONNECTIVE TISSUE OR PLEURA IS STILL INSUFFICIENT. IN ADDITION. VARIATION OF LYMPHATIC FLOW BY INDIVISUALS MIGHT BE INVOLVED. NOW WE ARE INVESTIGATING THE LYMPH NODES OF HILUM AND MEDIASTINUM TO KNOW THE DIFFERENCE BETWEEN LUNG AND THE OTHER ORGANS, BETWEEN HILUM AND MEDIASTINUM, AND BY INDIVISUALS.
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